Patents by Inventor Susanna Chiocca

Susanna Chiocca has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chicken embryo lethal (CELO) virus
    Patent number: 6773709
    Abstract: A CELO virus obtained by in vitro manipulation of a plasmid-cloned CELO virus DNA is suitable for the production of vectors for gene therapy and as a vaccine against infectious diseases in humans and animals, particularly birds.
    Type: Grant
    Filed: October 5, 2001
    Date of Patent: August 10, 2004
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Adam Baker, Matthew Cotten, Susanna Chiocca, Robert Kurzbauer, Gotthold Schaffner
  • Chicken embryo lethal orphan (CELO) virus
    Publication number: 20020081279
    Abstract: A CELO virus obtained by in vitro manipulation of a plasmid-cloned CELO virus DNA is suitable for the production of vectors for gene therapy and as a vaccine against infectious diseases in humans and animals, particularly birds.
    Type: Application
    Filed: October 5, 2001
    Publication date: June 27, 2002
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Adam Baker, Matthew Cotten, Susanna Chiocca, Robert Kurzbauer, Gotthold Schaffner
  • Method for introducing foreign material into higher eukaryotic cells
    Publication number: 20020049313
    Abstract: The toxicity problems which occur when foreign material is introduced into higher eukaryotic cells, particularly during transfection with DNA, are countered by causing gene products to be expressed in the cell, which block the apoptosis triggered by the transfection process, and/or by treating the cells with anti-inflammatory substances. Preferably, Bcl-2, E1B 19K or an anti-apoptotically active gene of chicken adenovirus CELO is used as the anti-apoptosis gene whilst the inflammatory substance used is adenovirus VA1, which is introduced into the cell in the form of VA1-DNA. Using these methods, long-lasting gene expression can be achieved.
    Type: Application
    Filed: June 29, 2001
    Publication date: April 25, 2002
    Inventors: Matthew Cotten, Adam Baker, Susanna Chiocca
  • Chicken embryo lethal orphan (CELO) virus
    Patent number: 6335016
    Abstract: A CELO virus obtained by in vitro manipulation of a plasmid-cloned CELO virus DNA is suitable for the production of vectors for gene therapy and as a vaccine against infectious diseases in humans and animals, particularly birds.
    Type: Grant
    Filed: January 12, 1999
    Date of Patent: January 1, 2002
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Adam Baker, Matthew Cotten, Susanna Chiocca, Robert Kurzbauer, Gotthold Schaffner
  • Chicken embryo lethal orphan (CELO) virus GAM-1
    Patent number: 6284880
    Abstract: The toxicity problems which occur when foreign material is introduced into higher eukaryotic cells, particularly during transfection with DNA, are countered by causing gene products to be expressed in the cell, which block the apoptosis triggered by the transfection process, and/or by treating the cells with anti-inflammatory substances. Preferably, Bcl-2, E1B 19K or an anti-apoptotically active gene of chicken adenovirus CELO is used as the anti-apoptosis gene whilst the inflammatory substance used is adenovirus VA1, which is introduced into the cell in the form of VA1-DNA. Using these methods, long-lasting gene expression can be achieved.
    Type: Grant
    Filed: February 14, 1997
    Date of Patent: September 4, 2001
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Matthew Cotten, Adam Baker, Susanna Chiocca
  • Endosomolytically active particles
    Patent number: 5789230
    Abstract: Endosomolytically active virus-like particle which is made up of units of capsid proteins of viruses or virus-like particles, the capsid protein units having a membrane-active peptide sequence. The particles are suitable as components of compositions for transporting nucleic acids into higher eukaryotic cells by receptor-mediated endocytosis.
    Type: Grant
    Filed: April 12, 1996
    Date of Patent: August 4, 1998
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Matthew Cotten, Susanna Chiocca, Gotthold Schaffner, Ernst Wagner