Patents by Inventor Susan Jane Knox

Susan Jane Knox has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modulation of TIM receptor activity in combination with cytoreductive therapy
    Patent number: 9683049
    Abstract: A genetic locus and corresponding family of proteins associated with regulation of immune function and cell survival are provided. These genes encode cell surface molecules with conserved IgV and mucin domains. The locus comprising the TIM family is genetically associated with immune dysfunction, including asthma. Furthermore, the TIM gene family is located within a region of human chromosome 5 that is commonly deleted in malignancies and myelodysplastic syndrome. Polymorphisms in the gene sequences are associated with the development of airway hyperreactivity and allergic inflammation, and T cell production of IL-4 and IL-13. The proteins include the human hepatitis A cellular receptor, hHAVcr-1.
    Type: Grant
    Filed: April 10, 2014
    Date of Patent: June 20, 2017
    Assignees: The Board of Trustees of the Leland Stanford Junior University, Dana-Farber Cancer Institute, Inc., Children's Medical Center Corporation
    Inventors: Jennifer Jones, Rosemarie Dekruyff, Dale T. Umetsu, Gordon J. Freeman, Susan Jane Knox
  • Modulation of Tim Receptor Activity in Combination with Cytoreductive Therapy
    Publication number: 20150023986
    Abstract: A genetic locus and corresponding family of proteins associated with regulation of immune function and cell survival are provided. These genes encode cell surface molecules with conserved IgV and mucin domains. The locus comprising the TIM family is genetically associated with immune dysfunction, including asthma. Furthermore, the TIM gene family is located within a region of human chromosome 5 that is commonly deleted in malignancies and myelodysplastic syndrome. Polymorphisms in the gene sequences are associated with the development of airway hyperreactivity and allergic inflammation, and T cell production of IL-4 and IL-13. The proteins include the human hepatitis A cellular receptor, hHAVcr-1.
    Type: Application
    Filed: April 10, 2014
    Publication date: January 22, 2015
    Inventors: Jennifer Jones, Rosemarie Dekruyff, Dale T. Umetsu, Gordon J. Freeman, Susan Jane Knox
  • Modulation of TIM receptor activity in combination with cytoreductive therapy
    Patent number: 8709412
    Abstract: A genetic locus and corresponding family of proteins associated with regulation of immune function and cell survival are provided. These genes encode cell surface molecules with conserved IgV and mucin domains. The locus comprising the TIM family is genetically associated with immune dysfunction, including asthma. Furthermore, the TIM gene family is located within a region of human chromosome 5 that is commonly deleted in malignancies and myelodysplastic syndrome. Polymorphisms in the gene sequences are associated with the development of airway hyperreactivity and allergic inflammation, and T cell production of IL-4 and IL-13. The proteins include the human hepatitis A cellular receptor, hHAVcr-1.
    Type: Grant
    Filed: July 5, 2011
    Date of Patent: April 29, 2014
    Assignees: The Board of Trustees of the Leland Stanford Junior University, Dana-Farber Cancer Institute, Inc., Children's Hospital Corporation
    Inventors: Jennifer Jones, Rosemarie Dekruyff, Dale T. Umetsu, Gordon J. Freeman, Susan Jane Knox
  • MODULATION OF TIM RECEPTOR ACTIVITY IN COMBINATION WITH CYTOREDUCTIVE THERAPY
    Publication number: 20120156224
    Abstract: A genetic locus and corresponding family of proteins associated with regulation of immune function and cell survival are provided. These genes encode cell surface molecules with conserved IgV and mucin domains. The locus comprising the TIM family is genetically associated with immune dysfunction, including asthma. Furthermore, the TIM gene family is located within a region of human chromosome 5 that is commonly deleted in malignancies and myelodysplastic syndrome. Polymorphisms in the gene sequences are associated with the development of airway hyperreactivity and allergic inflammation, and T cell production of IL-4 and IL-13. The proteins include the human hepatitis A cellular receptor, hHAVcr-1.
    Type: Application
    Filed: July 5, 2011
    Publication date: June 21, 2012
    Inventors: Jennifer Jones, Rosemarie Dekruyff, Dale T. Umetsu, Gordon J. Freeman, Susan Jane Knox
  • Method of enhancing radiation resistance of normal cells
    Publication number: 20040110124
    Abstract: Methods are provided for increasing the resistance of normal cells to radiation damage, by administering an agent that induces hyperpolarization of the targeted cell membrane. Hyperpolarization may be induced prior to radiation exposure, or immediately afterwards, and preferably is continued for a period of time after exposure. Methods are also provided for means of screening candidate agents for use in radioprotection.
    Type: Application
    Filed: October 7, 2003
    Publication date: June 10, 2004
    Inventors: Susan Jane Knox, Shoucheng Ning