Patents by Inventor Susan L. Mooberry
Susan L. Mooberry has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10874631Abstract: Certain embodiments are directed to methods for treating Ewing family tumors (EFT) comprising administering an effective amount of altertoxin II to a subject having EFT.Type: GrantFiled: December 20, 2017Date of Patent: December 29, 2020Assignees: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM, THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMAInventors: Susan L Mooberry, Andrew J Robles, April L Risinger, Robert H Cichewicz, Saikat Haldar, Peter Houghton
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Publication number: 20200101038Abstract: Certain embodiments are directed to methods for treating Ewing family tumors (EFT) comprising administering an effective amount of altertoxin II to a subject having EFT.Type: ApplicationFiled: December 20, 2017Publication date: April 2, 2020Applicants: The Board of Regents of the University of Texas System, The Board of Regents of the University of Oklahoma SystemInventors: Susan L MOOBERRY, Andrew J ROBLES, April L RISINGER, Robert H CICHEWICZ, Salkat HALDAR, Peter HOUGHTON
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Publication number: 20200071351Abstract: This present disclosure relates to the fields of medicine and pharmaceuticals. In particular, the invention relates to the identification of epoxytaccalonolide microtubule stabilizers for use in inhibiting cell proliferation and disrupting normal cellular microtubule processes leading to cell death. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: ApplicationFiled: December 15, 2017Publication date: March 5, 2020Inventors: Susan L. Mooberry, April L. Risinger, Robert H. Cichewicz, Lin Du, Jing Li, Jiangnan Peng, Antonius Ola, Samantha S.M. Yee
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Patent number: 10501490Abstract: The invention provides epoxytaccalonolide microtubule stabilizers and their use as anti-proliferative microtubule stabilizing agents.Type: GrantFiled: July 18, 2017Date of Patent: December 10, 2019Assignee: The Board of Regents of the University of Texas SystemInventors: Susan L. Mooberry, Jiangnan Peng, April L. Risinger, Jing Li
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Patent number: 9944597Abstract: The present invention provides polysubstituted pyrrole compounds, pharmaceutically effective salts, prodrugs, solvates and hydrates thereof, having antimitotic, antiproliferative and cytotoxic activity, activity against cells expressing the drug efflux protein, P-glycoprotein, or cells expressing the ?-III isotype of tubulin and antitumor activity. Also provided are methods of utilizing these compounds for inhibiting the proliferation of cancer cells as well as their medical use, in particular for treating cancer, including drug resistant cancer.Type: GrantFiled: September 16, 2014Date of Patent: April 17, 2018Assignees: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM, VIRGINIA COMMONWEALTH UNIVERSITY, UNIVERSITY OF RICHMONDInventors: Glen E. Kellogg, Chenxiao Da, Ashutosh Tripathi, John T. Gupton, Nakul Telang, James A. Sikorski, Susan L. Mooberry, Cristina Rohena
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Publication number: 20170313739Abstract: The invention provides epoxytaccalonolide microtubule stabilizers and their use as anti-proliferative microtubule stabilizing agents.Type: ApplicationFiled: July 18, 2017Publication date: November 2, 2017Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEMInventors: Susan L. MOOBERRY, Jiangnan PENG, April L. RISINGER, Jing LI
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Publication number: 20160297757Abstract: The present invention provides polysubstituted pyrrole compounds, pharmaceutically effective salts, prodrugs, solvates and hydrates thereof, having antimitotic, antiproliferative and cytotoxic activity, activity against cells expressing the drug efflux protein, P-glycoprotein, or cells expressing the ?-III isotype of tubulin and antitumor activity. Also provided are methods of utilizing these compounds for inhibiting the proliferation of cancer cells as well as their medical use, in particular for treating cancer, including drug resistant cancer.Type: ApplicationFiled: September 16, 2014Publication date: October 13, 2016Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SY STEMInventors: Glen E. KELLOGG, Chenxiao DA, Ashutosh TRIPATHI, John T. GUPTON, Nankul TELANG, James A. SIKORSKI, Susan L. MOOBERRY, Cristina ROHENA
