Patents by Inventor Susan Eagle
Susan Eagle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11950890Abstract: Devices, systems, and methods for monitoring patient hemodynamic status, systemic vascular resistance, reversal of cardiac and respiratory rates, and patient respiratory volume or effort are disclosed. A peripheral venous pressure is measured and used to detect levels, changes, or problems relating to patient blood volume. The peripheral venous pressure measurement is transformed from the time domain to the frequency domain for analysis. A heart rate frequency is identified, and harmonics of the heart rate frequency are detected and evaluated to determine, among other things, hypovolemia or hypervolemia, systemic vascular resistance, and of cardiac and respiratory rates, and patient respiratory volume or effort.Type: GrantFiled: May 20, 2021Date of Patent: April 9, 2024Assignees: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE SAInventors: Jonathan Handler, James Martucci, Kyle Hocking, Susan Eagle, Colleen Brophy, Richard Boyer, Franz Baudenbacher
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Publication number: 20210267470Abstract: Devices, systems, and methods for monitoring patient hemodynamic status, systemic vascular resistance, reversal of cardiac and respiratory rates, and patient respiratory volume or effort are disclosed. A peripheral venous pressure is measured and used to detect levels, changes, or problems relating to patient blood volume. The peripheral venous pressure measurement is transformed from the time domain to the frequency domain for analysis. A heart rate frequency is identified, and harmonics of the heart rate frequency are detected and evaluated to determine, among other things, hypovolemia or hypervolemia, systemic vascular resistance, and of cardiac and respiratory rates, and patient respiratory volume or effort.Type: ApplicationFiled: May 20, 2021Publication date: September 2, 2021Inventors: Jonathan Handler, James Martucci, Kyle Hocking, Susan Eagle, Colleen Brophy, Richard Boyer, Franz Baudenbacher
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Publication number: 20210267469Abstract: Devices, systems, and methods for monitoring patient hemodynamic status, systemic vascular resistance, reversal of cardiac and respiratory rates, and patient respiratory volume or effort are disclosed. A peripheral venous pressure is measured and used to detect levels, changes, or problems relating to patient blood volume. The peripheral venous pressure measurement is transformed from the time domain to the frequency domain for analysis. A heart rate frequency is identified, and harmonics of the heart rate frequency are detected and evaluated to determine, among other things, hypovolemia or hypervolemia, systemic vascular resistance, and of cardiac and respiratory rates, and patient respiratory volume or effort.Type: ApplicationFiled: May 20, 2021Publication date: September 2, 2021Inventors: Jonathan Handler, James Martucci, Kyle Hocking, Susan Eagle, Colleen Brophy, Richard Boyer, Franz Baudenbacher
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Patent number: 11039753Abstract: Devices, systems, and methods for monitoring patient hemodynamic status, systemic vascular resistance, reversal of cardiac and respiratory rates, and patient respiratory volume or effort are disclosed. A peripheral venous pressure is measured and used to detect levels, changes, or problems relating to patient blood volume. The peripheral venous pressure measurement is transformed from the time domain to the frequency domain for analysis. A heart rate frequency is identified, and harmonics of the heart rate frequency are detected and evaluated to determine, among other things, hypovolemia or hypervolemia, systemic vascular resistance, and of cardiac and respiratory rates, and patient respiratory volume or effort.Type: GrantFiled: December 15, 2017Date of Patent: June 22, 2021Assignees: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE SAInventors: Jonathan Handler, James Martucci, Kyle Hocking, Susan Eagle, Colleen Brophy, Richard Boyer, Franz Baudenbacher
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Patent number: 11039754Abstract: Devices, systems, and methods for monitoring patient hemodynamic status, systemic vascular resistance, reversal of cardiac and respiratory rates, and patient respiratory volume or effort are disclosed. A peripheral venous pressure is measured and used to detect levels, changes, or problems relating to patient blood volume. The peripheral venous pressure measurement is transformed from the time domain to the frequency domain for analysis. A heart rate frequency is identified, and harmonics of the heart rate frequency are detected and evaluated to determine, among other things, hypovolemia or hypervolemia, systemic vascular resistance, and of cardiac and respiratory rates, and patient respiratory volume or effort.Type: GrantFiled: August 22, 2018Date of Patent: June 22, 2021Assignees: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE SAInventors: Jonathan Handler, James Martucci, Kyle Hocking, Susan Eagle, Colleen Brophy, Richard Boyer, Franz Baudenbacher
