Patents by Inventor Susana Martinez-Conde

Susana Martinez-Conde has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11123444
    Abstract: The present disclosure is directed to methods and a diagnostic kit for producing pericyte information from a subject for identifying and/or treating a subject condition. In one aspect, a method for identifying a subject condition is provided. The method includes administering intravenously to a subject an effective amount of a solution comprising fluorescent markers to selectively label a plurality of pericytes in the subject's body. The method also includes acquiring fluorescence signals originating from labeled pericytes to produce pericyte information associated with tissues of the subject's body. The method further includes generating a report identifying a subject condition using the pericyte information. In some aspects, a treatment may be adapted using the identified subject condition.
    Type: Grant
    Filed: October 16, 2014
    Date of Patent: September 21, 2021
    Assignee: Dignity Health
    Inventors: Stephen L. Macknik, Susana Martinez-Conde, Hector Rieiro
  • Publication number: 20210248348
    Abstract: Provided is a method of granting access, including compiling a training profile of each of two or more persons, wherein the training profile includes one or more oculomotor features exhibited during one or more tasks, associating a training profile of one of the two or more persons with a permission, detecting a testing profile of one of the two or more persons, wherein the testing profile includes one or more of the one or more oculomotor features exhibited by during one or more of the one or more tasks, identifying a target profile, granting access if and only if the target profile is associated with the permission, wherein the one or more tasks are selected from fixation, saccade speed, saccade accuracy, visually-guided saccades, anti-saccades, memory-guided saccades, free viewing, pursuit.
    Type: Application
    Filed: August 26, 2019
    Publication date: August 12, 2021
    Applicant: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Nicolas BRUNET, Susana MARTINEZ-CONDE, Stephen MACKNIK, Robert ALEXANDER
  • Publication number: 20210161383
    Abstract: Provided is a method of detecting neural activity, including inducing neurons of a subject to express two or more polypeptides each comprising an amino acid sequence represented by one of SEQ ID NOs:13-24, wherein inducing comprises stimulating interneuronally different relative levels of expression of the two or more polypeptides; applying coelenterazine to the subject; applying a first stimulation of neural activity to the subject; detecting a first spatiotemporal and spectral pattern of electromagnetic radiation emitted by neurons of the subject in response to the first stimulation; recording the first spatiotemporal and spectral pattern of electromagnetic radiation in a computer memory; applying a second stimulation of neural activity to the subject; detecting a second spatiotemporal and spectral pattern of electromagnetic radiation emitted by neurons of the subject in response to the second stimulation; comparing the second spatiotemporal and spectral pattern of electromagnetic radiation to the first spa
    Type: Application
    Filed: June 12, 2019
    Publication date: June 3, 2021
    Applicants: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, CORNELL UNIVERSITY
    Inventors: Stephen MACKNIK, Susana MARTINEZ-CONDE, Nozomi NISHIMURA, Christopher SCHAFFER, Mitch PENDER
  • Patent number: 11013411
    Abstract: Provided is a method of detecting neural activity, including inducing neurons of a subject to express two or more polypeptides each comprising an amino acid sequence represented by one of SEQ ID NOs:13-24, wherein inducing comprises stimulating interneuronally different relative levels of expression of the two or more polypeptides; applying coelenterazine to the subject; applying a first stimulation of neural activity to the subject; detecting a first spatiotemporal and spectral pattern of electromagnetic radiation emitted by neurons of the subject in response to the first stimulation; recording the first spatiotemporal and spectral pattern of electromagnetic radiation in a computer memory; applying a second stimulation of neural activity to the subject; detecting a second spatiotemporal and spectral pattern of electromagnetic radiation emitted by neurons of the subject in response to the second stimulation; comparing the second spatiotemporal and spectral pattern of electromagnetic radiation to the first spa
    Type: Grant
    Filed: June 12, 2019
    Date of Patent: May 25, 2021
    Assignees: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, CORNELL UNIVERSITY
    Inventors: Stephen Macknik, Susana Martinez-Conde, Nozomi Nishimura, Christopher Schaffer, Mitch Pender
  • Publication number: 20210059589
    Abstract: Systems and methods for detecting deceptive intent of a subject include observing eye movements of the subject and correlating the observed movements to known baseline neurophysiological indicators of deception. A detection system may record eye movement data from the subject, compare the eye movement data to a data model comprising threshold eye movement data samples, and from the comparison make a determination whether or not the subject is lying. The detection system may create an alert if deception is detected. The eye movements detected include saccadic and intersaccadic parameters such as intersaccadic drift velocity. Measurements may be collected in situ with a field testing device, such as a non-invasive, non-contact device attached to the subject's computing device and configured to non-obtrusively record the eye movement data.
