Patents by Inventor Susan M. Daluge

Susan M. Daluge has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Therapeutic nucleosides
    Patent number: 5637574
    Abstract: Compounds or formula (I), wherein R.sup.1 represents an n-propoxy, cyclobutoxy, cyclopropylamino, piperidino or pyrrolidino group; or a physiologically functional derivative thereof. The invention further includes methods for the preparation of compounds of formula (I), compositions containing them and the use of these compounds as antiviral agents.
    Type: Grant
    Filed: October 5, 1994
    Date of Patent: June 10, 1997
    Assignee: Glaxo Wellcome Inc.
    Inventors: Charlene L. Burns, George W. Koszalka, Thomas A. Krenitsky, Susan M. Daluge
  • Method of treating HIV infections with 2',3'-dideoxy-3'-fluoro-5-chlorouridine
    Patent number: 5574149
    Abstract: A method for treating HIV infections comprising administering a composition whose active ingredient is 2',3'-dideoxy-3'-fluoro-5'-chlorouridine.
    Type: Grant
    Filed: May 17, 1993
    Date of Patent: November 12, 1996
    Assignee: Glaxo Wellcome Inc.
    Inventors: Joel Van Tuttle, Susan M. Daluge, Charlene L. Burns, George W. Koszalka, Thomas A. Krenitsky
  • Therapeutic nucleosides
    Patent number: 5534535
    Abstract: Antiviral nucleoside analogues contain a substituted benzimidazole base attached to a carbocyclic ring in place of the conventional sugar residue. Particularly preferred compounds include those in which the 2-, 5- and 6- positions of the benzimidazole base are substituted by halogen. The compounds have activity against herpes virus especially cytomegalovirus and also hepatitis B virus infections.
    Type: Grant
    Filed: September 9, 1994
    Date of Patent: July 9, 1996
    Assignees: Burroughs Wellcome Co., The Regents of the University of Michigan
    Inventors: Leroy B. Townsend, John C. Drach, Steven S. Good, Susan M. Daluge, Michael T. Martin
  • Method for the treatment of protoza infections with 2.sup.1 -deoxy-2.sup.1 -fluoropurine nucleosides
    Patent number: 5420115
    Abstract: A method for treating two specific protozoal infections, Trichomonas vaginalis and Giardia lamblia, comprising the administration to a mammal in need thereof one of the following purine nucleosides:2,6-diamino-9-(2-deoxy-2-fluoro-.beta.-D-ribofuranosyl)-9H-purine2-amino-9-(2-deoxy-2-fluoro-.beta.-D-ribofuranosyl)-9H-purine2-amino-9-(2-deoxy-2-fluoro-.beta.-D-ribofuranosyl)-6-methoxy-9H-purine.
    Type: Grant
    Filed: September 2, 1992
    Date of Patent: May 30, 1995
    Assignee: Burroughs Wellcome Co.
    Inventors: Sylvia M. Tisdale, Joel Van Tuttle, Martin J. Slater, Susan M. Daluge, Wayne H. Miller, Thomas A. Krenitsky, George W. Koszalka
  • Therapeutic nucleosides-uses
    Patent number: 5399580
    Abstract: Antiviral nucleoside analogues containing a substituted benzimidazole base attached to a carbocyclic ring in place of the conventional sugar residue, particularly those in which the 2-, 5- and 6-positions of the benzimidazole base are substituted by halogen, have activity against hepatitis B virus infections.
    Type: Grant
    Filed: September 27, 1993
    Date of Patent: March 21, 1995
    Assignee: Burroughs Wellcome Co.
    Inventor: Susan M. Daluge
  • 4-amino-2-cyclopentene-1-methanol
    Patent number: 5206435
    Abstract: The present invention relates to 6-substituted purine carbocyclic nucleosides and their use in medical therapy particularly in the treatment of HIV and HBV infections. The invention also relates to pharmaceutical formulations and processes for the preparation of compounds according to the invention.
    Type: Grant
    Filed: September 27, 1991
    Date of Patent: April 27, 1993
    Assignee: Burroughs Wellcome Co.
    Inventor: Susan M. Daluge
  • Therapeutic nucleosides
    Patent number: 5089500
    Abstract: The present invention relates to 6-substituted purine carbocyclic nucleosides and their use in medical therapy particularly in the treatment of HIV and HBV infections. Also provided are pharmceutical formulations and processes for the preparation of compounds according to the invention.
