Patents by Inventor Susan Napier

Susan Napier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MICELLE RELEASING THERMOSENSITIVE HYDROGELS AS A THERAPEUTIC DELIVERY SYSTEM
    Publication number: 20240139104
    Abstract: Disclosed herein are thermosensitive hydrogels including at least one thermosensitive polymer and at least one polypeptide. The hydrogels may further include one or more therapeutic and/diagnostic agents and can be used to selectively and controllably deliver such agents to specified tissues and organ systems.
    Type: Application
    Filed: March 4, 2022
    Publication date: May 2, 2024
    Inventors: Susan Napier THOMAS, Jihoon KIM
  • IN SITU THIOL-MALEIMIDE CROSSLINKED HYDROGEL FOR IMMUNE CHECKPOINT BLOCKADE DELIVERY
    Publication number: 20230257463
    Abstract: Disclosed are hydrogel compositions that can be used to deliver therapeutic agents, including therapeutic proteins, to patients in need thereof. In an embodiment, the therapeutic agent is an immune checkpoint blockade antibody, and the hydrogel is a thermoresponsive polymer crosslinked with a hydrophilic polymer.
    Type: Application
    Filed: July 13, 2021
    Publication date: August 17, 2023
    Inventors: Susan Napier THOMAS, Jihoon KIM
  • ADHESIVE SIGNATURE-BASED METHODS FOR THE ISOLATION OF CANCER-ASSOCIATED CELLS AND CELLS DERIVED THEREFROM
    Publication number: 20180298345
    Abstract: The present invention provides methods of isolating a cancer-associated cell, such as a cancer stem cell or tumor initiating cell or a cell derived therefrom, from a mixture of cells, for example, a mixture of adherent cells in culture. Cell isolation is achieved by the application of selective detachment forces.
    Type: Application
    Filed: June 23, 2016
    Publication date: October 18, 2018
    Applicant: Georgia Institute of Technology
    Inventors: Andres J. Garcia, Efrain Cermeno, Todd Christopher McDevitt, Ankur Singh, Susan Napier Thomas
  • Selectin ligands useful in the diagnosis and treatment of cancer
    Patent number: 9855349
    Abstract: The present invention provides methods and compositions useful in the diagnosis and treatment of cancer. More specifically, the present invention provides compositions and methods of use comprising a targeting composition comprising a solid substrate, an antibody composition, and optionally a chemotherapeutic agent.
    Type: Grant
    Filed: September 29, 2015
    Date of Patent: January 2, 2018
    Inventors: Konstantinos Konstantopoulos, Susan Napier Thomas
  • SELECTIN LIGANDS USEFUL IN THE DIAGNOSIS AND TREATMENT OF CANCER
    Publication number: 20160151519
    Abstract: The present invention provides methods and compositions useful in the diagnosis and treatment of cancer. More specifically, the present invention provides compositions and methods of use comprising a targeting composition comprising a solid substrate, an antibody composition, and optionally a chemotherapeutic agent.
    Type: Application
    Filed: September 29, 2015
    Publication date: June 2, 2016
    Inventors: Konstantinos Konstantopoulos, Susan Napier Thomas
  • SELECTIN LIGANDS USEFUL IN THE DIAGNOSIS AND TREATMENT OF CANCER
    Publication number: 20110003710
    Abstract: The present invention provides methods and compositions useful in the diagnosis and treatment of cancer. More specifically, the present invention provides compositions and methods of use comprising a targeting composition comprising a solid substrate, an antibody composition, and optionally a chemotherapeutic agent.
    Type: Application
    Filed: March 2, 2009
    Publication date: January 6, 2011
    Applicant: John Hopkins University
    Inventors: Konstantinos Konstantopoulos, Susan Napier Thomas
  • QUINAZOLINONE AND ISOQUINOLINONE ACETAMIDE DERIVATIVES
    Publication number: 20080090802
    Abstract: Disclosed herein are quinazolinone derivatives of formula I, or pharmaceutically acceptable salts or solvates thereof, wherein each of the substituents is given the definition as set forth in the specification and claims. Also disclosed are pharmaceutical compositions comprising quinazolinone or isoquinolinone according to the present invention and its use in therapy.
    Type: Application
    Filed: September 10, 2007
    Publication date: April 17, 2008
    Applicant: N.V. Organon
    Inventors: Jeffrey Letourneau, Patrick Jokiel, Susan Napier, Koc-Kan Ho, Michael Ohlmeyer, Duncan McArthur, Fiona Jeremiah, Paul Ratcliffe, Jurgen Schulz
  • 2-(1-OXO-1H-ISOQUINOLIN-2-YL)ACETAMIDE DERIVATIVES
    Publication number: 20080064678
    Abstract: Disclosed herein are 2-(1-oxo-1H-isoquinolin-2-yl)acetamide derivative of formula I, or pharmaceutically acceptable salts or solvates thereof wherein each of the substituents is given the definition as set forth in the specification and claims. Also disclosed are pharmaceutical compositions comprising 2-(1-oxo-1H-isoquinolin-2-yl)acetamide derivatives according to the present invention and their use in therapy.
    Type: Application
    Filed: September 10, 2007
    Publication date: March 13, 2008
    Applicant: N.V. Organon
    Inventors: Jeffrey Letourneau, Jui-Hsiang Chan, Patrick Jokiel, Michael Ohlmeyer, Irina Neagu, Christopher Riviello, John Morphy, Susan Napier, Koc-Kan Ho
  • 8-Azabicyclo[3.2.1]octane derivatives
    Publication number: 20070185156
    Abstract: The present invention relates to a 8-azabicyclo[3.2.1]octane derivative of Formula I, wherein each of the substituents is given the definition as set forth in the specification and claims, or a pharmaceutically acceptable salt thereof or solvate thereof. The present invention also relates to a pharmaceutical composition comprising an 8-azabicyclo[3.2.1]octane derivative in admixture with one or more pharmaceutically acceptable auxiliaries and to the use of the 8-azabicyclo[3.2.1]octane derivative in therapy.
    Type: Application
    Filed: December 1, 2006
    Publication date: August 9, 2007
    Applicant: N.V. Organon
    Inventors: Susan Napier, Matilda Bingham, Neil Dunbar
  • 9-Azabicyclo[3.3.1]nonane derivatives
    Publication number: 20070112019
    Abstract: The present invention relates to a 9-azabicyclo[3.3.1]nonane derivative of formula I, wherein each of the substituents is given the definition as set forth in the specification and claims, or a pharmaceutically acceptable salt or solvate thereof. The invention also relates to pharmaceutical compositions comprising said 9-azabicyclo[3.3.1]nonane derivatives and to their use in therapy.
    Type: Application
    Filed: September 29, 2006
    Publication date: May 17, 2007
    Applicant: N.V. Organon
    Inventors: Susan Napier, Matilda Bingham, Margaret Huggett, Mark Huggett, Yasuko Kiyoi, Olaf Nimz
  • 1,5,7-Trisubstituted benzimidazole derivatives and their use for modulating the gabaa receptor complex
    Publication number: 20070021482
    Abstract: This invention relates to novel 1,5,7-trisubstituted benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex.
    Type: Application
    Filed: October 20, 2004
    Publication date: January 25, 2007
    Inventors: Niall Hamilton, Susan Napier, Morag Easson, Andrew Cooke, Lene Teuber, Naheed Mirza, Frank Watjen