Patents by Inventor Susan Freier

Susan Freier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MODULATION OF STAT 6 EXPRESSION FOR THE TREATMENT OF AIRWAY HYPERRESPONSIVENESS
    Publication number: 20090191133
    Abstract: Disclosed herein are compounds, compositions and methods for modulating the expression of STAT 6 in a cell, tissue, or animal. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders related to expression of STAT 6, airway hyperresponsiveness, and/or pulmonary inflammation.
    Type: Application
    Filed: June 26, 2008
    Publication date: July 30, 2009
    Applicant: Isis Pharmaceuticals, Inc.
    Inventors: James KARRAS, Jeffrey CROSBY, Brett MONIA, Susan Freier
  • COMPOSITIONS AND THEIR USES DIRECTED TO HUNTINGTIN
    Publication number: 20080039418
    Abstract: Disclosed herein are compounds, compositions and methods for modulating the expression of huntingtin in a cell, tissue or animal. Further provided are methods of slowing or preventing Huntington's disease progression using an antisense compound targeted to huntingtin. Additionally provided are methods of delaying or preventing the onset of Huntingtin's disease in an individual susceptible to Huntingtin's Disease. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders.
    Type: Application
    Filed: January 26, 2007
    Publication date: February 14, 2008
    Inventor: Susan Freier
  • OLIGONUCLEOTIDE COMPOSITIONS AND METHODS FOR THE MODULATION OF THE EXPRESSION OF B7 PROTEIN
    Publication number: 20080027019
    Abstract: Compositions and methods for the treatment of asthma with oligonucleotides which specifically hybridize with nucleic acids encoding B7 proteins.
    Type: Application
    Filed: May 14, 2007
    Publication date: January 31, 2008
    Applicant: Isis Pharmaceuticals, Inc.
    Inventors: Timothy Vickers, C. Bennett, Susan Freier, James Karras
  • MODULATION OF STAT5 EXPRESSION
    Publication number: 20070293663
    Abstract: Compounds, compositions and methods are provided for modulating the expression of STAT5. The compositions comprise oligonucleotides, targeted to nucleic acid encoding STAT5. Methods of using these compounds for modulation of STAT5 expression and for diagnosis and treatment of diseases and conditions associated with expression of STAT5 are provided.
    Type: Application
    Filed: November 3, 2006
    Publication date: December 20, 2007
    Applicant: Isis Pharmaceuticals, Inc.
    Inventors: Susan Freier, James Karras
  • COMPOSITIONS AND METHODS FOR MODULATION OF MCL-1 EXPRESSION
    Publication number: 20070270368
    Abstract: Disclosed herein are compounds, compositions and methods for modulating the expression of Mcl-1 in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders.
    Type: Application
    Filed: March 16, 2007
    Publication date: November 22, 2007
    Inventor: Susan Freier
  • MODULATION OF GLUCAGON RECEPTOR EXPRESSION
    Publication number: 20070238688
    Abstract: Compounds, compositions and methods are provided for modulating the expression of glucagon receptor. The compositions comprise oligonucleotides, targeted to nucleic acid encoding glucagon receptor. Methods of using these compounds for modulation of glucagon receptor expression and for diagnosis and treatment of disease associated with expression of glucagon receptor are provided.
    Type: Application
    Filed: April 5, 2007
    Publication date: October 11, 2007
    Inventors: Sanjay Bhanot, Susan Freier, Kenneth Dobie, Robert McKay
  • MODULATION OF GLUCAGON RECEPTOR EXPRESSION
    Publication number: 20070238687
    Abstract: Compounds, compositions and methods are provided for modulating the expression of glucagon receptor. The compositions comprise oligonucleotides, targeted to nucleic acid encoding glucagon receptor. Methods of using these compounds for modulation of glucagon receptor expression and for diagnosis and treatment of disease associated with expression of glucagon receptor are provided.
