Patents by Inventor Susanna Vaccaro

Susanna Vaccaro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the production and purification of the collagenase enzyme from
    Patent number: 11613743
    Abstract: The present invention claims a novel process for the production and purification of microbial collagenase (Microbial Collagenase EC 3.4.24.3) produced by the non-pathogenic aerobic bacterium Vibrio alginolyticus chemovar. iophagus (NCIMB Number: 11038, synonym LMG 3418, hereinafter called Vibrio alginolyticus), which said process provides high production levels of collagenase with a stable, reproducible, cheap fermentation process. The collagenase produced from Vibrio alginolyticus according to the process described herein also presents a specific activity superior to that of other microbial collagenases, is stable in aqueous solution, and can be frozen without significant damage.
    Type: Grant
    Filed: July 30, 2020
    Date of Patent: March 28, 2023
    Assignee: FIDIA FARMACEUTICI S.p.A.
    Inventors: Susanna Vaccaro, Michele Caputo, Christian Cuppari, Giovanni Gennari
  • NANOSYSTEMS FOR CONTROLLED TRANSPORT OF ACTIVE MOLECULES FOR DIAGNOSTIC, PROGNOSTIC AND THERAPEUTIC PURPOSES
    Publication number: 20230056857
    Abstract: Disclosed is a nanoparticle system consisting of a polymer support or substrate in the form of nanoparticles to which a hydrolase enzyme able to degrade hyaluronic acid and one or more biologically and/or pharmacologically active molecules are covalently bonded, its preparation process and its uses in the diagnostic, prognostic and therapeutic fields.
    Type: Application
    Filed: October 28, 2022
    Publication date: February 23, 2023
    Applicants: FIDIA FARMACEUTICI S.P.A., NANOGETIC S.L.
    Inventors: Rosario Maria SANCHEZ MARTIN, Salvatore PERNAGALLO, Juan Diego UNCITI BROCETA, Luciano MESSINA, Susanna VACCARO, Laura PILOTTO
  • Nanosystems for controlled transport of active molecules for diagnostic, prognostic and therapeutic purposes
    Patent number: 11510995
    Abstract: Disclosed is a nanoparticle system consisting of a polymer support or substrate in the form of nanoparticles to which a hydrolase enzyme able to degrade hyaluronic acid and one or more biologically and/or pharmacologically active molecules are covalently bonded, its preparation process and its uses in the diagnostic, prognostic and therapeutic fields.
    Type: Grant
    Filed: December 20, 2016
    Date of Patent: November 29, 2022
    Assignees: FIDIA FARMACEUTICI S.P.A., NANOGETIC S.L.
    Inventors: Rosario Maria Sanchez Martin, Salvatore Pernagallo, Juan Diego Unciti Broceta, Luciano Messina, Susanna Vaccaro, Laura Pilotto
  • PHARMACEUTICAL COMPOSITIONS CONTAINING HYALURONIC ACID AND CARNOSINE AND RELATIVE USE
    Publication number: 20220031797
    Abstract: Pharmaceutical compositions are described containing Hyaluronic Acid and Carnosine for use in the treatment and prevention of osteoarthritis (OA) and for the treatment of rheumatoid arthritis (RA).
    Type: Application
    Filed: September 23, 2021
    Publication date: February 3, 2022
    Applicant: FIDIA FARMACEUTICI S.P.A.
