Patents by Inventor Susana Martinez
Susana Martinez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12201362Abstract: Systems and methods for detecting a traumatic brain injury (TBI). The system comprises a sensing arrangement and a control unit. The sensing arrangement collects eye movement data of a user. The control unit is in communication with the sensing arrangement and configured to compare the eye movement data to one or more baseline measurements of eye movement dynamics. The control unit is also configured to generate an alert indicating the presence or severity of the TBI for delivery to control unit administrator if the eye movement data diverges from one or more of the baseline measurements by a threshold amount.Type: GrantFiled: June 26, 2023Date of Patent: January 21, 2025Assignee: DIGNITY HEALTHInventors: Stephen L. Macknik, Susana Martinez-Conde
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Publication number: 20240188879Abstract: A system and method of detecting eye movements of a subject for the diagnosis of neurological disorders. The method includes tracking eye movements of the subject, identifying microsaccades from the tracked eye movements, and characterizing microsaccade dynamics of the identified microsaccades to determine one or more parameters, such as microsaccade direction, microsaccade velocity, microsaccade magnitude, microsaccadic peak velocity-magnitude relationship, microsaccade duration, and intersaccadic intervals. The method also includes comparing the one or more determined parameters with a corresponding control parameter, assessing the comparison to determine differences between the one or more determined parameters and the corresponding control parameters, and generating a report including the diagnosis of neurological disorder based on the assessment.Type: ApplicationFiled: February 19, 2024Publication date: June 13, 2024Applicants: DIGNITY HEALTH, LE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Stephen L. Macknik, Susana Martinez-Conde, Zoi Kapoula, Jorge Otero-Millan
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Publication number: 20240165421Abstract: There is set forth herein: an implant adapted for implantation in a user having a neocortex at least part of which has been made responsive to light, the neocortex including a plurality of columns forming an array of cortical columns capable of description by a cortical map characterizing, identifying or defining a location or topographical relationship and placement for respective ones of the plurality of columns; wherein the implant includes an emitter array; wherein the emitter array includes a plurality of emitters, wherein respective ones of the plurality of emitters are configured to emit light toward the array of cortical columns.Type: ApplicationFiled: February 12, 2022Publication date: May 23, 2024Applicant: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORKInventors: Stephen L. MACKNIK, Susana MARTINEZ-CONDE, Edward WHITE, Satyavolu S. PAPA RAO, Spyridon GALIS, John N. CARTER, Olivya CABALLERO
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Patent number: 11903720Abstract: A system and method of detecting eye movements of a subject for the diagnosis of neurological disorders. The method includes tracking eye movements of the subject, identifying microsaccades from the tracked eye movements, and characterizing microsaccade dynamics of the identified microsaccades to determine one or more parameters, such as microsaccade direction, microsaccade velocity, microsaccade magnitude, microsaccadic peak velocity-magnitude relationship, microsaccade duration, and intersaccadic intervals. The method also includes comparing the one or more determined parameters with a corresponding control parameter, assessing the comparison to determine differences between the one or more determined parameters and the corresponding control parameters, and generating a report including the diagnosis of neurological disorder based on the assessment.Type: GrantFiled: January 13, 2020Date of Patent: February 20, 2024Assignees: DIGNITY HEALTH, LE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Stephen L. Macknik, Susana Martinez-Conde, Zoi Kapoula, Jorge Otero-Millan
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Patent number: 11880441Abstract: Provided is a method of granting access, including compiling a training profile of each of two or more persons, wherein the training profile includes one or more oculomotor features exhibited during one or more tasks, associating a training profile of one of the two or more persons with a permission, detecting a testing profile of one of the two or more persons, wherein the testing profile includes one or more of the one or more oculomotor features exhibited by during one or more of the one or more tasks, identifying a target profile, granting access if and only if the target profile is associated with the permission, wherein the one or more tasks are selected from fixation, saccade speed, saccade accuracy, visually-guided saccades, anti-saccades, memory-guided saccades, free viewing, pursuit.Type: GrantFiled: August 26, 2019Date of Patent: January 23, 2024Assignee: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORKInventors: Nicolas Brunet, Susana Martinez-Conde, Stephen Macknik, Robert Alexander
