Patents by Inventor Susan Marie Hennessey
Susan Marie Hennessey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11952598Abstract: Disclosed herein are glucosyltransferases with modified amino acid sequences. Such engineered enzymes exhibit improved alpha-glucan product yields and/or lower leucrose yields, for example. Further disclosed are reactions and methods in which engineered glucosyltransferases are used to produce alpha-glucan.Type: GrantFiled: June 4, 2021Date of Patent: April 9, 2024Assignee: NUTRITION & BIOSCIENCES USA 4, INC.Inventors: Yougen Li, Mark S. Payne, Jared B. Parker, Slavko Kralj, Veli Alkan, Richard R. Bott, Robert Dicosimo, Qiong Cheng, Ellen D. Semke, Susan Marie Hennessey
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Patent number: 11685907Abstract: A method for producing insoluble alpha-1,3-glucan is disclosed. Embodiments of the method comprise providing (i) oligosaccharides that comprise alpha-1,3 and alpha-1,6 glycosidic linkages, or (ii) oligosaccharides derived from a glucosyltransferase reaction; and contacting at least water, sucrose, a glucosyltransferase enzyme, and the oligosaccharides provided in the first step. Glucosyltransferase reaction compositions embodying such a method, and insoluble products thereof, are also disclosed. Yield and other product benefits can be realized when practicing the disclosed subject matter.Type: GrantFiled: September 9, 2020Date of Patent: June 27, 2023Assignee: NUTRITION & BIOSCIENCES USA 4, INC.Inventors: Kevin D. Nagy, Susan Marie Hennessey, Yefim Brun, Michael Reichman
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Patent number: 11447805Abstract: Disclosed herein are aqueous compositions comprising fructose and methods of production thereof. A method for producing an aqueous composition comprising fructose can comprise, for example, conducting an enzymatic reaction by contacting water, sucrose, and a glucosyltransferase enzyme that synthesizes poly alpha-1,3-glucan having at least 30% alpha-1,3-linkages. A soluble fraction produced by such a reaction comprises at least about 55% fructose on a dry weight basis, and can be separated from insoluble poly alpha-1,3-glucan product(s), thereby providing an aqueous composition comprising fructose.Type: GrantFiled: February 22, 2019Date of Patent: September 20, 2022Assignee: NUTRITION & BIOSCIENCES USA 4, INC.Inventors: Kevin D. Nagy, Susan Marie Hennessey, Mark S. Payne, Charles R. Powley, Bogdan Szostek, Hannu Koivikko, Juho Järvinen, Daniel Elcholtz, Jyrki Kuusisto, Tapio Timo Viljava, Stephen Thomas Breske
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Publication number: 20210395705Abstract: Disclosed herein are glucosyltransferases with modified amino acid sequences. Such engineered enzymes exhibit improved alpha-glucan product yields and/or lower leucrose yields, for example. Further disclosed are reactions and methods in which engineered glucosyltransferases are used to produce alpha-glucan.Type: ApplicationFiled: June 4, 2021Publication date: December 23, 2021Inventors: Yougen Li, MARK S. PAYNE, JARED B. PARKER, SLAVKO KRALJ, VELI ALKAN, RICHARD R. BOTT, ROBERT DICOSIMO, QIONG CHENG, ELLEN D. SEMKE, SUSAN MARIE HENNESSEY
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Patent number: 11028373Abstract: Disclosed herein are glucosyltransferases with modified amino acid sequences. Such engineered enzymes exhibit improved alpha-glucan product yields and/or lower leucrose yields, for example. Further disclosed are reactions and methods in which engineered glucosyltransferases are used to produce alpha-glucan.Type: GrantFiled: April 11, 2019Date of Patent: June 8, 2021Assignee: NUTRITION & BIOSCIENCES USA 4, INC.Inventors: Yougen Li, Mark S. Payne, Jared B. Parker, Slavko Kralj, Veli Alkan, Richard R. Bott, Robert Dicosimo, Qiong Cheng, Ellen D. Semke, Susan Marie Hennessey
