Patents by Inventor Susan T. Laing

Susan T. Laing has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS COMPRISING LIPOSOME-ENCAPSULATED THIAZOLIDINEDIONES AND LIPOSOME-ENCAPSULATED VASODILATORS, AND THEIR USE TO AMELIORATE ATHEROMA
    Publication number: 20240024237
    Abstract: Disclosed are compositions comprising a first liposome, comprising at least one lipid selected from the group consisting of saturated phospholipids, unsaturated phospholipids, mixed phospholipids, and cholesterol, and at least one vasodilator; and a second liposome, comprising at least one lipid selected from the group consisting of saturated phospholipids, unsaturated phospholipids, mixed phospholipids, and cholesterol, at least one thiazolidinedione, and at least one compound having an affinity for at least one component of an atheroma. Also disclosed are methods for forming the compositions and methods of using the compositions to ameliorate atheroma.
    Type: Application
    Filed: July 12, 2023
    Publication date: January 25, 2024
    Inventors: David D. McPherson, Shao-Ling Huang, Melvin Klegerman, Susan T. Laing, Patrick Kee, Tao Peng, Hyunggun Kim, Melanie Moody
  • COMPOSITIONS COMPRISING LIPOSOME-ENCAPSULATED THIAZOLIDINEDIONES AND LIPOSOME-ENCAPSULATED VASODILATORS, AND THEIR USE TO AMELIORATE ATHEROMA
    Publication number: 20190365649
    Abstract: Disclosed are compositions comprising a first liposome, comprising at least one lipid selected from the group consisting of saturated phospholipids, unsaturated phospholipids, mixed phospholipids, and cholesterol, and at least one vasodilator; and a second liposome, comprising at least one lipid selected from the group consisting of saturated phospholipids, unsaturated phospholipids, mixed phospholipids, and cholesterol, at least one thiazolidinedione, and at least one compound having an affinity for at least one component of an atheroma. Also disclosed are methods for forming the compositions and methods of using the compositions to ameliorate atheroma.
    Type: Application
    Filed: May 31, 2019
    Publication date: December 5, 2019
    Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: David D. McPherson, Shao-Ling Huang, Melvin Klegerman, Susan T. Laing, Patrick Kee, Tao Peng, Hyunggun Kim, Melanie Moody
  • Echogenic vehicle for clinical delivery of plasminogen activator and other fibrin-binding therapeutics to thrombi
    Patent number: 10357448
    Abstract: We disclose a composition comprising an echogenic liposome (ELIP) having an exterior surface, an interior surface, and at least one bilayer comprising at least one lipid selected from the group consisting of saturated phospholipids, unsaturated phospholipids, mixed phospholipids, and cholesterol, and a thrombolytic compound trapped by the ELIP. We also disclose a method of treating a medical condition in a patient characterized by a thrombus in the patient's vasculature, comprising administering to the patient the composition in an amount effective to reduce the size of the thrombus.
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: July 23, 2019
    Assignee: Board of Regents, The University of Texas System
    Inventors: Susan T. Laing, Shaoling Huang, David D. McPherson, Christy K. Holland, Melvin E. Klegerman
  • Echogenic Vehicle for Clinical Delivery of Plasminogen Activator and Other Fibrin-Binding Therapeutics to Thrombi
    Publication number: 20180042841
    Abstract: We disclose a composition comprising an echogenic liposome (ELIP) having an exterior surface, an interior surface, and at least one bilayer comprising at least one lipid selected from the group consisting of saturated phospholipids, unsaturated phospholipids, mixed phospholipids, and cholesterol, and a thrombolytic compound trapped by the ELIP. We also disclose a method of treating a medical condition in a patient characterized by a thrombus in the patient's vasculature, comprising administering to the patient the composition in an amount effective to reduce the size of the thrombus.
    Type: Application
    Filed: October 10, 2017
    Publication date: February 15, 2018
    Applicants: Board of Regents, The University of Texas System, Univeristy of Cincinnati
    Inventors: Susan T. Laing, Shaoling Huang, David D. McPherson, Christy K. Holland, Melvin E. Klegerman
  • Echogenic vehicle for clinical delivery of plasminogen activator and other fibrin-binding therapeutics to thrombi
    Patent number: 9814672
    Abstract: We disclose a composition comprising an echogenic liposome (ELIP) having an exterior surface, an interior surface, and at least one bilayer comprising at least one lipid selected from the group consisting of saturated phospholipids, unsaturated phospholipids, mixed phospholipids, and cholesterol, and a thrombolytic compound trapped by the ELIP. We also disclose a method of treating a medical condition in a patient characterized by a thrombus in the patient's vasculature, comprising administering to the patient the composition in an amount effective to reduce the size of the thrombus.
    Type: Grant
    Filed: March 7, 2008
    Date of Patent: November 14, 2017
    Inventors: Susan T. Laing, Shaoling Huang, David D. McPherson, Christy K. Holland, Melvin E. Klegerman
  • Echogenic Vehicle for Clinical Delivery of Plasminogen Activator and Other Fibrin-Binding Therapeutics to Thrombi
    Publication number: 20080305156
    Abstract: We disclose a composition comprising an echogenic liposome (ELIP) having an exterior surface, an interior surface, and at least one bilayer comprising at least one lipid selected from the group consisting of saturated phospholipids, unsaturated phospholipids, mixed phospholipids, and cholesterol, and a thrombolytic compound trapped by the ELIP. We also disclose a method of treating a medical condition in a patient characterized by a thrombus in the patient's vasculature, comprising administering to the patient the composition in an amount effective to reduce the size of the thrombus.
    Type: Application
    Filed: March 7, 2008
    Publication date: December 11, 2008
    Inventors: Susan T. Laing, Shaoling Huang, David D. McPherson, Christy K. Holland, Melvin E. Klegerman