    Type: Grant
    Filed: May 8, 1991
    Date of Patent: February 18, 1992
    Assignee: Burroughs Wellcome Co.
    Inventor: Susan M. Daluge
  • Therapeutic nucleosides
    Patent number: 5087697
    Abstract: The present invention relates to 6-substituted purine carbocyclic nucleosides and their use in medical therapy particularly in the treatment of HIV and HBV infections. The invention also relates to pharmaceutical formulations and processes for the preparation of compounds according to the invention.
    Type: Grant
    Filed: December 19, 1990
    Date of Patent: February 11, 1992
    Assignee: Burroughs Wellcome Co.
    Inventor: Susan M. Daluge
  • Antiviral compounds
    Patent number: 5070078
    Abstract: 2',3'-Dideoxy-3'-fluoro pyrimidine nucleosides particularly 2',3'-dideoxy-3'-fluorothymidine have been found to have particularly potent activity against adenovirus infections especially those caused by adenoviruses of serotype 8. Such compounds are preferably presented in pharmaceutical formulations adapted for ophthalmic administration.
    Type: Grant
    Filed: August 19, 1988
    Date of Patent: December 3, 1991
    Assignee: Burroughs Wellcome Co.
    Inventors: John W. T. Selway, Lowrie M. Beacham, III, Susan M. Daluge, Joel Van Tuttle, Thomas A. Krenitsky
  • 6-substituted purine carbocyclic nucleosides
    Patent number: 5049671
    Abstract: The present invention relates to 6-substituted purine carbocyclic nucleosides and their use in medical therapy particularly in the treatment of HIV and HBV infections. Also provided are pharmaceutical formulations and processes for the preparation of compounds according to the invention.
    Type: Grant
    Filed: December 22, 1989
    Date of Patent: September 17, 1991
    Assignee: Burroughs Wellcome Co.
    Inventor: Susan M. Daluge
  • Antiparasitic 3(4-amino benzotriazo-1-yl-)1,2-cyclopentanediols
    Patent number: 5039689
    Abstract: The present invention relates to the use of a compound of formula (I) ##STR1## wherein R representsa hydrogen atom; a C.sub.1-4 alkyl group;a group COR.sup.1 wherein R.sup.1 represents amino or C.sub.1-4 alkoxy; ora group --CH.sub.2 R.sup.2 wherein R.sup.2 represents a halogen atom (e.g. chlorine or bromine), C.sub.1-4 alkylthio, or azido,X and Y each independently represent --CH-- or --N; andZ represents --CR.sup.3, wherein R.sup.3 is hydrogen or C.sub.1-4 alkyl, or Z represents --N--;or a physiologically acceptable salt, ester or other physiologically functional derivative thereof,for the manufacture of a medicament for the treatment and/or prophylaxis of a parasitic infection in a mammal, and to certain novel compounds of formula (I), pharmaceutical compositions containing them and processes for their preparation.
    Type: Grant
    Filed: November 8, 1989
    Date of Patent: August 13, 1991
    Assignee: Burroughs Wellcome Co.
    Inventor: Susan M. Daluge
  • Therapeutic nucleosides
    Patent number: 5034394
    Abstract: The present invention relates to 6-substituted purine carbocyclic nucleosides and their use in medical therapy particularly in the treatment of HIV and HBV infections. Also provided are pharmaceutical formulations and processes for the preparation of compounds according to the invention.
    Type: Grant
    Filed: December 22, 1989
    Date of Patent: July 23, 1991
    Assignee: Burroughs Wellcome Co.
    Inventor: Susan M. Daluge
  • Methods for treating viral infection
    Patent number: 5017577
    Abstract: The present invention relates to certain novel 8-phenylxanthines substituted in the 3 or 4 position of the phenyl group by an alkenylene, alkenyleneoxy, alkynylene or alkynyleneoxy bearing a terminal acidic grouping, and to their use in human and veterinary therapy, particularly for conditions associated with the cell surface effects of adenosine and in antiviral, especially antiretroviral, chemotherapy.
    Type: Grant
    Filed: July 19, 1989
    Date of Patent: May 21, 1991
    Assignee: Burroughs Wellcome Co.