    Type: Application
    Filed: August 14, 2020
    Publication date: March 4, 2021
    Inventors: Stephen L. Macknik, Susana Martinez-Conde, Richard E. Dale, Richard Besserman, Troy Lee McDaniel
  • Publication number: 20210015361
    Abstract: Systems and methods for detecting a traumatic brain injury (TBI). The system comprises a sensing arrangement and a control unit. The sensing arrangement collects eye movement data of a user. The control unit is in communication with the sensing arrangement and configured to compare the eye movement data to one or more baseline measurements of eye movement dynamics. The control unit is also configured to generate an alert indicating the presence or severity of the TBI for delivery to control unit administrator if the eye movement data diverges from one or more of the baseline measurements by a threshold amount.
    Type: Application
    Filed: October 5, 2020
    Publication date: January 21, 2021
    Inventors: Stephen L. Macknik, Susana Martinez-Conde
  • Patent number: 10791926
    Abstract: Systems and methods for detecting a traumatic brain injury (TBI). The system comprises a sensing arrangement and a control unit. The sensing arrangement collects eye movement data of a user. The control unit is in communication with the sensing arrangement and configured to compare the eye movement data to one or more baseline measurements of eye movement dynamics. The control unit is also configured to generate an alert indicating the presence or severity of the TBI for delivery to control unit administrator if the eye movement data diverges from one or more of the baseline measurements by a threshold amount.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: October 6, 2020
    Assignee: Dignity Health
    Inventors: Stephen L. Macknik, Susana Martinez-Conde
  • Patent number: 10743806
    Abstract: Systems and methods for detecting deceptive intent of a subject include observing eye movements of the subject and correlating the observed movements to known baseline neurophysiological indicators of deception. A detection system may record eye movement data from the subject, compare the eye movement data to a data model comprising threshold eye movement data samples, and from the comparison make a determination whether or not the subject is lying. The detection system may create an alert if deception is detected. The eye movements detected include saccadic and intersaccadic parameters such as intersaccadic drift velocity. Measurements may be collected in situ with a field testing device, such as a non-invasive, non-contact device attached to the subject's computing device and configured to non-obtrusively record the eye movement data.
    Type: Grant
    Filed: June 11, 2015
    Date of Patent: August 18, 2020
    Assignees: Dignity Health, Arizona Board of Regents on behalf of Arizona State University
    Inventors: Stephen L. Macknik, Susana Martinez-Conde, Richard E. Dale, Richard Besserman, Troy Lee McDaniel
  • Publication number: 20200146611
    Abstract: A system and method of detecting eye movements of a subject for the diagnosis of neurological disorders. The method includes tracking eye movements of the subject, identifying microsaccades from the tracked eye movements, and characterizing microsaccade dynamics of the identified microsaccades to determine one or more parameters, such as microsaccade direction, microsaccade velocity, microsaccade magnitude, microsaccadic peak velocity-magnitude relationship, microsaccade duration, and intersaccadic intervals. The method also includes comparing the one or more determined parameters with a corresponding control parameter, assessing the comparison to determine differences between the one or more determined parameters and the corresponding control parameters, and generating a report including the diagnosis of neurological disorder based on the assessment.
    Type: Application
    Filed: January 13, 2020
    Publication date: May 14, 2020
    Inventors: Stephen L. Macknik, Susana Martinez-Conde, Zoi Kapoula, Jorge Otero-Millan
  • Publication number: 20200093474
    Abstract: Provided is an implant, including a chamber having an interior radius wherein the interior radius has a flange, a cover slip, a cup, a setting member, a securing member, a resistance member, and an opposing member, wherein the cover slip, cup, resisting member, and setting member are attached to one another, the setting member sets on a flange and the securing member secures the setting member to the flange, the resistance member includes a flexibility and a longitudinal axis with a length wherein the flexibility permits modification of the length, and the opposing member sets a minimum length of the longitudinal axis. Also provided is a method of using said implant including affixing the chamber to a skull of a mammal.
