Patents by Inventor Susanna Rybak

Susanna Rybak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Specificity grafting of a murine antibody onto a human framework
    Publication number: 20060194276
    Abstract: The current invention provides new human variable chain framework regions and humanized antibodies comprising the framework regions. The invention also provides a new method of identifying framework acceptor regions in framework sequences for backmutation to graft a donor sequence to the human framework.
    Type: Application
    Filed: June 17, 2003
    Publication date: August 31, 2006
    Applicants: THE GOVERMMENT of the USA as Represented by the Secretary of the Dept, of Health and Human Service, University of Reading
    Inventors: Jurgen Krauss, Michaela Arndt, Andrew Martin, Susanna Rybak
  • Biological materials and uses thereof
    Publication number: 20060193849
    Abstract: A modified antibody molecule which selectively binds to a specific target, the antibody molecule being modified at at least one amino acid residue that determines antigen binding selectivity and/or affinity, characterised in that the modified antibody molecule exhibits a greater stability than an unmodified parent antibody molecule which selectively binds to the target. Also described are nucleotide sequences encoding, vectors, host cells and composition containing and uses of such antibodies, antibody fragments or antibody derivatives.
    Type: Application
    Filed: February 25, 2005
    Publication date: August 31, 2006
    Inventors: Juergen Krauss, Nigel Courtenay-Luck, Susanna Rybak
  • Transgenically produced fusion proteins
    Publication number: 20060026695
    Abstract: A method of making a transgenic fusion protein. The method inlcudes providing a transgenic animal which includes a transgene which provides for the expression of the fusion protein; allowing the transgene to be expressed; and, recovering the fusion protein, from the milk of the transgenic animal.
    Type: Application
    Filed: June 24, 2005
    Publication date: February 2, 2006
    Inventors: Michael Edge, Dan Pollock, Yann Echelard, Harry Meade, Susanna Rybak
  • Immunotoxins directed against malignant cells
    Publication number: 20050249738
    Abstract: The present invention relates to immunotoxins, that effectively kill malignant cells having a given surface marker and nucleic acid constructs encoding them. These reagents comprise a toxic moiety that is derived from a Rana pipiens protein having ribonucleolytic activity linked to an antibody capable of specific binding with a chosen tumor cell.
    Type: Application
    Filed: July 11, 2005
    Publication date: November 10, 2005
    Applicants: The Govt. of the U.S.A as represented by the Sect. of the Dept. of Health & Human Services, Inc, Immunomedics, Inc.
    Inventors: David Goldenberg, Susanna Rybak, Dianne Newton
  • Vectors for delivering viral and oncogenic inhibitors
    Patent number: 6953687
    Abstract: Cell transformation vectors for inhibiting HIV and tumor growth are provided. Optionally, the vectors encode RNAses such as EDN. Cells transduced by the vectors and methods of transforming cells (in vitro and in vivo) using the vectors are also provided.
    Type: Grant
    Filed: July 17, 1997
    Date of Patent: October 11, 2005
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Susanna Rybak, Andrea Cara, Gabriele Luca Gusella, Dianne Newton
  • Vectors for delivering viral and oncogenic inhibitors
    Publication number: 20050214258
    Abstract: Cell transformation vectors for inhibiting HIV and tumor growth are provided. Optionally, the vectors encode RNAses such as EDN. Cells transduced by the vectors and methods of transforming cells (in vitro and in vivo) using the vectors are also provided.
    Type: Application
    Filed: January 24, 2005
    Publication date: September 29, 2005
    Applicant: The Government of the USA as represented by the Secretary of the Dept. of Health & Human Services
    Inventors: Susanna Rybak, Andrea Cara, Gabriele Gusella, Dianne Newton