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Patent number: 11015150Abstract: Compositions comprising cellulase and at least one poly alpha-1,3-glucan ether compound having a degree of substitution with an organic group of about 0.05-3.0 are disclosed. Such compositions can be dry or aqueous, the latter of which can have a viscosity of at least about 10 cPs. The disclosed composition can be in the form of a personal care product, household product, or industrial product, for example. Also disclosed are a method for preparing an aqueous composition comprising cellulase and a poly alpha-1,3-glucan ether compound, and a method of treating a material such as fabric by contacting it with this aqueous composition.Type: GrantFiled: January 15, 2019Date of Patent: May 25, 2021Assignee: NUTRITION & BIOSCIENCES USA 4, INC.Inventors: Kevin D. Nagy, Perry G. Caimi, T. Joseph Dennes, Susan Marie Hennessey, Ayrookaran J. Poulose, Jayme L. Paullin
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Publication number: 20210108240Abstract: A method for producing insoluble alpha-1,3-glucan is disclosed. Embodiments of the method comprise providing (i) oligosaccharides that comprise alpha-1,3 and alpha-1,6 glycosidic linkages, or (ii) oligosaccharides derived from a glucosyltransferase reaction; and contacting at least water, sucrose, a glucosyltransferase enzyme, and the oligosaccharides provided in the first step. Glucosyltransferase reaction compositions embodying such a method, and insoluble products thereof, are also disclosed. Yield and other product benefits can be realized when practicing the disclosed subject matter.Type: ApplicationFiled: September 9, 2020Publication date: April 15, 2021Inventors: Kevin D. Nagy, Susan Marie Hennessey, Yefim Brun, Michael Reichman
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Patent number: 10774352Abstract: A method for producing insoluble alpha-1,3-glucan is disclosed. Embodiments of the method comprise providing (i) oligosaccharides that comprise alpha-1,3 and alpha-1,6 glycosidic linkages, or (ii) oligosaccharides derived from a glucosyltransferase reaction; and contacting at least water, sucrose, a glucosyltransferase enzyme, and the oligosaccharides provided in the first step. Glucosyltransferase reaction compositions embodying such a method, and insoluble products thereof, are also disclosed. Yield and other product benefits can be realized when practicing the disclosed subject matter.Type: GrantFiled: May 22, 2018Date of Patent: September 15, 2020Assignee: DUPONT INDUSTRIAL BIOSCIENCES USA, LLCInventors: Kevin D. Nagy, Susan Marie Hennessey, Yefim Brun, Michael Reichman
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Patent number: 10774315Abstract: Disclosed herein are glucosyltransferases with modified amino acid sequences. Such engineered enzymes synthesize alpha-glucan products having increased molecular weight. Further disclosed are reactions and methods in which engineered glucosyltransferases are used to produce alpha-glucan.Type: GrantFiled: September 11, 2018Date of Patent: September 15, 2020Assignee: DUPONT INDUSTRIAL BIOSCIENCES USA, LLCInventors: Yougen Li, Ellen D. Semke, Mark S. Payne, Jared B. Parker, Susan Marie Hennessey, Slavko Kralj, Veli Alkan, Richard Bott
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Patent number: 10472657Abstract: A method is disclosed for hydrolyzing an alpha-1,3 or alpha-1,6 glucosyl-glucose linkage in a saccharide (disaccharide or oligosaccharide). This method comprises contacting the saccharide with an alpha-glucosidase enzyme such as transglucosidase under suitable conditions, during which contacting step the enzyme hydrolyzes at least one alpha-1,3 or alpha-1,6 glucosyl-glucose linkage of the saccharide. This method is useful for reducing the amount of oligosaccharides in a filtrate isolated from a glucan synthesis reaction, for example.Type: GrantFiled: May 24, 2018Date of Patent: November 12, 2019Assignee: DUPONT INDUSTRIAL BIOSCIENCES USA, LLCInventors: Kevin D. Nagy, Erwin F. Columbus-Hago, Jayarama K Shetty, Susan Marie Hennessey, Robert Dicosimo, Ling Hua, Rodrigo Ramirez, Zhongmei Tang, Zheyong Yu
