Patents by Inventor Susan D. Holderman
Susan D. Holderman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7629445Abstract: The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods for treating intestinal motility disorders and improving gastrointestinal function with Zven1 and Zven2 polypeptides.Type: GrantFiled: October 12, 2006Date of Patent: December 8, 2009Assignee: ZymoGenetics, Inc.Inventors: Susan D. Holderman, Chung Chan
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Patent number: 7563438Abstract: The present invention relates to antibodies and fragments thereof, polynucleotide and polypeptide molecules for zFGF5 a novel member of the FGF family. The polypeptides, and polynucleotides encoding them, are proliferative for muscle cells, in particular cardiac cells and may be used for remodeling cardiac tissue and improving cardiac function. The present invention also includes antibodies to the zFGF5 polypeptides.Type: GrantFiled: May 22, 2007Date of Patent: July 21, 2009Assignee: ZymoGenetics, Inc.Inventors: Theresa A. Deisher, Darrell C. Conklin, Fenella C. Raymond, Thomas R. Bukowski, Susan D. Holderman, Paul O. Sheppard
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Publication number: 20080233114Abstract: The present invention relates to polynucleotide and polypeptide molecules for zFGF5 a novel member of the FGF family. The polypeptides, and polynucleotides encoding them, are proliferative for muscle cells, in particular cardiac cells and may be used for remodeling cardiac tissue and improving cardiac function. The present invention also includes antibodies to the zFGF5 polypeptides.Type: ApplicationFiled: May 22, 2007Publication date: September 25, 2008Inventors: Theresa A. Deisher, Darrell C. Conklin, Fenella C. Raymond, Thomas R. Bukowski, Susan D. Holderman, Paul O. Sheppard
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Patent number: 7250274Abstract: The expression vectors and methods using an E. coli expression system for the large scale production of IL-21 are described. The vectors utilize the IL-21 coding sequence with specific changes in nucleotides in order to optimize codons and mRNA secondary structure for translation in E. coli. Using the expression vectors, the IL-21 gene was produced in E. coli to a level of greater than 1 g/L in fed batch fermentation. Also included are OmpT deficient E. coli strains transformed with an IL-21 expression vector.Type: GrantFiled: December 12, 2003Date of Patent: July 31, 2007Assignee: ZymoGenetics, Inc.Inventors: Chung Chan, Bruce L. Zamost, Douglas C. Covert, Hong Y. Liu, Karen S. De Jongh, Jeffrey D. Meyer, Susan D. Holderman
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Patent number: 7247608Abstract: The present invention relates to polynucleotide and polypeptide molecules for zFGF-5 a novel member of the FGF family. The polypeptides, and polynucleotides encoding them, are proliferative for muscle cells and may be used for remodelling cardiac tissue and improving cardiac function. The present invention also includes antibodies to the zFGF-5 polypeptides.Type: GrantFiled: October 19, 2001Date of Patent: July 24, 2007Assignee: ZymoGenetics, Inc.Inventors: Theresa A. Deisher, Darrell C. Conklin, Fenella Raymond, Thomas R. Bukowski, Susan D. Holderman, Birgit Hansen, Paul O. Sheppard
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Publication number: 20040162238Abstract: The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods for treating intestinal motility disorders and improving gastrointestinal funciton with Zven1 and Zven2 polypeptides.Type: ApplicationFiled: October 7, 2003Publication date: August 19, 2004Inventors: Penny J. Thompson, Katherine E. Lewis, Stephen R. Jaspers, Richard M. Garcia, Robert R. West, Susan D. Holderman, Chung Chan, Paul O. Sheppard, Anitra Wolf
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Publication number: 20040096936Abstract: The present invention relates to polynucleotide and polypeptide molecules for zFGF-5 a novel member of the FGF family. The polypeptides, and polynucleotides encoding them, are proliferative for muscle cells and may be used for remodelling cardiac tissue and improving cardiac function. The present invention also includes antibodies to the zFGF-5 polypeptides.Type: ApplicationFiled: October 19, 2001Publication date: May 20, 2004Applicant: ZymoGenetics, Inc.Inventors: Theresa A. Deisher, Darrell C. Conklin, Fenella Raymond, Thomas R. Bukowski, Susan D. Holderman, Birgit Hansen, Paul O. Sheppard