    Type: Application
    Filed: April 5, 2007
    Publication date: October 11, 2007
    Inventors: Sanjay Bhanot, Susan Freier, Kenneth Dobie, Robert McKay
  • MODULATION OF GLUCAGON RECEPTOR EXPRESSION
    Publication number: 20070238689
    Abstract: Compounds, compositions and methods are provided for modulating the expression of glucagon receptor. The compositions comprise oligonucleotides, targeted to nucleic acid encoding glucagon receptor. Methods of using these compounds for modulation of glucagon receptor expression and for diagnosis and treatment of disease associated with expression of glucagon receptor are provided.
    Type: Application
    Filed: April 5, 2007
    Publication date: October 11, 2007
    Inventors: Sanjay Bhanot, Susan Freier, Kenneth Dobie, Robert McKay
  • MODULATION OF ACE2 EXPRESSION
    Publication number: 20070238681
    Abstract: Compounds, compositions and methods are provided for modulating the expression of ACE2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding ACE2. Methods of using these compounds for modulation of ACE2 expression and for diagnosis and treatment of diseases and conditions associated with expression of ACE2 are provided.
    Type: Application
    Filed: December 7, 2006
    Publication date: October 11, 2007
    Inventors: Kenneth Dobie, Susan Freier, Michael Buchmeier, Benjamin Neuman, C. Bennett, Namir Sioufi
  • Modulation of ace2 expression
    Publication number: 20070185044
    Abstract: Compounds, compositions and methods are provided for modulating the expression of ACE2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding ACE2. Methods of using these compounds for modulation of ACE2 expression and for diagnosis and treatment of diseases and conditions associated with expression of ACE2 are provided.
    Type: Application
    Filed: March 8, 2005
    Publication date: August 9, 2007
    Inventors: Kenneth Dobie, Susan Freier, Michael Buchmeier, Benjamin Neuman, C. Bennett, Namir Sioufi
  • COMPOSITIONS AND THEIR USES DIRECTED TO IL-4R ALPHA
    Publication number: 20070161593
    Abstract: Disclosed herein are compounds, compositions and methods for modulating the expression of IL-4R alpha in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders related to expression of IL 4R-?, airway hyperresponsiveness, and/or pulmonary inflammation.
    Type: Application
    Filed: October 11, 2006
    Publication date: July 12, 2007
    Applicant: Isis Pharmaceuticals, Inc.
    Inventors: James Karras, Susan Gregory, Susan Freier, William Gaarde, Mausumee Guha
  • COMPOSITIONS AND THEIR USES DIRECTED TO IL-4R ALPHA
    Publication number: 20070161594
    Abstract: Disclosed herein are compounds, compositions and methods for modulating the expression of IL-4R alpha in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders related to expression of IL 4R-?, airway hyperresponsiveness, and/or pulmonary inflammation.
    Type: Application
    Filed: October 11, 2006
    Publication date: July 12, 2007
    Applicant: Isis Pharmaceuticals, Inc.
    Inventors: James Karras, Susan Gregory, Susan Freier, Kenneth Dobie
  • Compositions and methods for the modulation of the expression of b7 protein
    Publication number: 20070135364
    Abstract: Anti sense oligonucleotide compositions which specifically hybridize with nucleic acids encoding B7 proteins, and use of these compositions for inhibiting expression of B7 mRNA.
    Type: Application
    Filed: May 19, 2004
    Publication date: June 14, 2007
    Inventors: C. Bennett, Timothy Vickers, James Karras, Susan Freier
  • Modulation of glucagon receptor expression
    Publication number: 20070087987
    Abstract: Compounds, compositions and methods are provided for modulating the expression of glucagon receptor. The compositions comprise antisense compounds, particularly antisense oligonucleotides which have particular in vivo properties, targeted to nucleic acids encoding glucagon receptor. Methods of using these compounds for modulation of glucagon receptor expression and for treatment of diseases are provided.