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Patent number: 10428362Abstract: A method is disclosed for hydrolyzing an alpha-1,5 glucosyl-fructose linkage in a saccharide (disaccharide or oligosaccharide) such as leucrose. This method comprises contacting the saccharide with an alpha-glucosidase enzyme such as transglucosidase or glucoamylase under suitable conditions, during which contacting step the enzyme hydrolyzes at least one alpha-1,5 glucosyl-fructose linkage of the saccharide. This method is useful for reducing the amount of leucrose in a filtrate isolated from a glucan synthesis reaction, for example.Type: GrantFiled: May 10, 2018Date of Patent: October 1, 2019Assignee: E. I. DU PONT DE NEMOURS AND COMPANYInventors: Kevin D. Nagy, Erwin F. Columbus-Hago, Jayarama K. Shetty, Susan Marie Hennessey, Robert Dicosimo, Ling Hua, Rodrigo Ramirez, Zhongmei Tang, Zheyong Yu
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Publication number: 20190292528Abstract: Disclosed herein are glucosyltransferases with modified amino acid sequences. Such engineered enzymes exhibit improved alpha-glucan product yields and/or lower leucrose yields, for example. Further disclosed are reactions and methods in which engineered glucosyltransferases are used to produce alpha-glucan.Type: ApplicationFiled: April 11, 2019Publication date: September 26, 2019Inventors: Yougen Li, Mark S. Payne, Jared B. Parker, Slavko Kralj, Veli Alkan, Richard R. Bott, Robert Dicosimo, Qiong Cheng, Ellen D. Semke, Susan Marie Hennessey
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Publication number: 20190256877Abstract: Disclosed herein are aqueous compositions comprising fructose and methods of production thereof. A method for producing an aqueous composition comprising fructose can comprise, for example, conducting an enzymatic reaction by contacting water, sucrose, and a glucosyltransferase enzyme that synthesizes poly alpha-1,3-glucan having at least 30% alpha-1,3-linkages. A soluble fraction produced by such a reaction comprises at least about 55% fructose on a dry weight basis, and can be separated from insoluble poly alpha-1,3-glucan product(s), thereby providing an aqueous composition comprising fructose.Type: ApplicationFiled: February 22, 2019Publication date: August 22, 2019Inventors: KEVIN D NAGY, Susan Marie Hennessey, Mark S. Payne, Charles R. Powley, Bogdan Szostek, Hannu Koivikko, Juho Jarvinen, Daniel Elcholtz, Jyrki Kuusisto, Tapio Timo Viljava, Stephen Thomas Breske
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Patent number: 10301604Abstract: Disclosed herein are glucosyltransferases with modified amino acid sequences. Such engineered enzymes exhibit improved alpha-glucan product yields and/or lower leucrose yields, for example. Further disclosed are reactions and methods in which engineered glucosyltransferases are used to produce alpha-glucan.Type: GrantFiled: September 13, 2017Date of Patent: May 28, 2019Assignee: E I DU PONT DE NEMOURS AND COMPANYInventors: Yougen Li, Mark S. Payne, Jared B. Parker, Slavko Kralj, Veli Alkan, Richard R. Bott, Robert Dicosimo, Qiong Cheng, Ellen D. Semke, Susan Marie Hennessey
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Publication number: 20190144795Abstract: Compositions comprising cellulase and at least one poly alpha-1,3-glucan ether compound having a degree of substitution with an organic group of about 0.05-3.0 are disclosed. Such compositions can be dry or aqueous, the latter of which can have a viscosity of at least about 10 cPs. The disclosed composition can be in the form of a personal care product, household product, or industrial product, for example. Also disclosed are a method for preparing an aqueous composition comprising cellulase and a poly alpha-1,3-glucan ether compound, and a method of treating a material such as fabric by contacting it with this aqueous composition.Type: ApplicationFiled: January 15, 2019Publication date: May 16, 2019Inventors: Kevin D. Nagy, Perry G. Caimi, T. Joseph Dennes, Susan Marie Hennessey, Ayrookaran J. Poulose, Jayme L. Paullin