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Publication number: 20230389840Abstract: Systems and methods for detecting deceptive intent of a subject include observing eye movements of the subject and correlating the observed movements to known baseline neurophysiological indicators of deception. A detection system may record eye movement data from the subject, compare the eye movement data to a data model comprising threshold eye movement data samples, and from the comparison make a determination whether or not the subject is lying. The detection system may create an alert if deception is detected. The eye movements detected include saccadic and intersaccadic parameters such as intersaccadic drift velocity. Measurements may be collected in situ with a field testing device, such as a non-invasive, non-contact device attached to the subject's computing device and configured to non-obtrusively record the eye movement data.Type: ApplicationFiled: August 22, 2023Publication date: December 7, 2023Inventors: Stephen L. Macknik, Susana Martinez-Conde, Richard E. Dale, Richard Besserman, Troy Lee McDaniel
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Publication number: 20230329547Abstract: Systems and methods for detecting a traumatic brain injury (TBI). The system comprises a sensing arrangement and a control unit. The sensing arrangement collects eye movement data of a user. The control unit is in communication with the sensing arrangement and configured to compare the eye movement data to one or more baseline measurements of eye movement dynamics. The control unit is also configured to generate an alert indicating the presence or severity of the TBI for delivery to control unit administrator if the eye movement data diverges from one or more of the baseline measurements by a threshold amount.Type: ApplicationFiled: June 26, 2023Publication date: October 19, 2023Applicant: DIGNITY HEALTHInventors: Stephen L. Macknik, Susana Martinez-Conde
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Patent number: 11759134Abstract: Systems and methods for detecting deceptive intent of a subject include observing eye movements of the subject and correlating the observed movements to known baseline neurophysiological indicators of deception. A detection system may record eye movement data from the subject, compare the eye movement data to a data model comprising threshold eye movement data samples, and from the comparison make a determination whether or not the subject is lying. The detection system may create an alert if deception is detected. The eye movements detected include saccadic and intersaccadic parameters such as intersaccadic drift velocity. Measurements may be collected in situ with a field testing device, such as a non-invasive, non-contact device attached to the subject's computing device and configured to non-obtrusively record the eye movement data.Type: GrantFiled: August 14, 2020Date of Patent: September 19, 2023Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY DIGNITY HEALTHInventors: Stephen L. Macknik, Susana Martinez-Conde, Richard E. Dale, Richard Besserman, Troy Lee McDaniel
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Patent number: 11707193Abstract: Systems and methods for detecting a traumatic brain injury (TBI). The system comprises a sensing arrangement and a control unit. The sensing arrangement collects eye movement data of a user. The control unit is in communication with the sensing arrangement and configured to compare the eye movement data to one or more baseline measurements of eye movement dynamics. The control unit is also configured to generate an alert indicating the presence or severity of the TBI for delivery to control unit administrator if the eye movement data diverges from one or more of the baseline measurements by a threshold amount.Type: GrantFiled: October 5, 2020Date of Patent: July 25, 2023Assignee: DIGNITY HEALTHInventors: Stephen L. Macknik, Susana Martinez-Conde
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Publication number: 20230200641Abstract: A system and method for determining a subject's attentional response to a stimulus. The method includes measuring microsaccadic eye movement dynamics of the subject, detecting whether a microsaccadic signature (a suppression in microsaccadic rate) is present in the measured microsaccadic eye movement relative to a time of the stimulus, and correlating the subject's attentional response to the stimulus based on the detection. The method further includes determining that the stimulus was sensed if the microsaccadic signature is present and determining that the stimulus was not sensed if the microsaccadic signature is absent.Type: ApplicationFiled: March 6, 2023Publication date: June 29, 2023Applicant: Dignity HealthInventors: Jorge Otero-Millan, Stephen L. Macknik, Susana Martinez-Conde
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Patent number: 11602273Abstract: A system and method for determining a subject's attentional response to a stimulus. The method includes measuring microsaccadic eye movement dynamics of the subject, detecting whether a microsaccadic signature (a suppression in microsaccadic rate) is present in the measured microsaccadic eye movement relative to a time of the stimulus, and correlating the subject's attentional response to the stimulus based on the detection. The method further includes determining that the stimulus was sensed if the microsaccadic signature is present and determining that the stimulus was not sensed if the microsaccadic signature is absent.Type: GrantFiled: December 29, 2017Date of Patent: March 14, 2023Assignee: DIGNITY HEALTHInventors: Jorge Otero-Millan, Stephen L. Macknik, Susana Martinez-Conde