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Publication number: 20160257707Abstract: The invention provides epoxytaccalonolide microtubule stabilizers and their use as anti-proliferative microtubule stabilizing agents.Type: ApplicationFiled: May 12, 2016Publication date: September 8, 2016Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEMInventors: Susan L. MOOBERRY, Jiangnan PENG, April L. RISINGER, Jing LI
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Patent number: 9340572Abstract: The invention provides epoxytaccalonolide microtubule stabilizers and their use as anti-proliferative microtubule stabilizing agents.Type: GrantFiled: December 4, 2013Date of Patent: May 17, 2016Assignee: The Board of Regents of the University of Texas SystemInventors: Susan L. Mooberry, Jiangnan Peng, April L. Risinger, Jing Li
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Publication number: 20140357608Abstract: The invention provides epoxytaccalonolide microtubule stabilizers and their use as anti-proliferative microtubule stabilizing agents.Type: ApplicationFiled: December 4, 2013Publication date: December 4, 2014Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEMInventors: Susan L. MOOBERRY, Jiangnan PENG, April L. RISINGER, Jing LI
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Patent number: 7435754Abstract: A method of inhibiting the proliferation of a hyperproliferative mammalian cell having a multiple drug resistant phenotype utilizing an amount of a laulimalide compound effective to disrupt the dynamic state of microtubule polymerization and depolymerization to arrest cell mitosis is disclosed, together with laulimalide compounds which find use in such method.Type: GrantFiled: April 19, 2002Date of Patent: October 14, 2008Assignees: Utah State University, University of HawaiiInventors: Susan L. Mooberry, Bradley S. Davidson
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Patent number: 6878699Abstract: In accordance with the present invention, there have been identified extracts from a tropical plant that initiate paclitaxel-like microtubule bundling. Bioassay-directed purification yields the steroid taccalonolide A. Taccalonolide, like paclitaxel, initiates the formation of abnormal interphaes and mitotic microtubules. Cells treated with taccalonolide exhibit thick bundles of microtubules that appear to nucleate independent of the microtubule organizing center. Abnormal mitotic spindles consisting of multi-polar spindles are initiated by taccalonolide and resemble abnormal mitotic spindles found in the presence of paclitaxel. Like paclitaxel, taccalonolide causes the breakdown of the nucleus into micronuclei. Taccalonolide causes G2/M arrest, Bc1-2 phosphorylation and initiates an apoptotic cascade that includes the activation of caspase 3. Taccalonolide is an effective inhibitor of proliferation against both SK-OV-3 and MDA-MB-435 cell with IC50 values of 2.3 ?M and 2.1 ?M respectively.Type: GrantFiled: May 18, 2000Date of Patent: April 12, 2005Assignee: University of HawaiiInventors: Thomas K. Hemscheidt, Susan L. Mooberry
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Patent number: 6852710Abstract: The application discloses novel 2-alkoxyestradiol analogs which exhibit anti-proliferative properties, and methods of making and using such compounds to inhibit undesired cell proliferation and tumor growth. Additionally, methods are disclosed of treating diseases associated with undesired angiogenesis and undesired proliferation, and methods of treating infectious disease wherein the infectious agent is particularly susceptible to inhibition by agents that disrupt microtubule organization and function.Type: GrantFiled: April 11, 2003Date of Patent: February 8, 2005Assignee: Southwest Foundation for Biomedical ResearchInventors: Pemmaraju Narasimha Rao, Susan L. Mooberry, James W. Cessac, Tina L. Tinley
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Publication number: 20030229061Abstract: The application discloses novel 2-alkoxyestradiol analogs which exhibit anti-proliferative properties, and methods of making and using such compounds to inhibit undesired cell proliferation and tumor growth. Additionally, methods are disclosed of treating diseases associated with undesired angiogenesis and undesired proliferation, and methods of treating infectious disease wherein the infectious agent is particularly susceptible to inhibition by agents that disrupt microtubule organization and function.Type: ApplicationFiled: April 11, 2003Publication date: December 11, 2003Applicant: SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCHInventors: Pemmaraju Narasimha Rao, Susan L. Mooberry, James W. Cessac, Tina L. Tinley