    Inventors: Antonella Schiavinato, Valentina Greco, Luciano Messina, Susanna Vaccaro, Enrico Rizzarelli, Sebastiano Sciuto
  • Pharmaceutical compositions containing hyaluronic acid and collagenase for the topical treatment of wounds, burns and ulcers
    Patent number: 11040089
    Abstract: The present invention concerns new compositions containing hyaluronic acid or the derivatives thereof in association with the proteolytic enzyme collagenase (and relative pharmaceutical formulations) for the preparation of a dressing for topical treatment of various kinds of wounds, burns of varying depth, pressure sores, vascular ulcers and diabetic foot ulcers as well as for the treatment of hypertrophic and keloid scars.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: June 22, 2021
    Assignee: FIDIA FARMACEUTICI S.P.A
    Inventors: Susanna Vaccaro, Giovanni Gennari, Lanfranco Callegaro, Antonio Giannelli, Salvatore Caruso
  • PROCESS FOR THE PRODUCTION AND PURIFICATION OF THE COLLAGENASE ENZYME FROM VIBRIO ALGINOLYTICUS
    Publication number: 20200354707
    Abstract: The present invention claims a novel process for the production and purification of microbial collagenase (Microbial Collagenase EC 3.4.24.3) produced by the non-pathogenic aerobic bacterium Vibrio alginolyticus chemovar. iophagus (NCIMB Number: 11038, synonym LMG 3418, hereinafter called Vibrio alginolyticus), which said process provides high production levels of collagenase with a stable, reproducible, cheap fermentation process. The collagenase produced from Vibrio alginolyticus according to the process described herein also presents a specific activity superior to that of other microbial collagenases, is stable in aqueous solution, and can be frozen without significant damage.
    Type: Application
    Filed: July 30, 2020
    Publication date: November 12, 2020
    Applicant: FIDIA FARMACEUTICI S.P.A.
    Inventors: Susanna VACCARO, Michele CAPUTO, Christian CUPPARI, Giovanni GENNARI
  • PHARMACEUTICAL COMPOSITIONS CONTAINING HYALURONIC ACID AND CARNOSINE AND RELATIVE USE
    Publication number: 20200289604
    Abstract: Pharmaceutical compositions are described containing Hyaluronic Acid and Carnosine for use in the treatment and prevention of osteoarthritis (OA) and for the treatment of rheumatoid arthritis (RA).
    Type: Application
    Filed: October 3, 2018
    Publication date: September 17, 2020
    Applicant: FIDIA FARMACEUTICI S.P.A.
    Inventors: Antonella SCHIAVINATO, Valentina GRECO, Luciano MESSINA, Susanna VACCARO, Enrico RIZZARELLI, Sebastiano SCIUTO
  • Process for the production and purification of the collagenase enzyme from vibrio alginolyticus
    Patent number: 10774319
    Abstract: The present invention claims a novel process for the production and purification of microbial collagenase (Microbial Collagenase EC 3.4.24.3) produced by the non-pathogenic aerobic bacterium Vibrio alginolyticus chemovar. iophagus (NCIMB Number: 11038, synonym LMG 3418, hereinafter called Vibrio alginolyticus), which said process provides high production levels of collagenase with a stable, reproducible, cheap fermentation process. The collagenase produced from Vibrio alginolyticus according to the process described herein also presents a specific activity superior to that of other microbial collagenases, is stable in aqueous solution, and can be frozen without significant damage.
    Type: Grant
    Filed: July 12, 2017
    Date of Patent: September 15, 2020
    Assignee: FIDIA FARMACEUTICI S.P.A.
    Inventors: Susanna Vaccaro, Michele Caputo, Christian Cuppari, Giovanni Gennari
  • Bacterial hyaluronidase and process for its production
    Patent number: 10400229
    Abstract: The present invention relates to a hyaluronidase from S. koganeiensis, applications thereof and a method for the production thereof.
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: September 3, 2019
    Assignee: FIDIA FARMACEUTICI S.P.A.
    Inventors: Luciano Messina, Luca Musumeci, Susanna Vaccaro
  • Derivatives obtained from hyaluronic acid and carnosine
    Patent number: 10364299
    Abstract: The present invention relates to a derivative of carnosine (?-alanyl-L-histidine) having formula (1), obtained by the functionalization of hyaluronic acid with carnosine.
    Type: Grant
    Filed: July 30, 2015
    Date of Patent: July 30, 2019
    Assignees: CONSIGLIO NAZIONALE DELLE RICERCHE, FIDIA FARMACEUTICI S.P.A.