    Type: Application
    Filed: April 1, 2019
    Publication date: March 26, 2020
    Applicant: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Stephen MACKNIK, Olivya CABALLERO, Manuel LEDO, Susana MARTINEZ-CONDE
  • Publication number: 20200022622
    Abstract: Systems and methods for detecting onset, presence, and progression of particular states, including intoxication, include observing eye movements of a subject and correlating the observed movements to known baseline neurophysiological indicators of intoxication. A detection system may record eye movement data from a user, compare the eye movement data to a data model comprising threshold eye movement data samples, and from the comparison make a determination whether or not intoxication or impairment is present. The detection system may alert the user to take corrective action if onset or presence of a dangerous condition is detected. The eye movements detected include saccadic and intersaccadic parameters such as intersaccadic drift velocity. Measurements may be collected in situ with a field testing device. An interactive application may be provided on a user device to provoke the desired eye movements during recording.
    Type: Application
    Filed: May 31, 2019
    Publication date: January 23, 2020
    Inventors: Stephen L. Macknik, Susana Martinez-Conde, Richard E. Dale, Richard Besserman, Troy Lee McDaniel
  • Patent number: 10537276
    Abstract: A system and method of detecting eye movements of a subject for the diagnosis of neurological disorders. The method includes tracking eye movements of the subject, identifying microsaccades from the tracked eye movements, and characterizing microsaccade dynamics of the identified microsaccades to determine one or more parameters, such as microsaccade direction, microsaccade velocity, microsaccade magnitude, microsaccadic peak velocity-magnitude relationship, microsaccade duration, and intersaccadic intervals. The method also includes comparing the one or more determined parameters with a corresponding control parameter, assessing the comparison to determine differences between the one or more determined parameters and the corresponding control parameters, and generating a report including the diagnosis of neurological disorder based on the assessment.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: January 21, 2020
    Assignees: DIGNITY HEALTH, LE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Stephen L. Macknik, Susana Martinez-Conde, Zoi Kapoula, Jorge Otero-Millan
  • Patent number: 10376183
    Abstract: Systems and methods for detecting onset, presence, and progression of particular states, including intoxication, include observing eye movements of a subject and correlating the observed movements to known baseline neurophysiological indicators of intoxication. A detection system may record eye movement data from a user, compare the eye movement data to a data model comprising threshold eye movement data samples, and from the comparison make a determination whether or not intoxication or impairment is present. The detection system may alert the user to take corrective action if onset or presence of a dangerous condition is detected. The eye movements detected include saccadic and intersaccadic parameters such as intersaccadic drift velocity. Measurements may be collected in situ with a field testing device. An interactive application may be provided on a user device to provoke the desired eye movements during recording.
    Type: Grant
    Filed: April 27, 2015
    Date of Patent: August 13, 2019
    Assignees: Dignity Health, Arizona Board of Regents on Behalf of Arizona State University
    Inventors: Stephen L. Macknik, Susana Martinez-Conde, Richard E. Dale, Richard Besserman, Tropy McDaniel
  • Publication number: 20190159672
    Abstract: Systems and methods for detecting a traumatic brain injury (TBI). The system comprises a sensing arrangement and a control unit. The sensing arrangement collects eye movement data of a user. The control unit is in communication with the sensing arrangement and configured to compare the eye movement data to one or more baseline measurements of eye movement dynamics. The control unit is also configured to generate an alert indicating the presence or severity of the TBI for delivery to control unit administrator if the eye movement data diverges from one or more of the baseline measurements by a threshold amount.
    Type: Application
    Filed: January 31, 2019
    Publication date: May 30, 2019
    Inventors: Stephen L. Macknik, Susana Martinez-Conde
  • Patent number: 10292584
    Abstract: Systems and methods for detecting onset, presence, and progression of particular states, including hypoxia, include observing eye movements of a subject to and correlating the observed movements to known baseline or hypoxic conditions. A detection system may record eye movement data from a user, compare the eye movement data to a data model comprising threshold eye movement data samples, and from the comparison make a determination whether or not hypoxia, fatigue, or other detrimental conditions are present. The detection system may alert the user to take corrective action if onset or presence of a dangerous condition is detected. The eye movements detected include saccadic and intersaccadic parameters such as intersaccadic drift velocity. Measurements may be collected in situ while the subject is performing normal duties, processed to determine indicators of detrimental conditions, and reported to the subject within a few seconds.
