Patents by Inventor Susan G. Stuart
Susan G. Stuart has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7091020Abstract: The present invention provides a polynucleotide (hjak2) which identifies and encodes a novel human Jak2 kinase (HJAK2) which was expressed in the placenta. The present invention also provides for antisense molecules and oligomers designed from the nucleotide sequence or its antisense. The invention further provides genetically engineered expression vectors and host cells for the production of purified HJAK2 peptide, antibodies capable of binding to HJAK2, inhibitors which bind to HJAK2 and pharmaceutical compositions based on HJAK2 specific antibodies or inhibitors. The invention specifically provides for diagnostic assays based on altered hjak2 expression and which allow identification of such a condition. These assays utilize probes which comprise oligomers, fragments, or portions of hjak2 or its regulatory elements or antibodies specifically binding HJAK2.Type: GrantFiled: December 10, 1999Date of Patent: August 15, 2006Assignee: Incyte CorporationInventors: Roger Coleman, Susan G. Stuart
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Publication number: 20040077003Abstract: The present invention relates to a composition comprising a plurality of polynucleotide probes. The composition can be used as hybridizable array elements in a microarray. The present invention also relates to a method for selecting polynucleotide probes for the composition.Type: ApplicationFiled: August 14, 2003Publication date: April 22, 2004Applicant: Incyte CorporationInventors: Benjamin G. Cocks, Susan G. Stuart, Jeffrey J. Seilhamer
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Publication number: 20030180931Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode novel cellubrevins (cb). The present invention also provides for antisense molecules to the nucleotide sequences which encode cbs, expression vectors for the production of purified CBs, antibodies capable of binding specifically to CBs, hybridization probes or oligonucleotides for the detecting the induction of CB encoding nucleotide sequences, genetically engineered host cells for the expression of CBs, diagnostic tests for activated, inflamed or diseased cells and/or tissues based on CB-encoding nucleic acid molecules and antibodies capable of binding specifically to CBs.Type: ApplicationFiled: January 29, 2003Publication date: September 25, 2003Applicant: Incyte Genomics, Inc.Inventors: Susan G. Stuart, Phillip R. Hawkins, Jeffrey J. Seilhamer, Lynn E. Murry
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Publication number: 20030167480Abstract: The invention provides cDNA which encode Ndr2-related proteins. It also provides for the use of the cDNAs, fragments, complements, and variants thereof and of the encoded proteins, portions thereof and antibodies thereto for diagnosis and treatment of cancer, particularly cancers of the intestine, breast, uterus, liver, brain, and kidney. The invention additionally provides expression vectors and host cells for the production of the proteins and a transgenic model system.Type: ApplicationFiled: June 13, 2002Publication date: September 4, 2003Applicant: Incyte Genomics, Inc.Inventors: Susan G. Stuart, Janice Au-Young, Jennifer L. Hillman, Purvi Shah, Henry Yue
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Publication number: 20030166216Abstract: The invention provides a human checkpoint kinase (hChk1) and polynucleotides which identify and encode hChk1. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of hChk1.Type: ApplicationFiled: May 6, 2002Publication date: September 4, 2003Applicant: Incyte Genomics, Inc.Inventors: Stephen Green, Andrea Georgina King, Olga Bandman, Susan G. Stuart
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Patent number: 6607879Abstract: The present invention relates to a composition comprising a plurality of polynucleotide probes. The composition can be used as hybridizable array elements in a microarray. The present invention also relates to a method for selecting polynucleotide probes for the composition.Type: GrantFiled: February 9, 1998Date of Patent: August 19, 2003Assignee: Incyte CorporationInventors: Benjamin G. Cocks, Susan G. Stuart, Jeffrey J. Seilhamer
