Patents by Inventor Susan Hagness

Susan Hagness has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210146127
    Abstract: A “localizable” systemic gene therapy system is provided substantially increasing the transfection efficiency of the gene vectors into targeted tissue cells and substantially reducing the escape of the gene vectors from the targeted tissue volume, such as would waste the vectors, promote undesired immune reactions, and/or incur prohibitive costs for the required dose of gene-containing virus vectors. In this regard, the invention provides a means to simultaneously achieve local electroporation and gene-containing vector injection in a portion of a vascularized organ. It includes two double-balloon catheters that create contained volumes in parallel blood vessels for the introduction of vectors with reduced loss along with electrodes providing electroporation of the cells in the same location where the vectors are injected.
    Type: Application
    Filed: January 28, 2021
    Publication date: May 20, 2021
    Inventors: Susan Hagness, Erik Aiken, John Booske, Hans Sollinger, Paul Laeseke, Tausif Alam
  • Patent number: 10918861
    Abstract: A “localizable” systemic gene therapy system is provided substantially increasing the transfection efficiency of the gene vectors into targeted tissue cells and substantially reducing the escape of the gene vectors from the targeted tissue volume, such as would waste the vectors, promote undesired immune reactions, and/or incur prohibitive costs for the required dose of gene-containing virus vectors. In this regard, the invention provides a means to simultaneously achieve local electroporation and gene-containing vector injection in a portion of a vascularized organ. It includes two double-balloon catheters that create contained volumes in parallel blood vessels for the introduction of vectors with reduced loss along with electrodes providing electroporation of the cells in the same location where the vectors are injected.
    Type: Grant
    Filed: July 24, 2018
    Date of Patent: February 16, 2021
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Susan Hagness, Erik Aiken, John Booske, Hans Sollinger, Paul Laeseke, Tausif Alam
  • Publication number: 20200030602
    Abstract: A “localizable” systemic gene therapy system is provided substantially increasing the transfection efficiency of the gene vectors into targeted tissue cells and substantially reducing the escape of the gene vectors from the targeted tissue volume, such as would waste the vectors, promote undesired immune reactions, and/or incur prohibitive costs for the required dose of gene-containing virus vectors. In this regard, the invention provides a means to simultaneously achieve local electroporation and gene-containing vector injection in a portion of a vascularized organ. It includes two double-balloon catheters that create contained volumes in parallel blood vessels for the introduction of vectors with reduced loss along with electrodes providing electroporation of the cells in the same location where the vectors are injected.
    Type: Application
    Filed: July 24, 2018
    Publication date: January 30, 2020
    Inventors: Susan Hagness, Erik Aiken, John Booske, Hans Sollinger, Paul Laeseke, Tausif Alam
  • Patent number: 9079011
    Abstract: A microwave hyperthermia treatment system employs a set of antennas individually controllable to provide different phase and amplitude outputs and controlled to cycle through different sets of phases and amplitudes over time to minimize the effect of hotspots formed by any given set of phases and amplitudes and creating limiting high temperatures outside of a desired treatment area.
    Type: Grant
    Filed: January 3, 2011
    Date of Patent: July 14, 2015
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Earl Zastrow, Susan Hagness, Barry Van Veen, Joshua Medow
  • Publication number: 20120172954
    Abstract: A microwave hyperthermia treatment system employs a set of antennas individually controllable to provide different phase and amplitude outputs and controlled to cycle through different sets of phases and amplitudes over time to minimize the effect of hotspots formed by any given set of phases and amplitudes and creating limiting high temperatures outside of a desired treatment area.
    Type: Application
    Filed: January 3, 2011
    Publication date: July 5, 2012
    Inventors: Earl Zastrow, Susan Hagness, Barry Van Veen, Joshua Medow
  • Patent number: 7482969
    Abstract: One embodiment of the present invention provides several electromagnetic radiation reflectors within a volume that contains solid portions subject to movement relative to one another. At least a portion of the reflectors are positioned beneath one or more of the solid portions and move in response to movement of at least some of the solid portions. The volume is irradiated with electromagnetic radiation having one or more frequencies in a range from one kHz through one THz, and a reflection is detected of at least a portion of the electromagnetic radiation from each of the reflectors in response to this irradiation. Movement among the solid objects is evaluated from the reflection of each of the reflectors, which includes determining a spatial orientation of each one of the reflectors as a function of at least one of polarization selectivity and frequency selectivity.