    Inventors: Susan M. Daluge, Harry J. Leighton, Sandra N. Lehrman
  • Method for treating viral infections
    Patent number: 5015647
    Abstract: The present invention relates to certain novel 8-phenylxanthines substituted in the 3 or 4 position of the phenyl group by an alkenylene, alkenyleneoxy, alkynylene or alkynyleneoxy bearing a terminal acidic grouping, and to their use in human and veterinary therapy, particularly for conditions associated with the cell surface effects of adenosine and in antiviral, especially antiretroviral, chemotherapy.
    Type: Grant
    Filed: July 19, 1989
    Date of Patent: May 14, 1991
    Assignee: Burroughs Wellcome Co.
    Inventors: Susan M. Daluge, Harry J. Leighton, Sandra N. Lehrman
  • Purine Derivatives
    Patent number: 4981857
    Abstract: The present invention relates to certain novel 8-phenylxanthines substituted in the 3 or 4 position of the phenyl group by an alkenylene, alkenyleneoxy, alkynylene or alkynyleneoxy bearing a terminal acidic grouping, and to their use in human and veterinary therapy, particularly for conditions associated with the cell surface effects of adenosine.
    Type: Grant
    Filed: August 29, 1989
    Date of Patent: January 1, 1991
    Assignee: Burroughs Wellcome Co.
    Inventors: Susan M. Daluge, Harry J. Leighton
  • Xanthine derivatives
    Patent number: 4879296
    Abstract: The present invention relates to certain novel 8-phenylxanthines substituted in the 3 or 4 position of the phenyl group by an alkenylene, alkenyleneoxy, alkynylene or alkynyleneoxy bearing a terminal acidic grouping, and to their use in human and veterinary therapy, particularly for conditions associated with the cell surface effects of adenosine.
    Type: Grant
    Filed: April 25, 1986
    Date of Patent: November 7, 1989
    Assignee: Burroughs Wellcome co.
    Inventors: Susan M. Daluge, Harry J. Leighton
  • 2,4-diaminopyrimidines substituted with heterobicyclomethyl radicals at the 5 position useful as antibacterials
    Patent number: 4761475
    Abstract: Novel 2,4-diaminopyrimidines having substituted heterobicyclomethyl moieties in the 5-position have superior antibacterial properties.
    Type: Grant
    Filed: March 12, 1986
    Date of Patent: August 2, 1988
    Inventors: Susan M. Daluge, Paul M. Skonezny
  • Monoheteroring compounds and their use
    Patent number: 4603136
    Abstract: Novel 2,4-diamino-5-(substituted naphthylmethyl)pyrimidines have been found to have superior antibacterial activity.
    Type: Grant
    Filed: December 30, 1983
    Date of Patent: July 29, 1986
    Inventors: Susan M. Daluge, Paul M. Skonezny
  • 2,4-diamino-5-(substituted)pyrimidines, useful as antimicrobials
    Patent number: 4590271
    Abstract: Compounds of the formula (II) ##STR1## or a salt, N-oxide or acyl derivative thereof, wherein Y is a group ##STR2## which is linked to the pyrimidinylmethyl moiety at the 1 or 7-position and is optionally substituted at the 2, 3, 4 or 6-position or at the 7-position when the linkage to the pyrimidinylmethyl moiety is at the 1-position wherein X is an oxygen or sulphur atom, a group CH.sub.2, a group S(O).sub.n where n=1 or 2, a group NR.sup.1 wherein R.sup.1 is hydrogen C.sub.1-4 alkyl or a group COR.sup.2 where R.sup.2 is hydrogen, C.sub.1-4 alkoxy or amino and the dotted line represents a single or double bond, have antimicrobial activity. Processes for making these compounds, pharmaceutical compositions containing them and the medical use of the compounds are also disclosed.
    Type: Grant
    Filed: April 29, 1983
    Date of Patent: May 20, 1986
    Assignee: Burroughs Wellcome Co.
    Inventors: Susan M. Daluge, Paul M. Skonezny, Barbara Roth, Barbara S. Rauckman
  • 2,4-diamino-(substituted-benzopyran(quinolyl,isoquinoly)methyl)pyrimidine s useful as antibacterials
    Patent number: 4587342
    Abstract: Novel 2,4-diaminopyrimidines having substituted heterobicyclomethyl moieties in the 5-position have superior antibacterial properties.
    Type: Grant
    Filed: October 31, 1983
    Date of Patent: May 6, 1986
    Inventors: Susan M. Daluge, Paul M. Skonezny