Abstract: Some embodiments of the disclosure include inventive compounds (e.g., compounds of Formula (I)) and compositions (e.g., pharmaceutical compositions) which inhibit IRAK and/or FLT3 and which can be used for treating, for example, certain diseases. Some embodiments include methods of using the inventive compound (e.g., in compositions or in pharmaceutical compositions) for administering and treating (e.g., diseases such as hematopoietic cancers, myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), etc.), Additional embodiments provide disease treatment using combinations of the inventive IRAK and/or FLT3 inhibiting compounds with other therapies, such as cancer therapies.

Abstract: Datalink frames or networking packets contain protocol information in the header and optionally in the trailer of a frame or a packet. We are proposing a method in which part of or all of the protocol information corresponding to a frame or a packet is transmitted separately in another datalink frame. The “Separately Transmitted Protocol Information” is referred to as STPI. The STPI contains enough protocol information to identify the next hop node or port. STPI can be used avoid network congestion and improve link efficiency. Preferably, there will be one datalink frame or network packet corresponding to each STPI, containing the data and the rest of the protocol information and this frame/packet is referred to as DFoNP. The creation of STPI and DFoNP is done by the originator of the frame or packet such as an operating system.

Abstract: This disclosure relates to compositions comprising an antagonist of vasoactive intestinal polypeptide signaling coupled to a nanoparticle and methods of use related thereto. In certain embodiments, the nanoparticle is a poloxamer-stabilized polypropylene sulfide nanoparticle.

Abstract: This disclosure relates to methods of treating cancer or viral infections comprising administering an effective amount of a VIP antagonist in combination with an immune check-point inhibitor to a subject in need thereof. In certain embodiments, the immune check-point inhibitor is an anti-PD1 or anti-PDL1 antibody.

Abstract: This disclosure relates to methods of treating cancer or viral infections comprising administering an effective amount of a VIP antagonist in combination with an immune check-point inhibitor to a subject in need thereof. In certain embodiments, the immune check-point inhibitor is an anti-PD1 or anti-PDL1 antibody.

Abstract: A computer, including a processor and a memory, the memory including instructions to be executed by the processor to simulate behavior of a vehicle suspension component based on sampling a geometry space including vehicle suspension component hard-points using Gaussian process modeling and determine one or more vehicle suspension component geometries including vehicle suspension component hard-points based on first kinematic curves corresponding to behavior of the vehicle suspension component.

Abstract: This disclosure relates to methods of treating cancer or viral infections comprising administering an effective amount of a VIP antagonist in combination with an immune check-point inhibitor to a subject in need thereof. In certain embodiments, the immune check-point inhibitor is an anti-PD1 or anti-PDL1 antibody.

Abstract: This disclosure relates to compositions comprising an antagonist of vasoactive intestinal polypeptide signaling coupled to a nanoparticle and methods of use related thereto. In certain embodiments, the nanoparticle is a poloxamer-stabilized polypropylene sulfide nanoparticle.

Abstract: Cleaning compositions with improved rinsing properties which provide a surface with reduced spotting after rinsing are provided. The preferred compositions contain at least one surfactant selected from the group consisting of anionic surfactants, nonionic surfactants and combinations thereof; inorganic nanoparticles; a carrier dispersible polymer containing cationic, anionic and nonionic residues; and a carrier, preferably water. Methods for cleaning including applying to a surface a cleaning composition of the invention, and rinsing the surface, preferably with water, is also provided.

Abstract: An embodiment is directed to a computerized method in vehicle transport. A request regarding transport of a vehicle is received over a computer network. Electronic information regarding a pick-up location and electronic information regarding a drop-off location for transport of the vehicle are accessed, and based on the electronic information regarding a pick-up location and information regarding a drop-off location for transport of the vehicle quotation of cost for transfer of the vehicle is automatically generated. A quotation for cost for transport of the vehicle is transmitted electronically to the user, over a computer network. A request to transport the vehicle is received, and based on a request to transport the vehicle, an electronic request to a transporter to transport the vehicle is automatically initiated. Also described is an internet-based system, an automated system in vehicles sales, as well as other methods and systems.

Abstract: An embodiment of the invention is directed to a method for computer network-based sale of vehicles. An access group data structure is created. The access group data structure includes structure that defines association of web sites, users and vehicles associated with an access group. Whether vehicles are visible on respective web sites is controlled based on the access group, and access by the user is allowed to respective items in the access group based on whether a user is associated with the access group. Another embodiment includes providing an access group object, wherein the access group object includes properties that define association of web sites, users and vehicles associated with an access group. Another embodiment is directed to a computerized system for vehicle sale including a web server.

Abstract: Systems and methods are provided for schema mapping and the transformation of data. In accordance with one implementation, a computer-implemented method is provided that includes the steps of simultaneously displaying to a user, via a graphical user interface, layouts of the first and second documents, wherein the first and second documents have different data schemas and are instantiated with elements containing data values, and acquiring one or more associations from the user to map a first element of the first document to a second element of the second document. The method further includes the steps of indicating to the user a second association between elements in the first and second documents based on the association acquired from the user, and storing the association including the layout data corresponding to the first and second elements.

Abstract: Systems and methods are provided for schema mapping and the transformation of data. In accordance with one implementation, a computer-implemented method is provided that comprises loading a conceptual model, wherein the conceptual model contains at least one conceptual object, loading a source schema and a source instance, converting the source schema and the source instance into a source model, and acquiring, from the user, at least one forward mapping usable to map at least a source attribute of the source model to a conceptual attribute of the conceptual model, wherein the forward mapping includes a mapping formula. Further, the method may include loading a target schema and a target instance, converting the target schema and the target instance into a target model, and reverse mapping at least one of conceptual attributes of the conceptual model to a target attribute of the target model based on the forward mapping and the mapping formula.

Abstract: A device for carrying a fluid dispensing unit includes a container for receiving the fluid dispensing unit and a chain connected to the container for carrying the container and retaining the dispensing unit in the container. The dispensing unit can be secured to the chain by sandwiching the chain between a cap and the dispensing unit itself.