Patents by Inventor Susanne BONSMANN

Susanne BONSMANN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL 6,7-DIHYDRO-4H-PYRAZOLO[1,5-A]PYRAZINE INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)
    Publication number: 20220363686
    Abstract: The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.
    Type: Application
    Filed: November 1, 2019
    Publication date: November 17, 2022
    Applicant: AiCuris GmbH & Co. KG
    Inventors: Alastair DONALD, Andreas URBAN, Susanne BONSMANN, Jasper SPRINGER, Anita WEGERT
  • NOVEL INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITUS B VIRUS (HBV)
    Publication number: 20220306647
    Abstract: The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.
    Type: Application
    Filed: April 29, 2020
    Publication date: September 29, 2022
    Applicant: AICURIS GMBH & CO. KG
    Inventors: Susanne BONSMANN, Alastair DONALD, Andreas URBAN, Burkhard KLENKE, Jasper SPRINGER
  • NOVEL PHENYL AND PYRIDYL UREAS ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)
    Publication number: 20220227785
    Abstract: The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.
    Type: Application
    Filed: April 29, 2020
    Publication date: July 21, 2022
    Applicant: AICURIS GMBH & CO. KG
    Inventors: Susanne BONSMANN, Alastair DONALD, Burkhard KLENKE, Andreas URBAN, Jasper SPRINGER
  • NOVEL INDOLIZINE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)
    Publication number: 20220227789
    Abstract: The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.
    Type: Application
    Filed: April 29, 2020
    Publication date: July 21, 2022
    Applicant: AiCuris GmbH & Co. KG
    Inventors: Susanne BONSMANN, Alastair DONALD, Andreas URBAN, Jasper SPRINGER, Elena DETTA
  • NOVEL OXALYL PIPERAZINES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)
    Publication number: 20220227737
    Abstract: The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.
    Type: Application
    Filed: April 29, 2020
    Publication date: July 21, 2022
    Applicant: AiCuris GmbH & Co. KG
    Inventors: Susanne BONSMANN, Alastair DONALD, Andreas URBAN, Thomas GOLDNER, Miquel Angel PERICAS BRONDO, Esther Alza BARRIOS, Elena DETTA, Justine RAYMOND
  • MALEATE SALT OF THE FREE BASE OF N-[5-(AMINOSULFONYL)-4-METHYL-1,3-THIAZOL-2-YL]-N-METHYL-2-[4-(2-PYRIDINYL)-PHENYL]-ACETAMIDE, PHARMACEUTICAL FORMULATIONS, METHODS OF MANUFACTURE AND USES THEREOF
    Publication number: 20220152009
    Abstract: The present invention relates to the field of anti-viral active agents, particularly to salts, more particularly to a maleate salt of the free base of N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)-phenyl]-acetamide, to pharmaceutical formulations thereof as well as to methods for the production of these salts. The present invention also relates to the use of theses salts and of respective pharmaceutical formulations thereof in methods of treatment and/or prevention of human herpes simplex virus infections, particularly infections caused by HSV-1 and HSV-2.
    Type: Application
    Filed: January 26, 2022
    Publication date: May 19, 2022
    Applicant: AICURIS GMBH & CO. KG
    Inventors: Yogeshwar BACHHAV, Wilfried SCHWAB, Alexander BIRKMANN, Susanne BONSMANN, Thomas GOLDNER
  • 6,7-DIHYDRO-4H-PYRAZOLO[1,5-A]PYRAZINE INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)
    Publication number: 20220081444
    Abstract: The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.
    Type: Application
    Filed: November 1, 2019
    Publication date: March 17, 2022
    Applicant: AiCuris GmbH & Co. KG
    Inventors: Alastair DONALD, Andreas URBAN, Susanne BONSMANN, Jasper SPRINGER, Anita WEGERT
  • Highly active amino-thiazole substituted indole-2-carboxamides active against the hepatitis B virus (HBV)
    Patent number: 11267825
    Abstract: The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.