    Type: Grant
    Filed: January 29, 2015
    Date of Patent: May 21, 2019
    Assignee: Dignity Health
    Inventors: Leandro Luigi Di Stasi, Susana Martinez-Conde, Raul Cabestrero, Andres Catena, Michael McCamy, Stephen L. Macknik
  • Patent number: 10231617
    Abstract: Systems and methods for detecting a traumatic brain injury (TBI). The system comprises a sensing arrangement and a control unit. The sensing arrangement collects eye movement data of a user. The control unit is in communication with the sensing arrangement and configured to compare the eye movement data to one or more baseline measurements of eye movement dynamics. The control unit is also configured to generate an alert indicating the presence or severity of the TBI for delivery to control unit administrator if the eye movement data diverges from one or more of the baseline measurements by a threshold amount.
    Type: Grant
    Filed: August 20, 2015
    Date of Patent: March 19, 2019
    Assignee: Dignity Health
    Inventors: Stephen L. Macknik, Susana Martinez-Conde
  • Publication number: 20180235531
    Abstract: A system and method of detecting eye movements of a subject for the diagnosis of neurological disorders. The method includes tracking eye movements of the subject, identifying microsaccades from the tracked eye movements, and characterizing microsaccade dynamics of the identified microsaccades to determine one or more parameters, such as microsaccade direction, microsaccade velocity, microsaccade magnitude, microsaccadic peak velocity-magnitude relationship, microsaccade duration, and intersaccadic intervals. The method also includes comparing the one or more determined parameters with a corresponding control parameter, assessing the comparison to determine differences between the one or more determined parameters and the corresponding control parameters, and generating a report including the diagnosis of neurological disorder based on the assessment.
    Type: Application
    Filed: April 20, 2018
    Publication date: August 23, 2018
    Inventors: Stephen L. Macknik, Susana Martinez-Conde, Zoi Kapoula, Jorge Otero-Millan
  • Patent number: 9962119
    Abstract: A system and method of detecting eye movements of a subject for the diagnosis of neurological disorders. The method includes tracking eye movements of the subject, identifying microsaccades from the tracked eye movements, and characterizing microsaccade dynamics of the identified microsaccades to determine one or more parameters, such as microsaccade direction, microsaccade velocity, microsaccade magnitude, microsaccadic peak velocity-magnitude relationship, microsaccade duration, and infersaccatic intervals. The method also includes comparing the one or more determined parameters with a corresponding control parameter, assessing the comparison to determine differences between the one or more determined parameters and the corresponding control parameters, and generating a report including the diagnosis of neurological disorder based on the assessment.
    Type: Grant
    Filed: April 23, 2014
    Date of Patent: May 8, 2018
    Assignees: DIGNITY HEALTH, LE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Stephen L. Macknik, Susana Martinez-Conde, Zoi Kapoula, Jorge Otero-Millan
  • Publication number: 20180116507
    Abstract: A system and method for determining a subject's attentional response to a stimulus. The method includes measuring microsaccadic eye movement dynamics of the subject, detecting whether a microsaccadic signature (a suppression in microsaccadic rate) is present in the measured microsaccadic eye movement relative to a time of the stimulus, and correlating the subject's attentional response to the stimulus based on the detection. The method further includes determining that the stimulus was sensed if the microsaccadic signature is present and determining that the stimulus was not sensed if the microsaccadic signature is absent.
    Type: Application
    Filed: December 29, 2017
    Publication date: May 3, 2018
    Inventors: Jorge Otero-Millan, Stephen L. Macknik, Susana Martinez-Conde
  • Patent number: 9854966
    Abstract: A system and method for determining a subject's attentional response to a stimulus. The method includes measuring microsaccadic eye movement dynamics of the subject, detecting whether a microsaccadic signature (a suppression in microsaccadic rate) is present in the measured microsaccadic eye movement relative to a time of the stimulus, and correlating the subject's attentional response to the stimulus based on the detection. The method further includes determining that the stimulus was sensed if the microsaccadic signature is present and determining that the stimulus was not sensed if the microsaccadic signature is absent.
    Type: Grant
    Filed: November 23, 2012
    Date of Patent: January 2, 2018
    Assignee: Dignity Health
    Inventors: Jorge Otero-Millan, Stephen L. Macknik, Susana Martinez-Conde