Patents by Inventor Susanne Klumpp

Susanne Klumpp has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of protein histidine phosphatase
    Publication number: 20060153825
    Abstract: The invention relates to the use of polypeptides with protein histidine phosphatase activity derived from mammalians, antibodies directed against them and DNA or RNA sequences complementary to mRNA sequences encoding polypeptides with protein histidine phosphatase activity for the modulation of ATP-citrate lyase and treatment of correlated pathophysiologic functions.
    Type: Application
    Filed: March 4, 2002
    Publication date: July 13, 2006
    Applicant: Merck Patent GmbH
    Inventors: Roland Kellner, Susanne Klumpp
  • Substrate for PP2C
    Patent number: 6933127
    Abstract: The invention relates to a combination of a protein phosphatase type 2C as an enzyme and a phospho-BAD as substrate. The protein BAD is dephosphorylated in position Ser155. Furthermore, the combination is used in an in vitro screening for ligands which modulate protein phosphatase type 2C, comprising the steps: incubating the protein phosphatase type 2C in combination with the substrate phospho-BAD and the ligand of the assay and detecting the decrease in phospho-BAD and/or the increase in phosphate and/or BAD. Therefore, new drugs for the treatment apoptosis may be found.
    Type: Grant
    Filed: July 3, 2002
    Date of Patent: August 23, 2005
    Assignee: EUCRO European Contract Research GmbH & Co. KG
    Inventors: Josef Krieglstein, Susanne Klumpp
  • Histidine protein-phosphatase
    Patent number: 6812015
    Abstract: The invention relates to a novel enzyme, histidine protein phosphatase, which is derived from mammalian sources, and its homologue variants. The invention further relates to DNA sequences encoding said proteins, to a process for preparing the latter, and to antibodies directed against them. The novel phosphatase can be used for diagnosis of pathological states of cell regulation and cell growth and as pharmaceutical drug which can be administered in conjunction with pathological disorders related to malfunctions of said enzyme.
    Type: Grant
    Filed: September 4, 2001
    Date of Patent: November 2, 2004
    Assignee: Merck Patent Gesellschaft
    Inventors: Susanne Klumpp, Roland Kellner
  • Method for the treatment of arteriosclerosis
    Publication number: 20040086495
    Abstract: The invention refers to a method for the prevention of arteriosclerosis or the reduction of the arteriosclerosis risk, by purposefully effecting the phosphorylation status of BAD.
    Type: Application
    Filed: July 5, 2002
    Publication date: May 6, 2004
    Applicant: EUCRO EUROPEAN CONTRACT RESEARCH GMBH & CO. KG
    Inventors: Josef Kriegelstein, Susanne Klumpp
  • Substrate for PP2C
    Publication number: 20030044875
    Abstract: The invention relates to a combination of a protein phosphatase type 2C as an enzyme and a phospho-BAD as substrate. The protein BAD is dephosphorylated in position Ser155. Furthermore, the combination is used in an in vitro screening for ligands which modulate protein phosphatase type 2C, comprising the steps: incubating the protein phosphatase type 2C in combination with the substrate phospho-BAD and the ligand of the assay and detecting the decrease in phospho-BAD and/or the increase in phosphate and/or BAD. Therefore, new drugs for the treatment apoptosis may be found.
    Type: Application
    Filed: July 3, 2002
    Publication date: March 6, 2003
    Applicant: Schering AG
    Inventors: Josef Krieglstein, Susanne Klumpp