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Publication number: 20200179601Abstract: One aspect of the present disclosure is a system for hemodynamic resuscitation. The system includes an intravenous access device having a pressure sensor element configured to detect a peripheral venous pressure value in response to an occlusion of a peripheral vein. The system also includes a controller device that is configured to receive a signal from the pressure sensor comprising the peripheral venous pressure value, to process the signal to determine a hemodynamic parameter based on the peripheral venous pressure value, and to generate a resuscitation score based on the hemodynamic parameter.Type: ApplicationFiled: November 15, 2019Publication date: June 11, 2020Inventors: Kevin Sexton, Susan Eagle, Kyle Hocking, Franz Baudenbacher, Colleen Brophy, Richard Boyer
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Publication number: 20190343408Abstract: Devices, systems, and methods for monitoring patient hemodynamic status, systemic vascular resistance, reversal of cardiac and respiratory rates, and patient respiratory volume or effort are disclosed. A peripheral venous pressure is measured and used to detect levels, changes, or problems relating to patient blood volume. The peripheral venous pressure measurement is transformed from the time domain to the frequency domain for analysis. A heart rate frequency is identified, and harmonics of the heart rate frequency are detected and evaluated to determine, among other things, hypovolemia or hypervolemia, systemic vascular resistance, and of cardiac and respiratory rates, and patient respiratory volume or effort.Type: ApplicationFiled: August 22, 2018Publication date: November 14, 2019Inventors: Jonathan Handler, James Martucci, Kyle Hocking, Susan Eagle, Colleen Brophy, Richard Boyer, Franz Baudenbacher
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Patent number: 10456046Abstract: Aspects of the invention relates to systems and methods for detecting volume status, volume overload, dehydration, hemorrhage and real time assessment of resuscitation, as well as organ failure including but not limited cardiac, renal, and hepatic dysfunction, of a living subject using non-invasive vascular analysis (NIVA). In one embodiment, a non-invasive device, which includes at least one sensor, is used to acquire vascular signals from the living subject in real time. The vascular signals are sent to a controller, which processes the vascular signals to determine at least one hemodynamic parameter, such as the volume status of the living subject. In certain embodiments, the vascular signals are processed by a spectral fast Fourier transform (FFT) analysis to obtain the peripheral vascular signal frequency spectrum, and the volume status of the living subject may be determined by comparing amplitudes of the peaks of the peripheral vascular signal frequency spectrum.Type: GrantFiled: November 13, 2015Date of Patent: October 29, 2019Assignee: Vanderbilt UniversityInventors: Susan Eagle, Colleen Brophy, Kyle Hocking, Franz Baudenbacher, Richard Boyer
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Publication number: 20190269861Abstract: A method of measuring peripheral venous pressure includes providing a tubing operably connected between a fluid source and a vein, a fluid controlling device for occluding the tubing and configured to have an on position and an off position, and at least one pressure sensor in fluid communication with the tubing, placed between the fluid controlling device and the vein; selectively passing fluid from the fluid source to the vein, through the tubing, by the fluid controlling device; measuring both a fluid pressure from the fluid source and a distal venous pressure from the vein by the at least one pressure sensor when the fluid controlling device is in the on position; and measuring the distal venous pressure from the vein only by the at least one pressure sensor when the fluid controlling device is in the off position.Type: ApplicationFiled: May 20, 2019Publication date: September 5, 2019Inventors: Susan Eagle, Kevin Sexton, Colleen Brophy, Kyle Mitchell Hocking
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Publication number: 20190183362Abstract: Devices, systems, and methods for filtering medical device noise artifacts from circulatory waveform signals are disclosed. A circulatory pressure is measured and transformed from the time domain to the frequency domain for analysis to determine patient status. To avoid artifacts of the pumping, the time-domain measurements are filtered to generate a filtered time-domain signal, by removing active pumping periods. The filtered time-domain signal is transformed into a frequency-domain signal, which is analyzed based upon peaks indicating respiratory rate, heart rate, or harmonics thereof. Peaks may be adjusted based on a ratio that considers removed signals. A metric of patient status is then determined from the peaks or corresponding frequencies. The patient status may be related to blood volume of the patient and may be used to control pump operation.Type: ApplicationFiled: December 14, 2018Publication date: June 20, 2019Inventors: Jonathan Handler, James Martucci, Kyle Hocking, Susan Eagle, Colleen Brophy, Richard Boyer, Franz Baudenbacher
