Patents by Inventor Susanne Grabley

Susanne Grabley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Furans and lactones from sterptomycetes and the use thereof
    Patent number: 5128370
    Abstract: New furans and lactones from streptomycetes, a process for the preparation thereof, and the use thereof.It is possible with the aid of various streptomycetes species to prepared new compounds having a furan or lactone structure. These compounds have a pharmacological, especially antibiotic, action.
    Type: Grant
    Filed: March 20, 1989
    Date of Patent: July 7, 1992
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Susanne Grabley, Joachim Wink, Klaus Kuhlein, Gerhard Seibert, Klaus Hutter, Hermann Uhr, Axel Zeeck
  • Streptenols from streptomycetes, and the preparation and use thereof
    Patent number: 5118882
    Abstract: Novel streptenols with pharmacological activity, in particular with HMG-CoA-reductase inhibiting activity, can be isolated from the nutrient broth of streptomycetes. These compounds can also be used as synthesis unit for the production of mevilonin analogues.
    Type: Grant
    Filed: February 22, 1990
    Date of Patent: June 2, 1992
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Axel Zeeck, Susanne Grabley, Joachim Wink, Peter Hammann, Carlo Giani, Pia Kricke-Helling
  • Angucyclinones from Streptomycetes, a process for the preparation thereof, and the use thereof
    Patent number: 5100921
    Abstract: New angucyclinones with a therapeutic action can be prepared with the aid of a strain of the genus Streptomyces.
    Type: Grant
    Filed: April 25, 1989
    Date of Patent: March 31, 1992
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Susanne Grabley, Joachim Wink, Carlo Giani, Gerhard Seibert, Wolfgang Raether, Susanne Dobreff, Axel Zeeck
  • 10-membered ring lactones, a process for the preparation thereof, and the use thereof
    Patent number: 5089521
    Abstract: New 10-membered ring lactones, a process for the preparation thereof, and the use thereof.It is possible with the aid of Penicillium strains to prepare new 10-membered ring lactones having a pharmacological action.
    Type: Grant
    Filed: August 3, 1990
    Date of Patent: February 18, 1992
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Joachim Wink, Susanne Grabley, Gerhard Seibert, Klaus Hutter, Axel Zeeck
  • Elaiophyline derivatives, compositions containing them and the use thereof as anthelmintic agents
    Patent number: 5011827
    Abstract: The invention relates to elaiophyline derivatives of the formula I ##STR1## in which R.sup.1 and R.sup.1' are identical or different and represent a radical of the formula II/or III ##STR2## in which R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.7 have the meanings given. The invention furthermore relates to a process for the preparation of these elaiophyline derivatives and also the use of the lattere as medicaments, in particular as anthelmintically acting medicaments.
    Type: Grant
    Filed: October 28, 1988
    Date of Patent: April 30, 1991
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Gerhard Kretzschmar, Dieter Duwel, Susanne Grabley, Peter Hammann, Gerhard Seibert, Hartmut Voelskow, Carlo Giani
  • Angucyclinones from streptomycetes, a process for the preparation thereof, and the use thereof
    Patent number: 4945108
    Abstract: New angucyclinones with a therapeutic action can be prepared with the aid of a strain of the genus Streptomyces.
    Type: Grant
    Filed: April 24, 1989
    Date of Patent: July 31, 1990
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Susanne Grabley, Joachim Wink, Carlo Giani, Gerhard Seibert, Wolfgang Raether, Susanne Dobreff, Axel Zeeck
  • Amycin and its derivatives, a process for their preparation, and their use
    Patent number: 4914216
    Abstract: Streptomyces parvullus, DSM 3816, produces on aerobic fermentation new antibiotics which are distinguished by antimicrobial activity even after derivatization.
    Type: Grant
    Filed: December 22, 1987
    Date of Patent: April 3, 1990
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Peter Hammann, Susanne Grabley, Hartmut Voelskow, Burkhard Sachse, Wolfgang Raether, Carlo Giani, Gerhard Seibert
  • Process for the preparation of the demalonyl compound of macrolide lactones
    Patent number: 4873347
    Abstract: It is possible to prepare the demalonyl compound of macrolide lactones by hydrolysis in the presence of a base without a retro-aldol cleavage occurring.
    Type: Grant
    Filed: December 22, 1987
    Date of Patent: October 10, 1989
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Peter Hammann, Susanne Grabley, Wolfgang Raether, Bernd Ciommer, Heinz Kluge, Burkhard Sachse
  • Gentisic acid derivatives having antibiotic activity
    Patent number: 4861796
    Abstract: 2-Acetylaminogentisic acid has been isolated from the culture broth after cultivation of a bacterium of the genus Streptomyces. This compound has antibacterial actions against Gram-positive and Gram-negative bacteria.
    Type: Grant
    Filed: December 19, 1988
    Date of Patent: August 29, 1989
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Axel Zeeck, Sabine Breiding-Mack, Susanne Grabley, Hartmut Voelskow, Gerhard Seibert
  • Pharmacological use of phenoxazinones
    Patent number: 4861775
    Abstract: Streptomyces spec. DSM 3813 produces novel compounds with a basic phenoxazinone structure, which have an antifungal and antiviral action and can be used as lipoxygenase inhibitors.
    Type: Grant
    Filed: August 25, 1987
    Date of Patent: August 29, 1989
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Axel Zeeck, Sabine Breiding-Mack, Susanne Grabley, Hartmut Voelskow, Gerhard Seibert
  • Diels-alder adduct from streptazoline and naphthoquinones and its oxidation products, which have cytotoxic and antimicrobial activity and which act against protozoa
    Patent number: 4849409
    Abstract: Streptazoline is reacted with naphthoquinones in a Diels-Alder reaction, and the adduct is then oxidized. The resulting compounds have cytotoxic activity, in particular against leukemia cells, and have an antimicrobial action and act against protozoa.
    Type: Grant
    Filed: May 12, 1987
    Date of Patent: July 18, 1989
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Hans-Ullrich Hoppe, Susanne Grabley, Hartmut Voelskow, Merten Schlingmann, Hans P. Kraemer, Matthias Wiesner, Joachim Thiem
  • Process for the racemization of optically active aminoacids
    Patent number: 4638086
    Abstract: The racemization of optically active aminoacids (including their N-acyl derivatives) by heating with carboxylic acids takes place particularly readily with carboxylic acids of low volatility. Only catalytic quantities of acid are needed; it is advantageous to use equimolar quantities or an excess, which serves as a diluent. A reaction mixture from an enzymatic racemate resolution can be heated directly for the purpose of racemization, after separation of the L-aminoacid and the water.
    Type: Grant
    Filed: September 25, 1984
    Date of Patent: January 20, 1987
    Assignee: Hoechst Aktiengesellschaft
    Inventor: Susanne Grabley
  • Process for the enzymatic preparation of L-2-amino-4-methylphosphinobutyric acid
    Patent number: 4389488
    Abstract: A process for the enzymatic preparation of L-2-amino-4-methylphosphinobutyric acid by enzymatic cleavage of the corresponding N-arylacetyl derivatives using penicillin-G-acylase.
    Type: Grant
    Filed: December 21, 1981
    Date of Patent: June 21, 1983
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Susanne Grabley, Klaus Sauber