Patents by Inventor Susan M. Gamble

Susan M. Gamble has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmacologic, therapeutic and diagnostic regulation of FGF-1 export
    Publication number: 20040071787
    Abstract: This invention relates to the regulation of FGF-1 export by cells. In addition, this invention provides methods of regulating the export of FGF-1 from the cell membrane, which methods include regulating the Syn-1 molecule to affect the formation of the FGF-Syn-1 complex, regulating the enzyme or protease which cleaves Syn-1 in the FGF-1 :Syn-1 complex to effect the release of FGF-1 from the cell membrane, or regulating the FGF-1:Syn-1 complex itself at or near the cell membrane. S100A13 is identified as an additional component of the FGF-1 export complex. Syn-1 truncation deletion mutants are also provided and functionally characterized. The invention also provides compositions related to the regulation of FGF-1 export.
    Type: Application
    Filed: March 6, 2003
    Publication date: April 15, 2004
    Applicant: Maine Medical Center Research Institute
    Inventors: Thomas Maciag, Brian Hampton, Wilson H. Burgess, Susan M. Gamble, Francesca Tarantini, Anthony Q. Jackson