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Patent number: 10293118Abstract: In one aspect, an apparatus for measuring peripheral venous pressure includes a tubing having two ends with one end connectable to a fluid source and the other end connectable to a vein, a fluid controlling device configured to have an on position and an off position, and at least one pressure sensor configured to measure fluid pressures therein. When the fluid controlling device is in the on position, fluid flow in the tubing is allowed to pass through the fluid controlling device, such that the at least one pressure sensor measures both a fluid pressure from the fluid source and a distal venous pressure from the vein. When the fluid controlling device is in the off position, no fluid flow in the tubing is allowed to pass through the fluid controlling device, such that the at least one pressure sensor measures the distal venous pressure from the vein only.Type: GrantFiled: July 13, 2012Date of Patent: May 21, 2019Assignee: VANDERBILT UNIVERSITYInventors: Susan Eagle, Kevin Sexton, Colleen Brophy, Kyle Mitchell Hocking
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Publication number: 20190000326Abstract: Devices, systems, and methods for filtering medical device noise artifacts from venous waveform signals are disclosed. A peripheral venous pressure (PVP) is measured and transformed from the time domain to the frequency domain for analysis to determine patient status. To avoid artifacts of the pumping, the time-domain PVP measurements are filtered to generate a filtered time-domain PVP signal by removing active pumping periods. The filtered time-domain PVP signal is transformed into a frequency-domain PVP signal, which is analyzed based upon peaks indicating respiratory rate, heart rate, or harmonics thereof. A metric of patient status is then determined from the peaks or corresponding frequencies. The patient status may be related to blood volume of the patient and may be used to control pump operation.Type: ApplicationFiled: June 29, 2018Publication date: January 3, 2019Inventors: Jonathan Handler, James Martucci, Kyle Hocking, Susan Eagle, Colleen Brophy, Richard Boyer, Franz Baudenbacher
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Publication number: 20180168467Abstract: Devices, systems, and methods for monitoring patient hemodynamic status, systemic vascular resistance, reversal of cardiac and respiratory rates, and patient respiratory volume or effort are disclosed. A peripheral venous pressure is measured and used to detect levels, changes, or problems relating to patient blood volume. The peripheral venous pressure measurement is transformed from the time domain to the frequency domain for analysis. A heart rate frequency is identified, and harmonics of the heart rate frequency are detected and evaluated to determine, among other things, hypovolemia or hypervolemia, systemic vascular resistance, and of cardiac and respiratory rates, and patient respiratory volume or effort.Type: ApplicationFiled: December 15, 2017Publication date: June 21, 2018Inventors: Jonathan Handler, James Martucci, Kyle Hocking, Susan Eagle, Colleen Brophy, Richard Boyer, Franz Baudenbacher
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Publication number: 20170332919Abstract: Aspects of the invention relates to systems and methods for detecting volume status, volume overload, dehydration, hemorrhage and real time assessment of resuscitation, as well as organ failure including but not limited cardiac, renal, and hepatic dysfunction, of a living subject using non-invasive vascular analysis (NIVA). In one embodiment, a non-invasive device, which includes at least one sensor, is used to acquire vascular signals from the living subject in real time. The vascular signals are sent to a controller, which processes the vascular signals to determine at least one hemodynamic parameter, such as the volume status of the living subject. In certain embodiments, the vascular signals are processed by a spectral fast Fourier transform (FFT) analysis to obtain the peripheral vascular signal frequency spectrum, and the volume status of the living subject may be determined by comparing amplitudes of the peaks of the peripheral vascular signal frequency spectrum.Type: ApplicationFiled: November 13, 2015Publication date: November 23, 2017Inventors: Susan Eagle, Colleen Brophy, Kyle Hocking, Franz Baudenbacher, Richard Boyer