    Type: Grant
    Filed: November 2, 2018
    Date of Patent: March 8, 2022
    Assignee: AICURIS GMBH & CO. KG
    Inventors: Alastair Donald, Andreas Urban, Susanne Bonsmann, Anita Wegert, Christiaan Gremmen, Jasper Springer
  • Maleate salt of the free base of N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)-phenyl]-acetamide, pharmaceutical formulations, methods of manufacture and uses thereof for the treatment of herpes viruses
    Patent number: 11266636
    Abstract: The present invention relates to the field of anti-viral active agents, particularly to salts, more particularly to a maleate salt of the free base of N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)-phenyl]-acetamide, to pharmaceutical formulations thereof as well as to methods for the production of these salts. The present invention also relates to the use of theses salts and of respective pharmaceutical formulations thereof in methods of treatment and/or prevention of human herpes simplex virus infections, particularly infections caused by HSV-1 and HSV-2.
    Type: Grant
    Filed: November 28, 2017
    Date of Patent: March 8, 2022
    Assignee: AICURIS GMBH & CO. KG
    Inventors: Yogeshwar Bachhav, Wilfried Schwab, Alexander Birkmann, Susanne Bonsmann, Thomas Goldner
  • Highly active pyrazolo-piperidine substituted indole-2-carboxamides active against the hepatitis B virus (HBV)
    Patent number: 11236087
    Abstract: The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.
    Type: Grant
    Filed: November 2, 2018
    Date of Patent: February 1, 2022
    Assignee: AiCuris GmbH & Co. KG
    Inventors: Alastair Donald, Andreas Urban, Susanne Bonsmann, Anita Wegert, Jasper Springer
  • NOVEL UREA 6,7-DIHYDRO-4H-PYRAZOLO[4,3-C]PYRIDINES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)
    Publication number: 20220009922
    Abstract: The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.
    Type: Application
    Filed: November 1, 2019
    Publication date: January 13, 2022
    Applicant: AiCuris GmbH & Co. KG
    Inventors: Alastair DONALD, Andreas URBAN, Susanne BONSMANN
  • NOVEL UREA 6,7-DIHYDRO-4H-PYRAZOLO[1,5-A]PYRAZINES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)
    Publication number: 20220009931
    Abstract: The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.
    Type: Application
    Filed: November 1, 2019
    Publication date: January 13, 2022
    Applicant: AICURIS GMBH & CO. KG
    Inventors: Alastair DONALD, Andreas URBAN, Susanne BONSMANN
  • NOVEL UREA 6,7-DIHYDRO-4H-THIAZOLE[5,4-C]PYRIDINES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)
    Publication number: 20220009945
    Abstract: The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.
    Type: Application
    Filed: November 1, 2019
    Publication date: January 13, 2022
    Applicant: AICURIS GMBH & CO. KG
    Inventors: Alastair DONALD, Andreas URBAN, Susanne BONSMANN
  • Intravaginally applicable devices comprising antiviral compounds
    Patent number: 11213516
    Abstract: The present invention relates to field of intravaginally applicable devices that release antiviral compounds. In particular, the present invention relates to vaginal rings comprising a matrix releasing at least one antivirally active compound, in particular anti-herpetic compound N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)-phenyl]-acetamide (in the following also referred to as “Pritelivir”) or salts thereof. The present invention therefore relates to the treatment and prevention of herpes infections.
    Type: Grant
    Filed: June 28, 2018
    Date of Patent: January 4, 2022
    Assignee: AICURIS GMBH & CO. KG
    Inventors: Yogeshwar Bachhav, Susanne Bonsmann, Tamara Pfaff, Alexander Birkmann, Karl Malcolm
  • NOVEL UREA 6,7-DIHYDRO-4H-PYRAZOLO[1,5-A]PYRAZINES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)
    Publication number: 20210355129
    Abstract: The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.
