Patents by Inventor Susan M. Faust

Susan M. Faust has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CONSTRUCTS AND METHODS FOR DELIVERING MOLECULES VIA VIRAL VECTORS WITH BLUNTED INNATE IMMUNE RESPONSES
    Publication number: 20220154208
    Abstract: A CpG-modified recombinant adeno-associated viral (AAV) vector is described. The vector carries a nucleic acid molecule comprising AAV inverted terminal repeat (ITR) sequences and an exogenous gene sequence under the control of regulatory sequences which control expression of the gene product, in which the nucleic acid sequences carried by the vector are modified to significantly reduce CpG di-nucleotides such that an immune response to the vector is reduced as compared to the unmodified AAV vector. Also provided are methods and regimens for delivering transgenes using these AAV viral vectors, in which the innate immune response to the vector and/or transgene is significantly modulated.
    Type: Application
    Filed: May 11, 2021
    Publication date: May 19, 2022
    Inventors: Susan M. Faust, Joseph E. Rabinowitz, James M. Wilson
  • Constructs and methods for delivering molecules via viral vectors with blunted innate immune responses
    Patent number: 11015210
    Abstract: A CpG-modified recombinant adeno-associated viral (AAV) vector is described. The vector carries a nucleic acid molecule comprising AAV inverted terminal repeat (ITR) sequences and an exogenous gene sequence under the control of regulatory sequences which control expression of the gene product, in which the nucleic acid sequences carried by the vector are modified to significantly reduce CpG di-nucleotides such that an immune response to the vector is reduced as compared to the unmodified AAV vector. Also provided are methods and regimens for delivering transgenes using these AAV viral vectors, in which the innate immune response to the vector and/or transgene is significantly modulated.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: May 25, 2021
    Inventors: Susan M. Faust, Joseph E. Rabinowitz, James M. Wilson
  • CONSTRUCTS AND METHODS FOR DELIVERING MOLECULES VIA VIRAL VECTORS WITH BLUNTED INNATE IMMUNE RESPONSES
    Publication number: 20160222414
    Abstract: A CpG-modified recombinant adeno-associated viral (AAV) vector is described. The vector carries a nucleic acid molecule comprising AAV inverted terminal repeat (ITR) sequences and an exogenous gene sequence under the control of regulatory sequences which control expression of the gene product, in which the nucleic acid sequences carried by the vector are modified to significantly reduce CpG di-nucleotides such that an immune response to the vector is reduced as compared to the unmodified AAV vector. Also provided are methods and regimens for delivering transgenes using these AAV viral vectors, in which the innate immune response to the vector and/or transgene is significantly modulated.
    Type: Application
    Filed: April 15, 2016
    Publication date: August 4, 2016
    Inventors: Joseph E. Rabinowitz, James M. Wilson, Susan M. Faust
  • Constructs and Methods for Delivering Molecules via Viral Vectors with Blunted Innate Immune Responses
    Publication number: 20140271550
    Abstract: A CpG-modified recombinant adeno-associated viral (AAV) vector is described. The vector carries a nucleic acid molecule comprising AAV inverted terminal repeat (ITR) sequences and an exogenous gene sequence under the control of regulatory sequences which control expression of the gene product, in which the nucleic acid sequences carried by the vector are modified to significantly reduce CpG di-nucleotides such that an immune response to the vector is reduced as compared to the unmodified AAV vector. Also provided are methods and regimens for delivering transgenes using these AAV viral vectors, in which the innate immune response to the vector and/or transgene is significantly modulated.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Applicants: The Trustees of the University of Pennsylvania, Thomas Jefferson University
    Inventors: Joseph E. Rabinowitz, James M. Wilson, Susan M. Faust