Patents by Inventor Susan Cumberledge

Susan Cumberledge has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of use of fragments of secreted frizzled related protein, sFRP
    Patent number: 8735355
    Abstract: The invention stems from the discovery that sFRP and fragments thereof can bind to members of the Wnt family of proteins and cause an increase in Wnt biological activity. Furthermore, fragments of sFRP that do not contain the CRD domain are shown to bind to Wnt proteins and modulate Wnt biological activity. Accordingly, the invention provides these sFRP fragments and variants of these fragments, as well as vectors and host cells containing nucleic acid sequences encoding the sFRP fragments and variants.
    Type: Grant
    Filed: March 21, 2012
    Date of Patent: May 27, 2014
    Assignees: The United States of America as represented by the Secretary of the Department of Health and Human Services, University of Massachusetts
    Inventors: Jeffrey S. Rubin, Susan Cumberledge, Frieda Reichsman, Aykut Uren
  • SECRETED FRIZZLED RELATED PROTEIN, SFRP, FRAGMENTS AND METHODS OF USE THEREOF
    Publication number: 20120202749
    Abstract: The invention stems from the discovery that sFRP and fragments thereof can bind to members of the Wnt family of proteins and cause an increase in Wnt biological activity. Furthermore, fragments of sFRP that do not contain the CRD domain are shown to bind to Wnt proteins and modulate Wnt biological activity. Accordingly, the invention provides these sFRP fragments and variants of these fragments, as well as vectors and host cells containing nucleic acid sequences encoding the sFRP fragments and variants.
    Type: Application
    Filed: March 21, 2012
    Publication date: August 9, 2012
    Inventors: Jeffrey S. Rubin, Susan Cumberledge, Frieda Reichsman, Aykut Uren
  • Fragments of secreted frizzled related protein
    Patent number: 8158603
    Abstract: The invention stems from the discovery that sFRP and fragments thereof can bind to members of the Wnt family of proteins and cause an increase in Wnt biological activity. Furthermore, fragments of sFRP that do not contain the CRD domain are shown to bind to Wnt proteins and modulate Wnt biological activity. Accordingly, the invention provides these sFRP fragments and variants of these fragments, as well as vectors and host cells containing nucleic acid sequences encoding the sFRP fragments and variants.
    Type: Grant
    Filed: February 18, 2011
    Date of Patent: April 17, 2012
    Assignees: The United States of America as represented by the Secretary of the Department of Health and Human Services, University of Massachusetts
    Inventors: Jeffrey S. Rubin, Aykut Üren, Susan Cumberledge, Frieda Reichsman
  • SECRETED FRIZZLED RELATED PROTEIN, SFRP, FRAGMENTS AND METHODS OF USE THEREOF
    Publication number: 20110177554
    Abstract: The invention stems from the discovery that sFRP and fragments thereof can bind to members of the Wnt family of proteins and cause an increase in Wnt biological activity. Furthermore, fragments of sFRP that do not contain the CRD domain are shown to bind to Wnt proteins and modulate Wnt biological activity. Accordingly, the invention provides these sFRP fragments and variants of these fragments, as well as vectors and host cells containing nucleic acid sequences encoding the sFRP fragments and variants.
    Type: Application
    Filed: February 18, 2011
    Publication date: July 21, 2011
    Applicants: The Gov. of the U.S.A. as represented by the Secretary of the Dept. of Health & Human Services, The University of Massachusetts
    Inventors: JEFFREY S. RUBIN, SUSAN CUMBERLEDGE, FRIEDA REICHSMAN, AYKUT UREN
  • Secreted frizzled related protein, sFRP, fragments and methods of use thereof
    Patent number: 7947651
    Abstract: The invention stems from the discovery that sFRP and fragments thereof can bind to members of the Wnt family of proteins and cause an increase in Wnt biological activity. Furthermore, fragments of sFRP that do not contain the CRD domain are shown to bind to Wnt proteins and modulate Wnt biological activity. Accordingly, the invention provides these sFRP fragments and variants of these fragments, as well as vectors and host cells containing nucleic acid sequences encoding the sFRP fragments and variants.
    Type: Grant
    Filed: May 15, 2007
    Date of Patent: May 24, 2011
    Assignees: The United States of America as represented by the Department of Health and Human Services, University of Massachusetts
    Inventors: Jeffrey S. Rubin, Susan Cumberledge, Frieda Reichsman, Aykut Uren
  • SECRETED FRIZZLED RELATED PROTEIN, sFRP, FRAGMENTS AND METHODS OF USE THEREOF
    Publication number: 20080207504
    Abstract: The invention stems from the discovery that sFRP and fragments thereof can bind to members of the Wnt family of proteins and cause an increase in Wnt biological activity. Furthermore, fragments of sFRP that do not contain the CRD domain are shown to bind to Wnt proteins and modulate Wnt biological activity. Accordingly, the invention provides these sFRP fragments and variants of these fragments, as well as vectors and host cells containing nucleic acid sequences encoding the sFRP fragments and variants.
    Type: Application
    Filed: May 15, 2007
    Publication date: August 28, 2008
    Inventors: Jeffrey S. Rubin, Susan Cumberledge, Frieda Reichsman, Aykut Uren
  • Secreted frizzled related protein fragments
    Patent number: 7223853
    Abstract: The invention stems from the discovery that sFRP and fragments thereof can bind to members of the Wnt family of proteins and cause an increase in Wnt biological activity. Furthermore, fragments of sFRP that do not contain the CRD domain are shown to bind to Wnt proteins and modulate Wnt biological activity. Accordingly, the invention provides these sFRP fragments and variants of these fragments, as well as vectors and host cells containing nucleic acid sequences encoding the sFRP fragments and variants.
    Type: Grant
    Filed: April 28, 2003
    Date of Patent: May 29, 2007
    Assignees: The United States of America as represented by the Secretary of the Department of Health and Human Services., The University of Massachusetts
    Inventors: Frieda Reichsman, Aykut Üren, Jeffrey S. Rubin, Susan Cumberledge
  • Secreted frizzled related protein,sFRP, fragments and methods of use thereof
    Publication number: 20030187223
    Abstract: The invention stems from the discovery that sFRP and fragments thereof can bind to members of the Wnt family of proteins and cause an increase in Wnt biological activity. Furthermore, fragments of sFRP that do not contain the CRD domain are shown to bind to Wnt proteins and modulate Wnt biological activity. Accordingly, the invention provides these sFRP fragments and variants of these fragments, as well as vectors and host cells containing nucleic acid sequences encoding the sFRP fragments and variants.
    Type: Application
    Filed: April 28, 2003
    Publication date: October 2, 2003
    Applicants: The Government of the United States of America as represented by the, Secretary of the Department of Health and Human Services, The University of Massachusetts
    Inventors: Frieda Reichsman, Aykut Uren, Jeffrey S. Rubin, Susan Cumberledge
  • Secreted frizzled related protein, sFRP, fragments and methods of use thereof
    Patent number: 6600018
    Abstract: The invention stems from the discovery that sFRP and fragments thereof can bind to members of the Wnt family of proteins and cause an increase in Wnt biological activity. Furthermore, fragments of sFRP that do not contain the CRD domain are shown to bind to Wnt proteins and modulate Wnt biological activity. Accordingly, the invention provides these sFRP fragments and variants of these fragments, as well as vectors and host cells containing nucleic acid sequences encoding the sFRP fragments and variants.
    Type: Grant
    Filed: April 10, 2000
    Date of Patent: July 29, 2003
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Jeffrey S. Rubin, Susan Cumberledge, Frieda Reichsman, Aykut Uren