    Inventors: Sebastiano Sciuto, Valentina Greco, Enrico Rizzarelli, Francesco Bellia, Valeria Lanza, Susanna Vaccaro, Luciano Messina
  • Extracellular hyaluronidase from
    Patent number: 10208300
    Abstract: A process for preparing Streptomyces koganeiensis ATCC 31394 hyaluronidase by obtaining hyaluronidase having molecular weight of 21.6 kDalton, which has hyaluronidase activity and stability markedly higher than those of the hyaluronidase obtained from such microorganism to date.
    Type: Grant
    Filed: August 2, 2016
    Date of Patent: February 19, 2019
    Assignee: FIDIA FARMACEUTICI S.P.A.
    Inventors: Luciano Messina, Susanna Vaccaro, Salvatore Caruso, Giovanni Gennari
  • BACTERIAL HYALURONIDASE AND PROCESS FOR ITS PRODUCTION
    Publication number: 20180362949
    Abstract: The present invention relates to a hyaluronidase from S. koganeiensis, applications thereof and a method for the production thereof.
    Type: Application
    Filed: October 10, 2017
    Publication date: December 20, 2018
    Applicant: FIDIA FARMACEUTICI S.P.A.
    Inventors: Luciano MESSINA, Luca MUSUMECI, Susanna VACCARO
  • NANOSYSTEMS FOR CONTROLLED TRANSPORT OF ACTIVE MOLECULES FOR DIAGNOSTIC, PROGNOSTIC AND THERAPEUTIC PURPOSES
    Publication number: 20180360990
    Abstract: Disclosed is a nanoparticle system consisting of a polymer support or substrate in the form of nanoparticles to which a hydrolase enzyme able to degrade hyaluronic acid and one or more biologically and/or pharmacologically active molecules are covalently bonded, its preparation process and its uses in the diagnostic, prognostic and therapeutic fields.
    Type: Application
    Filed: December 20, 2016
    Publication date: December 20, 2018
    Applicants: FIDIA FARMACEUTICI S.P.A., NANOGETIC S.L.
    Inventors: Rosario Maria SANCHEZ MARTIN, Salvatore PERNAGALLO, Juan Diego UNCITI BROCETA, Luciano MESSINA, Susanna VACCARO, Laura PILOTTO
  • Process for the production of hyaluronic acid in or
    Patent number: 10017802
    Abstract: The present invention relates to a method for the production of hyaluronic acid (HA) in Bacillus subtilis and Escherichia coli through plasmid vectors wherein the gene is under the control of strong promoter Pgrac, and a system for the selection of stable bacterial strains for the production of high levels of hyaluronic acid.
    Type: Grant
    Filed: February 17, 2016
    Date of Patent: July 10, 2018
    Assignee: FIDIA FARMACEUTICI S.P.A.
    Inventors: Vincenza Corsa, Alessandro Negro, Susanna Vaccaro, Luciano Messina
  • Bacterial hyaluronidase and process for its production
    Patent number: 9822351
    Abstract: The present invention relates to a hyaluronidase from S. koganeiensis, applications thereof and a method for the production thereof.
    Type: Grant
    Filed: June 13, 2014
    Date of Patent: November 21, 2017
    Assignee: FIDIA FARMACEUTICI S.P.A.
    Inventors: Luciano Messina, Luca Musumeci, Susanna Vaccaro
  • NEW PROCESS FOR THE PRODUCTION AND PURIFICATION OF THE COLLAGENASE ENZYME FROM VIBRIO ALGINOLYTICUS
    Publication number: 20170314005
    Abstract: The present invention claims a novel process for the production and purification of microbial collagenase (Microbial Collagenase EC 3.4.24.3) produced by the non-pathogenic aerobic bacterium Vibrio alginolyticus chemovar. iophagus (NCIMB Number: 11038, synonym LMG 3418, hereinafter called Vibrio alginolyticus), which said process provides high production levels of collagenase with a stable, reproducible, cheap fermentation process. The collagenase produced from Vibrio alginolyticus according to the process described herein also presents a specific activity superior to that of other microbial collagenases, is stable in aqueous solution, and can be frozen without significant damage.