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Publication number: 20030138835Abstract: The invention provides a mammalian cDNA which encodes a mammalian MTSP. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of cancer, particularly breast cancer. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.Type: ApplicationFiled: January 21, 2003Publication date: July 24, 2003Applicant: Incyte Genomics, Inc.Inventors: Susan G. Stuart, Henry Yue, Mariah R. Baughn, David G. Streeter
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Publication number: 20030124543Abstract: The invention provides a cDNA which encodes a protein differentially expressed in breast cancer. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of cancer, particularly a breast cancer. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.Type: ApplicationFiled: February 20, 2002Publication date: July 3, 2003Inventors: Susan G. Stuart, David G. Streeter
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Publication number: 20030119009Abstract: The present invention relates to a combination comprising a plurality of cDNAs which are differentially expressed by MYCN activation and which may be used in their entirety or in part to diagnose, to stage, to treat, or to monitor the treatment of a subject with neuroblastoma.Type: ApplicationFiled: February 25, 2002Publication date: June 26, 2003Inventors: Susan G. Stuart, Jed G. Nuchtern, Sharon E. Plon, Jason M. Shohet
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Publication number: 20030109674Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode a novel purinergic PU2 receptor (PNR) expressed in human placenta. The present invention also provides for antisense molecules to the nucleotide sequences which encode PNR, expression vectors for the production of purified PNR, antibodies capable of binding specifically to PNR, hybridization probes or oligonucleotides for the detection of PNR-encoding nucleotide sequences, genetically engineered host cells for the expression of PNR, and diagnostic tests based on PNR-encoding nucleic acid molecules or antibodies produced against the polypeptide PNR.Type: ApplicationFiled: September 11, 2002Publication date: June 12, 2003Applicant: Incyte Genomics, Inc.Inventors: Roger Coleman, Janice Au-Young, Susan G. Stuart, Karl J. Guegler
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Patent number: 6534275Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode novel cellubrevins (cb). The present invention also provides for antisense molecules to the nucleotide sequences which encode cbs, expression vectors for the production of purified CBs, antibodies capable of binding specifically to CBs, hybridization probes or oligonucleotides for the detecting the induction of CB encoding nucleotide sequences, genetically engineered host cells for the expression of CBs, diagnostic tests for activated, inflamed or diseased cells and/or tissues based on CB-encoding nucleic acid molecules and antibodies capable of binding specifically to CBs.Type: GrantFiled: January 14, 2000Date of Patent: March 18, 2003Assignee: Incyte Genomics, Corp.Inventors: Susan G. Stuart, Phillip R. Hawkins, Jeffrey J. Seilhamer, Lynn E. Murry
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Publication number: 20030040615Abstract: The present invention provides purified polynucleotides, complements and fragments thereof, identified as encoding or regulating electron transfer molecules. The invention also provides for the use of these polynucleotides in methods to produce polypeptides and in the diagnosis, study, prevention, and treatment of disorders.Type: ApplicationFiled: March 24, 2000Publication date: February 27, 2003Inventors: Jeffrey J. Seilhamer, Angelo M. Delegeane, Susan G. Stuart, Laura L. Stuve, Sara J. Mullahy, Rebecca E. Naughton
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Patent number: 6479630Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode a novel purinergic PU2 receptor (PNR) expressed in human placenta. The present invention also provides for antisense molecules to the nucleotide sequences which encode PNR, expression vectors for the production of purified PNR, antibodies capable of binding specifically to PNR, hybridization probes or oligonucleotides for the detection of PNR-encoding nucleotide sequences, genetically engineered host cells for the expression of PNR, and diagnostic tests based on PNR-encoding nucleic acid molecules or antibodies produced against the polypeptide PNR.Type: GrantFiled: June 22, 1998Date of Patent: November 12, 2002Assignee: Incyte GenomicsInventors: Roger Coleman, Janice Au-Young, Susan G. Stuart, Karl J. Guegler
