Abstract: The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, U, W1, W2, W3, R1-R6, and R9 are described herein.

Abstract: Exemplary embodiments may provide a unified computing platform for multiple units of an organization that may interface with different clients, management and other stakeholders. The computing platform may include a unifying layer that provides personalization of access to computing resources across business areas and enables access to legacy computing resources. A unified experience is provided for the clients, management and stakeholders by the unifying layer. Common reusable code may be used across organizational units via the unifying layer. Exemplary embodiments may provide an onboarding software tool that improves onboarding of clients to a business organization, including interfacing with the unified computing platform. Exemplary embodiments may provide intelligent handling of trade or transaction exceptions in the unified computing platform across business lines.

Abstract: Disclosed herein are monoclonal antibodies and antigen-binding fragments thereof capable of selectively inhibiting TGF?1 with high potency. Related compositions, methods and therapeutic use are also disclosed.

Abstract: Disclosed herein are monoclonal antibodies and antigen-binding fragments thereof capable of selectively inhibiting TGF?1. Related compositions, methods and therapeutic use are also disclosed.

Abstract: Disclosed herein are monoclonal antibodies and antigen-binding fragments thereof capable of selectively inhibiting TGF?1 with high potency. Related compositions, methods and therapeutic use are also disclosed.

Abstract: Disclosed herein are monoclonal antibodies and antigen-binding fragments thereof capable of selectively inhibiting TGF?1 with high potency. Related compositions, methods and therapeutic use are also disclosed.

Abstract: A system for recommending comprises an interface and a processor. An interface is configured to receive an input. The input is stored and associated with two user identifiers. The processor is configured to make recommendations based at least in part on the input.

Abstract: Disclosed herein are monoclonal antibodies and antigen-binding fragments thereof capable of selectively inhibiting TGF?1 with high potency. Related compositions, methods and therapeutic use are also disclosed.

Abstract: A system for recommending comprises an interface and a processor. An interface is configured to receive an input. The input is stored and associated with two user identifiers. The processor is configured to make recommendations based at least in part on the input.

Abstract: In one embodiment, a display controller comprises control logic that rotates a frame image by two-dimensional blocks of pixels when the frame image is rotated from an original orientation.

Abstract: Effective enhancement of eyelash length and density can be obtained by topical applications of an active agent selected from a class of compounds consisting of synthetic prostaglandin agonists, polymers thereof and mixtures thereof preferably having the chemical formula of C24H35NO5, such as 7-[3.5-dihydroxy-2-(3-hydroxy-4phenoxy-but-1-enyl)-cyclopentyl]-hept-5-enoic acid ethylamide. Such active agents having a molecular weight of 417.54 can be employed in concentrations from 0.00075% to 0.03% by weight in mixtures with inactive ingredients, such as gels, oils, etc. Results are obtained by daily topical applications of active agent in such liquid mixtures (tinctures) at the roots of the lashes and/or lash follicles.

Abstract: The present invention uses a shielding metal on a motherboard of a mobile phone as a natural anti-radiation shield to design a monopole antenna hidden in the housing of the mobile phone to prevent the mobile phone from breakage, and to reduce radiation in the user direction from the monopole antenna. Moreover, the monopole antenna may be further connected to a helical coil antenna wherein the helical coil antenna is located in a direction perpendicular to the monopole antenna for enhancing the radiation effect and reducing the human injury by the radiation.

Abstract: This invention utilizes the anti-radiation metal cover of the mobile phone's motherboard as a natural radiation shield and designs many spiral and square flat sticker antennae, to be placed outside or inside mobile phone's plastic cover. The radiation from the antenna can only emit unidirectionally away from the user owing to the metal cover's shielding effect. Therefore, this type of antenna design is free of radiation damage to the phone users. The sticker antenna does not need to be wired to the mobile phones. It functions purely based on the electromagnetic induction between the phone's antenna and its motherboard. A small inductive bar, plugged in the hole where the original antenna was placed, will help the induction effect.

Abstract: This invention utilizes the anti-radiation metal cover of the mobile phone's motherboard as a natural radiation shield and designs many spiral and square flat sticker antennae, to be placed outside or inside mobile phone's plastic cover. The radiation from the antenna can only emit unidirectionally away from the user owing to the metal cover's shielding effect. Therefore, this type of antenna design is free of radiation damage to the phone users. The sticker antenna does not need to be wired to the mobile phones. It functions purely based on the electromagnetic induction between the phone's antenna and its motherboard. A small inductive bar, plugged in the hole where the original antenna was placed, will help the induction effect.