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Publication number: 20230009372Abstract: Systems and methods for detecting onset, presence, and progression of particular states, including intoxication, include observing eye movements of a subject and correlating the observed movements to known baseline neurophysiological indicators of intoxication. A detection system may record eye movement data from a user, compare the eye movement data to a data model comprising threshold eye movement data samples, and from the comparison make a determination whether or not intoxication or impairment is present. The detection system may alert the user to take corrective action if onset or presence of a dangerous condition is detected. The eye movements detected include saccadic and intersaccadic parameters such as intersaccadic drift velocity. Measurements may be collected in situ with a field testing device. An interactive application may be provided on a user device to provoke the desired eye movements during recording.Type: ApplicationFiled: May 31, 2022Publication date: January 12, 2023Inventors: Stephen L. Macknik, Susana Martinez-Conde, Richard E. Dale, Richard Besserman, Troy Lee McDaniel
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Patent number: 11350921Abstract: Provided is an implant, including a chamber having an interior radius wherein the interior radius has a flange, a cover slip, a cup, a setting member, a securing member, a resistance member, and an opposing member, wherein the cover slip, cup, resisting member, and setting member are attached to one another, the setting member sets on a flange and the securing member secures the setting member to the flange, the resistance member includes a flexibility and a longitudinal axis with a length wherein the flexibility permits modification of the length, and the opposing member sets a minimum length of the longitudinal axis. Also provided is a method of using said implant including affixing the chamber to a skull of a mammal.Type: GrantFiled: April 1, 2019Date of Patent: June 7, 2022Assignee: The Research Foundation for the State University of New YorkInventors: Stephen Macknik, Olivya Caballero, Manuel Ledo, Susana Martinez-Conde
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Patent number: 11344226Abstract: Systems and methods for detecting onset, presence, and progression of particular states, including intoxication, include observing eye movements of a subject and correlating the observed movements to known baseline neurophysiological indicators of intoxication. A detection system may record eye movement data from a user, compare the eye movement data to a data model comprising threshold eye movement data samples, and from the comparison make a determination whether or not intoxication or impairment is present. The detection system may alert the user to take corrective action if onset or presence of a dangerous condition is detected. The eye movements detected include saccadic and intersaccadic parameters such as intersaccadic drift velocity. Measurements may be collected in situ with a field testing device. An interactive application may be provided on a user device to provoke the desired eye movements during recording.Type: GrantFiled: May 31, 2019Date of Patent: May 31, 2022Assignees: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY, DIGNITY HEALTHInventors: Stephen L. Macknik, Susana Martinez-Conde, Richard E. Dale, Richard Besserman, Troy Lee McDaniel
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Patent number: 11123444Abstract: The present disclosure is directed to methods and a diagnostic kit for producing pericyte information from a subject for identifying and/or treating a subject condition. In one aspect, a method for identifying a subject condition is provided. The method includes administering intravenously to a subject an effective amount of a solution comprising fluorescent markers to selectively label a plurality of pericytes in the subject's body. The method also includes acquiring fluorescence signals originating from labeled pericytes to produce pericyte information associated with tissues of the subject's body. The method further includes generating a report identifying a subject condition using the pericyte information. In some aspects, a treatment may be adapted using the identified subject condition.Type: GrantFiled: October 16, 2014Date of Patent: September 21, 2021Assignee: Dignity HealthInventors: Stephen L. Macknik, Susana Martinez-Conde, Hector Rieiro
