Patents by Inventor Susan P. McElhiney

Susan P. McElhiney has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human papillomavirus polypeptides and immunogenic compositions
    Patent number: 7378099
    Abstract: The present invention provides immunogenic and pharmaceutical compositions for the treatment and prevention of human papillomavirus (HPV)-associated cancers and in particular, cervical cancer. In particular, this invention relates to fusion proteins, and the nucleic acids encoding these fusion proteins, used to generate immune responses against HPV. Specifically, this invention provides for fusions of HPV E6 and E7 in which the E6 and/or E7 contains one or more mutations. These mutations abrogate the transformation activity of these oncogenic proteins and, thus, confer safety to the E6/E7 fusions. In addition, these fusions maintain or increase the immunogenic efficacy of E6 and E7. Any gene or protein delivery method can be used to deliver or package the immunogenic compositions of the present invention.
    Type: Grant
    Filed: January 26, 2007
    Date of Patent: May 27, 2008
    Assignee: Wyeth
    Inventors: Maria Cristina Cassetti, Larry Smith, Jeffrey K. Pullen, Susan P. McElhiney
  • Human papillomavirus polypeptides and immunogenic compositions
    Patent number: 7223408
    Abstract: The present invention provides immunogenic and pharmaceutical compositions for the treatment and prevention of human papillomavirus (HPV)-associated cancers and in particular, cervical cancer. In particular, this invention relates to fusion proteins, and the nucleic acids encoding these fusion proteins, used to generate immune responses against HPV. Specifically, this invention provides for fusions of HPV E6 and E7 in which the E6 and/or E7 contains one or more mutations. These mutations abrogate the transformation activity of these oncogenic proteins and, thus, confer safety to the E6/E7 fusions. In addition, these fusions maintain or increase the immunogenic efficacy of E6 and E7. Any gene or protein delivery method can be used to deliver or package the immunogenic compositions of the present invention.
    Type: Grant
    Filed: October 2, 2003
    Date of Patent: May 29, 2007
    Assignee: Wyeth Holdings Corporation
    Inventors: Maria Cristina Cassetti, Larry Smith, Jeffrey K. Pullen, Susan P. McElhiney