    Type: Application
    Filed: September 19, 2006
    Publication date: April 19, 2007
    Inventors: Brett Monia, Susan Freier, Sanjay Bhanot
  • Modulation of glucocorticoid receptor expression
    Publication number: 20070066557
    Abstract: Compounds, compositions and methods are provided for modulating the expression of glucocorticoid receptor. The compositions comprise antisense compounds, particularly antisense oligonucleotides which have particular in vivo properties, targeted to nucleic acids encoding glucocorticoid receptor. Methods of using these compounds for modulation of glucocorticoid receptor expression and for treatment of diseases are provided.
    Type: Application
    Filed: September 19, 2006
    Publication date: March 22, 2007
    Inventors: Brett Monia, Robert McKay, Susan Freier, Sanjay Bhanot, Lynnetta Watts
  • Modulation of elf4e expression
    Publication number: 20070066549
    Abstract: Oligomeric compounds, compositions and methods are provided for modulating the expression of eIF4E. The antisense compounds may be single- or double-stranded and are targeted to nucleic acid encoding eIF4E. Methods of using these compounds for modulation of eIF4E expression and for diagnosis and treatment of diseases and conditions associated with expression of eIF4E are provided.
    Type: Application
    Filed: September 17, 2004
    Publication date: March 22, 2007
    Inventors: Susan Freier, Kenneth Dobie, Eric Marcusson, Eric Swayze, Balkrishen Bhat, Jeremy Graff, Bruce Konicek
  • Modulation of HIF1alpha and HIF2alpha expression
    Publication number: 20070020679
    Abstract: Compounds, compositions and methods are provided for modulating the expression of HIF1? and/or HIF2?. The compositions comprise oligonucleotides, targeted to nucleic acid encoding HIF1? and HIF2?. Methods of using these compounds for modulation of HIF1? and/or HIF2? expression and for diagnosis and treatment of disease associated with expression of HIF1? and/or HIF2? are provided.
    Type: Application
    Filed: September 26, 2006
    Publication date: January 25, 2007
    Applicant: Isis Pharmaceuticals, Inc.
    Inventors: Donna Ward, Kenneth Dobie, Eric Marcusson, Susan Freier
  • Modulation of SOCS-3 expression
    Publication number: 20070021367
    Abstract: Compounds, compositions and methods are provided for modulating the expression of SOCS-3. The compositions comprise oligonucleotides, targeted to nucleic acid encoding SOCS-3. Methods of using these compounds for modulation of SOCS-3 expression and for diagnosis and treatment of disease associated with expression of SOCS-3 are provided.
    Type: Application
    Filed: August 17, 2006
    Publication date: January 25, 2007
    Inventors: Ian Popoff, Susan Freier, Kenneth Dobie
  • Modulation of STAT 6 expression for the treatment of airway hyperresponsiveness
    Publication number: 20060258610
    Abstract: Disclosed herein are compounds, compositions and methods for modulating the expression of STAT 6 in a cell, tissue, or animal. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders related to expression of STAT 6, airway hyperresponsiveness, and/or pulmonary inflammation.
    Type: Application
    Filed: May 11, 2006
    Publication date: November 16, 2006
    Applicant: Isis Pharmaceuticals, Inc.
    Inventors: James Karras, Jeffrey Crosby, Brett Monia, Susan Freier
  • Antisense modulation of CD40 ligand expression
    Publication number: 20060160758
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of CD40 ligand. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding CD40 ligand. Methods of using these compounds for modulation of CD40 ligand expression and for treatment of diseases associated with expression of CD40 ligand are provided.
    Type: Application
    Filed: January 20, 2005
    Publication date: July 20, 2006
    Inventors: C. Bennett, Susan Freier, Brenda Baker, Brett Monia, Nicholas Dean, Hong Zhang, Susan Murray, Lex Cowsert, Madeline Butler, Robert McKay, Donna Ward, William Gaarde, Ian Popoff, Jacqueline Wyatt, Andrew Watt