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Publication number: 20020155527Abstract: Disclosed are methods and compositions for identifying malignant tumors that overexpress the c-erbB-2 oncogene. Assays useful for diagnosis and prognosis of neoplastic disease are provided which detect the external domain of c-erbB-2, the glycoprotein gp75 and quantitate the level of gp75 in the biological fluids of mammals carrying a tumor burden.Type: ApplicationFiled: January 26, 2001Publication date: October 24, 2002Applicant: Triton BioSciences, Inc.Inventors: Susan G. Stuart, John J. Monahan, Beatrice Claudia Langton, Miriam E. C. Hancock, Lorrine A. Chao, Peter Bluford
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Publication number: 20020146767Abstract: The invention provides a cDNA which encodes a human Emr1-like G protein-coupled receptor. It also provides for the use of the cDNA, protein, and antibody in the diagnosis, prognosis, treatment and evaluation of therapies for respiratory, inflammatory, and immunological disorders. The invention further provides vectors and host cells for the production of the protein and transgenic model systems.Type: ApplicationFiled: November 13, 2001Publication date: October 10, 2002Inventors: Hong Xu, Victoria L. Cohan, Susan G. Stuart
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Patent number: 6444430Abstract: The invention provides cDNA which encode Ndr2-related proteins. It also provides for the use of the cDNAs, fragments, complements, and variants thereof and of the encoded proteins, portions thereof and antibodies thereto for diagnosis and treatment of cancer, particularly cancers of the intestine, breast, uterus, liver, brain, and kidney. The invention additionally provides expression vectors and host cells for the production of the proteins and a transgenic model system.Type: GrantFiled: March 19, 2001Date of Patent: September 3, 2002Assignee: Incyte Genomics, Inc.Inventors: Susan G. Stuart, Janice Au-Young, Jennifer L. Hillman, Purvi Shah, Henry Yue
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Patent number: 6383744Abstract: The invention provides a human checkpoint kinase (hChk1) and polynucleotides which identify and encode hChk1. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of hChk1.Type: GrantFiled: July 10, 1998Date of Patent: May 7, 2002Assignee: Incyte Genomics, Inc.Inventors: Stephen Green, Andrea Georgina King, Olga Bandman, Susan G. Stuart
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Patent number: 6368794Abstract: The present invention relates to polynucleotides comprising genes that regulate cell proliferation. The present invention also relates to a method for diagnosing or monitoring the treatment of a disease characterized by the altered expression of genes that regulate cell proliferation in a sample.Type: GrantFiled: January 15, 1999Date of Patent: April 9, 2002Assignee: Incyte Genomics, Inc.Inventors: Steven Daniel, James Gilmore, Susan G. Stuart, Laura L. Stuve
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Publication number: 20020039731Abstract: The invention provides cDNA which encode Ndr2-related proteins. It also provides for the use of the cDNAs, fragments, complements, and variants thereof and of the encoded proteins, portions thereof and antibodies thereto for diagnosis and treatment of cancer, particularly cancers of the intestine, breast, uterus, liver, brain, and kidney. The invention additionally provides expression vectors and host cells for the production of the proteins and a transgenic model system.Type: ApplicationFiled: March 19, 2001Publication date: April 4, 2002Inventors: Susan G. Stuart, Janice Au-Young, Jennifer L. Hillman, Purvi Shah, Henry Yue
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Patent number: 6060239Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode novel cellubrevins (cb). The present invention also provides for antisense molecules to the nucleotide sequences which encode cbs, expression vectors for the production of purified CBs, antibodies capable of binding specifically to CBs, hybridization probes or oligonucleotides for the detecting the induction of CB encoding nucleotide sequences, genetically engineered host cells for the expression of CBs, diagnostic tests for activated, inflamed or diseased cells and/or tissues based on CB-encoding nucleic acid molecules and antibodies capable of binding specifically to CBs.Type: GrantFiled: March 22, 1996Date of Patent: May 9, 2000Assignee: Incyte Pharmaceuticals, Inc.Inventors: Susan G. Stuart, Phillip R. Hawkins, Jeffrey J. Seilhamer, Lynn E. Murry