    Type: Grant
    Filed: June 14, 2006
    Date of Patent: January 27, 2009
    Assignee: Board of Trustees of the University of Illinois
    Inventors: Gregory Hilding Huff, Jennifer T. Bernhard, Susan Hagness, Debra Laefer
  • Publication number: 20070290917
    Abstract: One embodiment of the present invention provides several electromagnetic radiation reflectors within a volume that contains solid portions subject to movement relative to one another. At least a portion of the reflectors are positioned beneath one or more of the solid portions and move in response to movement of at least some of the solid portions. The volume is irradiated with electromagnetic radiation having one or more frequencies in a range from one kHz through one THz, and a reflection is detected of at least a portion of the electromagnetic radiation from each of the reflectors in response to this irradiation. Movement among the solid objects is evaluated from the reflection of each of the reflectors, which includes determining a spatial orientation of each one of the reflectors as a function of at least one of polarization selectivity and frequency selectivity.
    Type: Application
    Filed: June 14, 2006
    Publication date: December 20, 2007
    Inventors: Gregory Hilding Huff, Jennifer T. Bernhard, Susan Hagness, Debra Laefer
  • Publication number: 20060241409
    Abstract: A system and a method are provided for estimating the average dielectric properties of a plurality of regions in space. The application of this technique is illustrated for determining the average properties of breast tissue. The knowledge of average properties is important when UWB microwave radar signal processing algorithms are used for tumor detection and localization. The method is an extension of a time-domain inverse scattering algorithm based on the finite-difference time-domain method. A hybrid conjugate gradient optimization is used to minimize a cost function defined between a measured and a calculated total electromagnetic field at a series of antennas. The output of the method is an average set of electromagnetic material parameters that describe specific regions of interest in either a non-dispersive heterogeneous medium or a dispersive heterogeneous medium.
    Type: Application
    Filed: February 11, 2005
    Publication date: October 26, 2006
    Inventors: David Winters, Barry Van Veen, Susan Hagness
  • Publication number: 20060183995
    Abstract: A method and a system of determining a surface location defining an interface between an object to image and an antenna is provided. The method uses geometric principles and the fact that an impedance mismatch at the interface results in significant reflection. A propagation time from the surface to each antenna of a plurality of antennas is estimated. The propagation time locates the surface on a circle centered at each antenna and having a radius calculated using the propagation time. A tangent line connects the intersection of adjacent circles with the surface. The surface is estimated to be located at the tangent point where the circle and the shared tangent line between adjacent antennas intersect. Multiple tangent points may be averaged for each interior antenna. A curve is fit to the set of tangent points to provide an estimate of the surface location.
    Type: Application
    Filed: January 26, 2006
    Publication date: August 17, 2006
    Inventors: Essex Bond, Susan Hagness, Barry Veen
  • Publication number: 20060058606
    Abstract: Microwave examination of individuals is carried out by transmitting microwave signals from multiple antenna locations into an individual and receiving the backscattered microwave signals at multiple antenna locations to provide received signals from the antennas. The received signals are processed to remove the skin interface reflection component of the signal and the corrected signal data are provided to a hypothesis testing process. In hypothesis testing for detecting tumors, image data are formed from the test statistic used to perform a binary hypothesis test at each voxel. The null hypothesis asserts that no tumor is present at a candidate voxel location. The voxel threshold is determined by specifying a false discovery rate to control the expected proportion of false positives in the image. When the test statistic value associated with a voxel is greater than the threshold, the null hypothesis is rejected and the test statistic is assigned to the voxel.
    Type: Application
    Filed: September 15, 2004
    Publication date: March 16, 2006
    Inventors: Shakti Davis, Susan Hagness, Barry Van Veen
  • Patent number: 6421550
    Abstract: A non-invasive method to detect vascularization associated with one or more malignant tumors in living tissue of a living organism, where dielectric properties of the vascularization are different than dielectric properties of normal living tissue. In one embodiment, a non-ionizing input wave within a wide band frequency range is generated, and the input wave is applied to a field excitation antenna to illuminate a discrete volume within the living tissue of the living organism and to develop scattered power returns from the discrete volume. A receiving antenna then collects at least a portion of the scattered power returns. The scattered power returns are detected and then applied to a signal processor to develop a segregated signal, which is then processed in order to identify the vascularization associated with one or more malignant tumors.
    Type: Grant
    Filed: July 23, 1998
    Date of Patent: July 16, 2002
    Assignee: Interstitial, L.L.C.
    Inventors: Jack E. Bridges, Susan Hagness, Allen Taflove, Milica Popovic