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Publication number: 20030108995Abstract: Leucine-rich motifs appear in a large number of proteins that perform critical biological functions, such as cell adhesion and signal transduction. Zlrr1 is a new member of the human leucine-rich repeat superfamily.Type: ApplicationFiled: August 9, 2002Publication date: June 12, 2003Inventors: Christopher S. Piddington, Susan D. Holderman
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Patent number: 6518236Abstract: The present invention relates to polynucleotide and polypeptide molecules for zFGF5 a novel member of the FGF family. The polypeptides, and polynucleotides encoding them, are proliferative for muscle cells, in particular cardiac cells and may be used for remodeling cardiac tissue and improving cardiac function. The present invention also includes antibodies to the zFGF5 polypeptides.Type: GrantFiled: January 13, 1999Date of Patent: February 11, 2003Assignee: ZymoGenetics, Inc.Inventors: Theresa A. Deisher, Darrell C. Conklin, Fenella Raymond, Thomas R. Bukowski, Susan D. Holderman, Birgit Hansen, Paul O. Sheppard
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Publication number: 20030008351Abstract: The present invention relates to polynucleotide and polypeptide molecules for ZFGF5 a novel member of the FGF family. The polypeptides, and polynucleotides encoding them, are proliferative for muscle cells, in particular cardiac cells and may be used for remodeling cardiac tissue and improving cardiac function. The present invention also includes antibodies to the zFGF5 polypeptides.Type: ApplicationFiled: February 21, 2002Publication date: January 9, 2003Applicant: ZymoGenetics, Inc.Inventors: Theresa A. Deisher, Darrell C. Conklin, Fenella C. Raymond, Thomas R. Bukowski, Susan D. Holderman, Paul O. Sheppard
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Publication number: 20020151492Abstract: Tissue-specific markers can be used to enhance diagnosis, staging, and treatment of cancer, as well as to detect metastases of tumors derived from that tissue. The present invention provides a novel human gene, designated as “Zalpha16,” which is preferentially expressed in testicular tissue.Type: ApplicationFiled: October 25, 2001Publication date: October 17, 2002Applicant: ZymoGenetics, Inc.Inventors: Darrell C. Conklin, Andrew L. Feldhaus, Susan D. Holderman
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Patent number: 6352971Abstract: The present invention relates to polynucleotide and polypeptide molecules for zFGF-5 a novel member of the FGF family. The polypeptides, and polynucleotides encoding them, are proliferative for muscle cells and may be used for remodelling cardiac tissue and improving cardiac function. The present invention also includes antibodies to the zFGF-5 polypeptides.Type: GrantFiled: August 5, 1999Date of Patent: March 5, 2002Assignee: ZymoGenetics, Inc.Inventors: Theresa A. Deisher, Darrell C. Conklin, Fenella Raymond, Thomas R. Bukowski, Susan D. Holderman, Birgit Hansen, Paul O. Sheppard
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Patent number: 5989866Abstract: The present invention relates to polynucleotide and polypeptide molecules for zFGF-5 a novel member of the FGF family. The polypeptides, and polynucleotides encoding them, are proliferative for muscle cells and may be used for remodelling cardiac tissue and improving cardiac function. The present invention also includes antibodies to the zFGF-5 polypeptides.Type: GrantFiled: October 16, 1997Date of Patent: November 23, 1999Assignee: ZymoGenetics, Inc.Inventors: Theresa A. Deisher, Darrell C. Conklin, Fenella Raymond, Thomas R. Bukowski, Susan D. Holderman, Birgit Hansen, Paul O. Sheppard
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Patent number: 5854039Abstract: Methods for transforming Pichia methanolica, and DNA molecules useful in transformation of P. methanolica, are disclosed. P. methanolica cells are exposed, in the presence of DNA molecules, to a pulsed electric field having a field strength of from 2.5 to 4.5 kV/cm and a pulse duration of from 1 to 40 milliseconds, whereby the DNA molecules are introduced into the cells. The DNA molecules may comprise an expression unit that includes a transcription promoter of a P. methanolica gene operably linked to a segment encoding a polypeptide or protein of interest. The DNA molecules may also encode a selectable marker, such as a P. methanolica ADE2 gene. Cells transformed according to the invention may be used in production systems for the preparation of proteins of commercial importance.Type: GrantFiled: July 14, 1997Date of Patent: December 29, 1998Assignee: ZymoGenetics, Inc.Inventors: Christopher K. Raymond, Susan D. Holderman, Erica Vanaja