    Type: Application
    Filed: July 12, 2017
    Publication date: November 2, 2017
    Applicant: FIDIA FARMACEUTICI S.P.A.
    Inventors: Susanna VACCARO, Michele CAPUTO, Christian CUPPARI, Giovanni GENNARI
  • DERIVATIVES OBTAINED FROM HYALURONIC ACID AND CARNOSINE
    Publication number: 20170246306
    Abstract: The present invention relates to a derivative of carnosine (?-alanyl-L-histidine) having formula (1), obtained by the functionalization of hyaluronic acid with carnosine.
    Type: Application
    Filed: July 30, 2015
    Publication date: August 31, 2017
    Applicants: CONSIGLIO NAZIONALE DELLE RICERCHE, FIDIA FARMACEUTICI S.P.A.
    Inventors: Sebastiano SCIUTO, Valentina GRECO, Enrico RIZZARELLI, Francesco BELLIA, Valeria LANZA, Susanna VACCARO, Luciano MESSINA
  • Process for the production and purification of the collagenase enzyme from vibrio alginolyticus
    Patent number: 9738883
    Abstract: The present invention claims a novel process for the production and purification of microbial collagenase (Microbial Collagenase EC 3.4.24.3) produced by the non-pathogenic aerobic bacterium Vibrio alginolyticus chemovar. iophagus (NCIMB Number: 1 1038, synonym LMG 3418, hereinafter called Vibrio alginolyticus), which said process provides high production levels of collagenase with a stable, reproducible, cheap fermentation process. The collagenase produced from Vibrio alginolyticus according to the process described herein also presents a specific activity superior to that of other microbial collagenases, is stable in aqueous solution, and can be frozen without significant damage.
    Type: Grant
    Filed: April 17, 2013
    Date of Patent: August 22, 2017
    Assignee: FIDIA FARMACEUTICALS S.P.A.
    Inventors: Susanna Vaccaro, Michele Caputo, Christian Cuppari, Giovanni Gennari
  • PHARMACEUTICAL COMPOSITIONS CONTAINING HYALURONIC ACID AND COLLAGENASE FOR THE TOPICAL TREATMENT OF WOUNDS, BURNS AND ULCERS
    Publication number: 20170209552
    Abstract: The present invention concerns new compositions containing hyaluronic acid or the derivatives thereof in association with the proteolytic enzyme collagenase (and relative pharmaceutical formulations) for the preparation of a dressing for topical treatment of various kinds of wounds, burns of varying depth, pressure sores, vascular ulcers and diabetic foot ulcers as well as for the treatment of hypertrophic and keloid scars.
    Type: Application
    Filed: February 2, 2017
    Publication date: July 27, 2017
    Applicant: Fidia Farmaceutici S.p.A.
    Inventors: Susanna VACCARO, Giovanni GENNARI, Lanfranco CALLEGARO, Antonio GIANNELLI, Salvatore CARUSO
  • EXTRACELLULAR HYALURONIDASE FROM STREPTOMYCES KOGANEIENSIS
    Publication number: 20170101634
    Abstract: A process for preparing Streptomyces koganeiensis ATCC 31394 hyaluronidase includes obtaining hyaluronidase having molecular weight of 21.6 kDalton, which has hyaluronidase activity and stability markedly higher than those of the hyaluronidase obtained from such microorganism to date.
    Type: Application
    Filed: August 2, 2016
    Publication date: April 13, 2017
    Applicant: FIDIA FARMACEUTICI S.P.A.
    Inventors: Luciano MESSINA, Susanna VACCARO, Salvatore CARUSO, Giovanni GENNARI