Abstract: Genetic variations associated with a patient’s cancerous tumors can be indicative of potential effective treatments for treating the patient. Systems and methods for determining relationships between gene variants of a gene, the gene variants being related to one or more cancers and being correlated to a treatment response of the one or more cancers to one or more medications, are provided. The method includes accessing, using at least one processor, a database comprising information about the gene variants, the information including at least information indicative of a treatment response of a first gene variant of the gene variants to one or more treatments; categorizing the information about the gene variants within a plurality of groups; and generating hierarchical relationships between each group of the plurality of groups. In some embodiments, a patient may be treated using a treatment selected based on the generated hierarchical relationships.