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Publication number: 20210248348Abstract: Provided is a method of granting access, including compiling a training profile of each of two or more persons, wherein the training profile includes one or more oculomotor features exhibited during one or more tasks, associating a training profile of one of the two or more persons with a permission, detecting a testing profile of one of the two or more persons, wherein the testing profile includes one or more of the one or more oculomotor features exhibited by during one or more of the one or more tasks, identifying a target profile, granting access if and only if the target profile is associated with the permission, wherein the one or more tasks are selected from fixation, saccade speed, saccade accuracy, visually-guided saccades, anti-saccades, memory-guided saccades, free viewing, pursuit.Type: ApplicationFiled: August 26, 2019Publication date: August 12, 2021Applicant: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORKInventors: Nicolas BRUNET, Susana MARTINEZ-CONDE, Stephen MACKNIK, Robert ALEXANDER
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Publication number: 20210161383Abstract: Provided is a method of detecting neural activity, including inducing neurons of a subject to express two or more polypeptides each comprising an amino acid sequence represented by one of SEQ ID NOs:13-24, wherein inducing comprises stimulating interneuronally different relative levels of expression of the two or more polypeptides; applying coelenterazine to the subject; applying a first stimulation of neural activity to the subject; detecting a first spatiotemporal and spectral pattern of electromagnetic radiation emitted by neurons of the subject in response to the first stimulation; recording the first spatiotemporal and spectral pattern of electromagnetic radiation in a computer memory; applying a second stimulation of neural activity to the subject; detecting a second spatiotemporal and spectral pattern of electromagnetic radiation emitted by neurons of the subject in response to the second stimulation; comparing the second spatiotemporal and spectral pattern of electromagnetic radiation to the first spaType: ApplicationFiled: June 12, 2019Publication date: June 3, 2021Applicants: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, CORNELL UNIVERSITYInventors: Stephen MACKNIK, Susana MARTINEZ-CONDE, Nozomi NISHIMURA, Christopher SCHAFFER, Mitch PENDER
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Patent number: 11013411Abstract: Provided is a method of detecting neural activity, including inducing neurons of a subject to express two or more polypeptides each comprising an amino acid sequence represented by one of SEQ ID NOs:13-24, wherein inducing comprises stimulating interneuronally different relative levels of expression of the two or more polypeptides; applying coelenterazine to the subject; applying a first stimulation of neural activity to the subject; detecting a first spatiotemporal and spectral pattern of electromagnetic radiation emitted by neurons of the subject in response to the first stimulation; recording the first spatiotemporal and spectral pattern of electromagnetic radiation in a computer memory; applying a second stimulation of neural activity to the subject; detecting a second spatiotemporal and spectral pattern of electromagnetic radiation emitted by neurons of the subject in response to the second stimulation; comparing the second spatiotemporal and spectral pattern of electromagnetic radiation to the first spaType: GrantFiled: June 12, 2019Date of Patent: May 25, 2021Assignees: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, CORNELL UNIVERSITYInventors: Stephen Macknik, Susana Martinez-Conde, Nozomi Nishimura, Christopher Schaffer, Mitch Pender
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Publication number: 20210059589Abstract: Systems and methods for detecting deceptive intent of a subject include observing eye movements of the subject and correlating the observed movements to known baseline neurophysiological indicators of deception. A detection system may record eye movement data from the subject, compare the eye movement data to a data model comprising threshold eye movement data samples, and from the comparison make a determination whether or not the subject is lying. The detection system may create an alert if deception is detected. The eye movements detected include saccadic and intersaccadic parameters such as intersaccadic drift velocity. Measurements may be collected in situ with a field testing device, such as a non-invasive, non-contact device attached to the subject's computing device and configured to non-obtrusively record the eye movement data.Type: ApplicationFiled: August 14, 2020Publication date: March 4, 2021Inventors: Stephen L. Macknik, Susana Martinez-Conde, Richard E. Dale, Richard Besserman, Troy Lee McDaniel
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Publication number: 20210015361Abstract: Systems and methods for detecting a traumatic brain injury (TBI). The system comprises a sensing arrangement and a control unit. The sensing arrangement collects eye movement data of a user. The control unit is in communication with the sensing arrangement and configured to compare the eye movement data to one or more baseline measurements of eye movement dynamics. The control unit is also configured to generate an alert indicating the presence or severity of the TBI for delivery to control unit administrator if the eye movement data diverges from one or more of the baseline measurements by a threshold amount.Type: ApplicationFiled: October 5, 2020Publication date: January 21, 2021Inventors: Stephen L. Macknik, Susana Martinez-Conde