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Publication number: 20160073959Abstract: Aspects of the invention relates to systems and methods for hypovolemia and/or hypervolemia detection of a living subject using peripheral intravenous waveform analysis. In one embodiment, the method includes: acquiring, from a vein of the living subject, peripheral venous signals; performing a spectral analysis on the acquired peripheral venous signals to obtain a peripheral venous pressure frequency spectrum; and performing a statistical analysis on amplitudes of peaks of the peripheral venous pressure frequency spectrum to determine the blood volume status of the living subject in real time. Specifically, at least two peaks, respectively corresponding to a first frequency and a second frequency, are obtained on the peripheral venous pressure frequency spectrum. Amplitude change of the second peak is used to determine the blood volume status of the living subject. Hemorrhage may be detected when a significant amplitude decrease is detected from the second baseline peak to the second peak.Type: ApplicationFiled: September 14, 2015Publication date: March 17, 2016Inventors: Susan Eagle, Colleen Brophy, Kyle Hocking, Franz Baudenbacher, Richard Boyer
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Publication number: 20150359489Abstract: One aspect of the present disclosure is a smart patient monitoring system. A sensor is coupled to a patient and configured to detect biometric data associated with the patient. A mobile computing device includes a memory that stores computer-executable instructions and a processor executes the computer-executable instructions. The mobile computing device receives the biometric data from the sensor; processes the biometric data to monitor a health status of the patient; and provides therapeutic feedback related to the health status.Type: ApplicationFiled: January 24, 2014Publication date: December 17, 2015Inventors: Franz Baudenbacher, Susan Eagle, Rene Harder, Jonathan Whitfield, Andre Diedrich, John B. Pietsch, Eric-Jan Manders
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Publication number: 20140207062Abstract: In one aspect, an apparatus for measuring peripheral venous pressure includes a tubing having two ends with one end connectable to a fluid source and the other end connectable to a vein, a fluid controlling device configured to have an on position and an off position, and at least one pressure sensor configured to measure fluid pressures therein. When the fluid controlling device is in the on position, fluid flow in the tubing is allowed to pass through the fluid controlling device, such that the at least one pressure sensor measures both a fluid pressure from the fluid source and a distal venous pressure from the vein. When the fluid controlling device is in the off position, no fluid flow in the tubing is allowed to pass through the fluid controlling device, such that the at least one pressure sensor measures the distal venous pressure from the vein only.Type: ApplicationFiled: July 13, 2012Publication date: July 24, 2014Applicant: VANDERBILT UNIVERSITYInventors: Susan Eagle, Kevin Sexton, Colleen Brophy, Kyle Mitchell Hocking
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Publication number: 20140073973Abstract: One aspect of the present disclosure is a system for hemodynamic resuscitation. The system includes an intravenous access device having a pressure sensor element configured to detect a peripheral venous pressure value in response to an occlusion of a peripheral vein. The system also includes a controller device that is configured to receive a signal from the pressure sensor comprising the peripheral venous pressure value, to process the signal to determine a hemodynamic parameter based on the peripheral venous pressure value, and to generate a resuscitation score based on the hemodynamic parameter.Type: ApplicationFiled: September 10, 2013Publication date: March 13, 2014Applicant: Vanderbilt UniversityInventors: Kevin Sexton, Susan Eagle, Kyle Hocking, Franz Baudenbacher, Colleen Brophy
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Publication number: 20020048802Abstract: The present invention relates to a prokaryotic reverse transcriptase enzyme. The enzyme is capable of synthesizing a hybrid DNA-RNA molecule called msDNA with the genes which synthesize the DNA and RNA portions of the molecule.Type: ApplicationFiled: March 3, 1997Publication date: April 25, 2002Inventors: SUMIKO INOUYE, MEI-YIN HSU, MASAYORI INOUYE, SUSAN EAGLE, BERT C. LAMPSON, JUNG SUN, JORGE VALLEJO-RAMIREZ
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Patent number: 5320958Abstract: The present invention relates to an isolated bacterial reverse transcriptase. The reverse transcriptase synthesizes a peculiar RNA-DNA complex called msDNA which is a single-stranded DNA structure branched out from an RNA molecule. The gene coding for the reverse transcriptase has been isolated and sequenced. It codes for a polypeptide of 485 amino acid residues. This is the first time that a reverse transcriptase has been found, identified and isolated from a prokaryotic microorganism of which the amino acid sequence is shown in FIGS. 2a-2d.Type: GrantFiled: February 24, 1989Date of Patent: June 14, 1994Assignee: University of Medicine and Dentistry of New JerseyInventors: Sumiko Inouye, Mei-Yin Hsu, Susan Eagle, Masayori Inouye