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Patent number: 10266861Abstract: Disclosed herein are aqueous compositions comprising fructose and methods of production thereof. A method for producing an aqueous composition comprising fructose can comprise, for example, conducting an enzymatic reaction by contacting water, sucrose, and a glucosyltransferase enzyme that synthesizes poly alpha-1,3-glucan having at least 30% alpha-1,3-linkages. A soluble fraction produced by such a reaction comprises at least about 55% fructose on a dry weight basis, and can be separated from insoluble poly alpha-1,3-glucan product(s), thereby providing an aqueous composition comprising fructose.Type: GrantFiled: December 14, 2015Date of Patent: April 23, 2019Assignees: E. I. DU PONT DE NEMOURS AND COMPANY, DUPONT NUTRITION BIOSCIENCES APSInventors: Kevin D Nagy, Susan Marie Hennessey, Mark S Payne, Charles R Powley, Bogdan Szostek, Hannu Koivikko, Juho Jarvinen, Daniel Eicholtz, Jyrki Kuusisto, Tapio Timo Viljava, Stephen Thomas Breske
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Publication number: 20190078062Abstract: Disclosed herein are glucosyltransferases with modified amino acid sequences. Such engineered enzymes synthesize alpha-glucan products having increased molecular weight. Further disclosed are reactions and methods in which engineered glucosyltransferases are used to produce alpha-glucan.Type: ApplicationFiled: September 11, 2018Publication date: March 14, 2019Inventors: YOUGEN LI, ELLEN D. SEMKE, MARK S. PAYNE, JARED B. PARKER, SUSAN MARIE HENNESSEY, SLAVKO KRALJ, VELI ALKAN, RICHARD BOTT
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Patent number: 10221378Abstract: Compositions comprising cellulase and at least one poly alpha-1,3-glucan ether compound having a degree of substitution with an organic group of about 0.05-3.0 are disclosed. Such compositions can be dry or aqueous, the latter of which can have a viscosity of at least about 10 cPs. The disclosed composition can be in the form of a personal care product, household product, or industrial product, for example. Also disclosed are a method for preparing an aqueous composition comprising cellulase and a poly alpha-1,3-glucan ether compound, and a method of treating a material such as fabric by contacting it with this aqueous composition.Type: GrantFiled: August 17, 2017Date of Patent: March 5, 2019Assignee: E I DU PONT DE NEMOURS AND COMPANYInventors: Kevin D Nagy, Perry G Caimi, T Joseph Dennes, Susan Marie Hennessey, Ayrookaran J. Poulose, Jayme L Paullin
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Publication number: 20190048376Abstract: A method is disclosed for hydrolyzing an alpha-1,3 or alpha-1,6 glucosyl-glucose linkage in a saccharide (disaccharide or oligosaccharide). This method comprises contacting the saccharide with an alpha-glucosidase enzyme such as transglucosidase under suitable conditions, during which contacting step the enzyme hydrolyzes at least one alpha-1,3 or alpha-1,6 glucosyl-glucose linkage of the saccharide. This method is useful for reducing the amount of oligosaccharides in a filtrate isolated from a glucan synthesis reaction, for example.Type: ApplicationFiled: May 24, 2018Publication date: February 14, 2019Inventors: KEVIN D. NAGY, ERWIN F. COLUMBUS-HAGO, JAYARAMA K. SHETTY, SUSAN MARIE HENNESSEY, ROBERT DICOSIMO, LING HUA, RODRIGO RAMIREZ, ZHONGMEI TANG, ZHEYONG YU
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Patent number: 10190079Abstract: Compositions comprising cellulase and at least one poly alpha-1,3-glucan ether compound having a degree of substitution with a positively charged organic group of about 0.05-3.0 are disclosed. Such compositions can be dry or aqueous, the latter of which can have a viscosity of at least about 10 cPs. The disclosed composition can be in the form of a personal care product, household product, or industrial product, for example. Also disclosed are a method for preparing an aqueous composition comprising cellulase and a poly alpha-1,3-glucan ether compound, and a method of treating a material such as fabric by contacting it with this aqueous composition.Type: GrantFiled: June 30, 2017Date of Patent: January 29, 2019Assignee: E I DU PONT DE NEMOURS AND COMPANYInventors: Kevin D. Nagy, Ayrookaran J. Poulose, T. Joseph Dennes, Perry G. Caimi, Jayme L. Paullin, Susan Marie Hennessey