    Type: Application
    Filed: November 1, 2019
    Publication date: November 18, 2021
    Applicant: AICURIS GMBH & CO. KG
    Inventors: Alastair DONALD, Andreas URBAN, Susanne BONSMANN
  • NOVEL, HIGHLY ACTIVE PYRAZOLO-PIPERIDINE SUBSTITUTED INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)
    Publication number: 20210179608
    Abstract: The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.
    Type: Application
    Filed: November 2, 2018
    Publication date: June 17, 2021
    Applicant: AiCuris GmbH & Co. KG
    Inventors: Alastair DONALD, Andreas URBAN, Susanne BONSMANN, Anita WEGERT, Jasper SPRINGER
  • NOVEL, HIGHLY ACTIVE AMINO-THIAZOLE SUBSTITUTED INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)
    Publication number: 20200354379
    Abstract: The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.
    Type: Application
    Filed: November 2, 2018
    Publication date: November 12, 2020
    Applicant: AICURIS GMBH & CO. KG
    Inventors: Alastair DONALD, Andreas URBAN, Susanne BONSMANN, Anita WEGERT, Christiaan GREMMEN, Jasper SPRINGER
  • A MALEATE SALT OF THE FREE BASE OF N-[5-(AMINOSULFONYL)-4-METHYL-1.3-THIAZOL-2-YL]-N-METHYL-2-[4-(2-PYRIDINYL)-PHENYL]-ACETAMIDE, PHARMACEUTICAL FORMULATIONS, METHODS OF MANUFACTURE AND USES THEREOF FOR THE TREATMENT OF HERPES VIRUSES
    Publication number: 20200289485
    Abstract: The present invention relates to the field of anti-viral active agents, particularly to salts, more particularly to a maleate salt of the free base of N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)-phenyl]-acetamide, to pharmaceutical formulations thereof as well as to methods for the production of these salts. The present invention also relates to the use of theses salts and of respective pharmaceutical formulations thereof in methods of treatment and/or prevention of human herpes simplex virus infections, particulary infections caused by HSV-1 and HSV-2.
    Type: Application
    Filed: November 28, 2017
    Publication date: September 17, 2020
    Applicant: AICURIS ANTI-INFECTIVE CURES GMBH
    Inventors: Yogeshwar BACHHAV, Wilfried SCHWAB, Alexander BIRKMANN, Susanne BONSMANN, Thomas GOLDNER
  • INTRAVAGINALLY APPLICABLE DEVICES COMPRISING ANTIVIRAL COMPOUNDS
    Publication number: 20200121664
    Abstract: The present invention relates to field of intravaginally applicable devices that release antiviral compounds. In particular, the present invention relates to vaginal rings comprising a matrix releasing at least one antivirally active compound, in particular anti-herpetic compound N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl -N-methyl-2-[4-(2-pyridinyl)-phenyl]-acetamide (in the following also referred to as “Pritelivir”) or salts thereof. The present invention therefore relates to the treatment and prevention of herpes infections.
    Type: Application
    Filed: June 28, 2018
    Publication date: April 23, 2020
    Applicant: AICURIS ANTI-INFECTIVE CURES GMBH
    Inventors: Yogeshwar BACHHAV, Susanne BONSMANN, Tamara PFAFF, Alexander BIRKMANN, Karl MALCOLM
  • Novel formulations of amidine substituted beta-lactam compounds on the basis of modified cyclodextrins and acidifying agents, their preparation and use as antimicrobial pharmaceutical compositions
    Publication number: 20190365720
    Abstract: The present invention discloses novel formulations, reconstitutable solid compositions, pharmaceutical compositions, and aqueous injectable formulations of specific amidine substituted beta-lactam compounds on the basis of modified cyclodextrins and organic and/or inorganic acids, their preparation and use as antimicrobial pharmaceutical compositions that are parenterally or orally administrable.
    Type: Application
    Filed: November 17, 2017
    Publication date: December 5, 2019
    Applicant: AiCuris Anti-Infective Cures GmbH
    Inventors: Yogeshwar BACHHAV, Susanne BONSMANN, Tamara PFAFF