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Patent number: 6593321Abstract: The application discloses novel 2-alkoxyestradiol analogs which exhibit anti-proliferative properties, and methods of making and using such compounds to inhibit undesired cell proliferation and tumor growth. Additionally, methods are disclosed of treating diseases associated with undesired angiogenesis and undesired proliferation, and methods of treating infectious disease wherein the infectious agent is particularly susceptible to inhibition by agents that disrupt microtubule organization and function.Type: GrantFiled: June 11, 2002Date of Patent: July 15, 2003Assignee: Southwest Foundation for Biomedical ResearchInventors: Pemmaraju Narasimha Rao, Susan L. Mooberry, James W. Cessac, Tina L. Tinley
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Publication number: 20030096799Abstract: The application discloses novel 2-alkoxyestradiol analogs which exhibit anti-proliferative properties, and methods of making and using such compounds to inhibit undesired cell proliferation and tumor growth. Additionally, methods are disclosed of treating diseases associated with undesired angiogenesis and undesired proliferation, and methods of treating infectious disease wherein the infectious agent is particularly susceptible to inhibition by agents that disrupt microtubule organization and function.Type: ApplicationFiled: June 11, 2002Publication date: May 22, 2003Inventors: Pemmaraju Narasimha Rao, Susan L. Mooberry, James W. Cessac, Tina L. Tinley
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Publication number: 20020198256Abstract: A method of inhibiting the proliferation of a hyperproliferative mammalian cell having a multiple drug resistant phenotype utilizing an amount of a laulimalide compound effective to disrupt the dynamic state of microtubule polymerization and depolymerization to arrest cell mitosis is disclosed, together with laulimalide compounds which find use in such method.Type: ApplicationFiled: April 19, 2002Publication date: December 26, 2002Applicant: Utah State UniversityInventors: Susan L. Mooberry, Bradley S. Davidson
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Patent number: 6414015Abstract: A method of inhibiting the proliferation of a hyperproliferative mammalian cell having a multiple drug resistant phenotype utilizing an amount of a laulimalide compound effective to disrupt the dynamic state of microtubule polymerization and depolymerization to arrest cell mitosis is disclosed, together with laulimalide compounds which find use in such method.Type: GrantFiled: January 28, 2000Date of Patent: July 2, 2002Assignees: Utah State University, University of HawaiiInventors: Susan L. Mooberry, Bradley S. Davidson
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Patent number: 5955423Abstract: A cryptophycin compound is provided having the structure: ##STR1## Further provided are methods for producing novel cryptophycins from the Nostoc sp. of blue-green algae (cyanobacteria). Pharmaceutical compositions comprising novel cryptophycins are also provided, as are methods for using cryptophycins to inhibit the proliferation of hyperproliferative cells. Further provided are methods for using cryptophycins to inhibit the proliferation of hyperproliferative cells with drug resistant phenotypes, and to treat pathological conditions, such as neoplasia.Type: GrantFiled: June 7, 1995Date of Patent: September 21, 1999Assignees: The University of Hawaii, Wayne State UniversityInventors: Richard E. Moore, Charles D. Smith, Gregory M. L. Patterson, Susan L. Mooberry, Thomas H. Corbett, Frederick A. Valeriote, Trimurtulu Golakoti
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Patent number: 5952298Abstract: A cryptophycin compound is provided having the structure: ##STR1## Further provided are methods for producing novel cryptophycins from the Nostoc sp. of blue-green algae (cyanobacteria). Pharmaceutical compositions comprising novel cryptophycins are also provided, as are methods for using cryptophycins to inhibit the proliferation of hyperproliferative cells. Further provided are methods for using cryptophycins to inhibit the proliferation of hyperproliferative cells with drug resistant phenotypes, and to treat pathological conditions, such as neoplasia.Type: GrantFiled: June 7, 1995Date of Patent: September 14, 1999Assignees: The University Of Hawaii, Wayne State UniversityInventors: Richard E. Moore, Charles D. Smith, Gregory M.L. Patterson, Susan L. Mooberry, Thomas H. Corbett, Frederick A. Valeriote, Trimurtulu Golakoti