Abstract: The invention provides a method of treating or preventing a pathologic state in a mammal. The method comprises administering to the mammal a promoter of T-cell expansion and an inducer of CD40 stimulation, wherein CD40 is stimulated on cells of the immune system. The promoter of T-cell expansion and inducer of CD40 stimulation are administered in synergistically effective amounts to treat or prevent the pathologic state in the mammal. The invention also provides a method of assessing the effectiveness of treatment of a pathologic state in a mammal, wherein the mammal has been administered a promoter of T-cell expansion and an inducer of CD40 stimulation, wherein CD40 is stimulated on cells of the immune system.

Abstract: Novel human interleukin-2 (IL-2) muteins or variants thereof, and nucleic acid molecules and variants thereof are provided. Methods for producing these muteins as well as methods for stimulating the immune system of an animal are also disclosed. In addition, the invention provides recombinant expression vectors comprising the nucleic acid molecules of this invention and host cells into which expression vectors have been introduced. Pharmaceutical compositions are included comprising a therapeutically effective amount of a human IL-2 mutein of the invention and a pharmaceutically acceptable carrier. The IL-2 muteins have lower toxicity than native IL-2 or Proleukin® IL-2, while maintaining or enhancing NK cell-mediated effects, and can be used in pharmaceutical compositions for use in treatment of cancer, and in stimulating the immune response.

Abstract: Methods for treating B-cell lymphomas, such as non-Hodgkin's lymphoma (NHL) are disclosed. The methods use a combination therapy of a chemotherapeutic agent, an IL-2 and, optionally, an anti-CD20 antibody.

Abstract: Methods for predicting patient tolerability to therapeutic agents, such as cytokines, lymphokines and immunotoxins, are disclosed. The methods utilize an in vitro model of vascular leak syndrome (VLS) to assess the effect of the agent in question on the permeability of large proteins across confluent monolayers of endothelial cells (EC).

Abstract: Methods for the use of Fc gamma receptor (Fc?R) polymorphisms as a diagnostic for intervention with interleukin-2 (IL-2) immunotherapy are provided. The methods comprise detecting the allelic pattern of an Fc?RIIIA gene or Fc?RIIA gene of an individual, and determining whether the allelic pattern is predictive of a positive therapeutic response to IL-2 immunotherapy. The presence of the Fc?RIIIA 158F/F homozygous genotype, and/or the presence of one or both copies of the Fc?RIIIA 48L allele, and/or the presence of one or both copies of the Fc?RIIA 131R allele is predictive of a positive therapeutic response to IL-2 immunotherapy, and therefore indicative of medical intervention with IL-2 immunotherapy for treatment of an immune disorder. The diagnostic method finds use in identifying those individuals whose immune function can be improved by treatment with IL-2 immunotherapy, particularly for individuals with cancer.

Abstract: Novel human interleukin-2 (IL-2) muteins or variants thereof, and nucleic acid molecules and variants thereof are provided. Methods for producing these muteins as well as methods for stimulating the immune system of an animal are also disclosed. In addition, the invention provides recombinant expression vectors comprising the nucleic acid molecules of this invention and host cells into which expression vectors have been introduced. Pharmaceutical compositions are included comprising a therapeutically effective amount of a human IL-2 mutein of the invention and a pharmaceutically acceptable carrier. The IL-2 muteins have lower toxicity than native IL-2 or Proleukin® IL-2, while maintaining or enhancing NK cell-mediated effects, and can be used in pharmaceutical compositions for use in treatment of cancer, and in stimulating the immune response.

Abstract: An apparatus providing a sleeping surface is described. A mattress support includes a honeycomb core formed of undulated strips of resilient thermoplastic material, thermal compression bonded together and expanded to form cell walls defining a plurality of contiguous regularly shaped cells. The honeycomb core has a top face and a bottom face, and includes a thermal compression planarizing deformation of the top face and the bottom face. A first facing sheet of resilient thermoplastic material is bonded to the top face of the honeycomb core, and a second facing sheet of resilient thermoplastic material is bonded to the bottom face of the honeycomb core. The mattress support is configured to support the mattress and a human being positioned on top of the mattress, the mattress positioned on top of the first facing sheet of the mattress support.

Abstract: Disclosed are chimeric HPV L1 proteins and virus like particles comprising the same which are capable of generating high titer neutralizing antibody responses against at least two HPV types. The disclosed chimeric HPV L1 proteins and VLPs are useful as therapeutic and prophylactic reagents, as well as reagents for diagnosing papillomavirus infection.

Abstract: Methods and apparatus directed to a multi-layer honeycomb sole. A footwear item in accordance with the invention includes a sole that includes a top layer attached to a bottom layer such that their edges are fused together. The top layer includes a first honeycomb core having an exposed surface that includes contours configured to accommodate contours of a foot. The first honeycomb core includes unsealed cells that have walls with perforations. The bottom layer includes a second honeycomb core that includes sealed cells.

Abstract: A multi-section mattress or mattress overlay including a first generally rectangular section made from a first honeycomb core having a first core face and a second core face, the first core having a first facing sheet bonded to one of the first and second core faces, a second generally rectangular section made from a second honeycomb core having a third core face and a fourth core face, the second core having a second facing sheet bonded to one of the third and fourth core faces, the second section being positioned with one side thereof immediately adjacent an opposing side of the first section; and a seam joining the first and second sections together along the lengths of the one side and the opposing side, the seam being formed by bonding a portion of the first face extending along the one side to a portion of the third face extending along the opposing side, and by orienting the bonded portions of the first and third faces such that they extend away from a plane including the first and third faces and towa

Abstract: Methods and apparatus directed to a multi-layer honeycomb sole. A footwear item in accordance with the invention includes a sole that includes a top layer attached to a bottom layer such that their edges are fused together. The top layer includes a first honeycomb core having an exposed surface that includes contours configured to accommodate contours of a foot. The first honeycomb core includes unsealed cells that have walls with perforations. The bottom layer includes a second honeycomb core that includes sealed cells.