Patents by Inventor Susanne M. Brown

Susanne M. Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment of Non-Neuronal Cancer using HSV-1 Variants
    Publication number: 20110195053
    Abstract: A mutant herpes simplex virus which has been modified in the ?34.5 gene such that the gene is non-functional is used to treat a non-neuronal cancer such as a mesothelioma, ovarian carcinoma, bladder cancer or melanoma. Typically, the mutant herpes simplex virus has been modified within the BamHI restriction fragment of the long terminal repeat of the viral genome.
    Type: Application
    Filed: April 20, 2011
    Publication date: August 11, 2011
    Applicants: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, CRUSADE LABORATORIES LIMITED, WISTAR INSTITUTE
    Inventors: Susanne M. Brown, Alasdair R. Maclean, Nigel W. Fraser, Bruce P. Randazzo, Steven Albelda, Larry Kaiser, John Kucharczuk
  • Methods for identifying cell cycle regulators
    Patent number: 6641995
    Abstract: A method is disclosed for identifying a substance capable of disrupting an interaction between (i) a herpes simplex virus (HSV) ICP34.5 polypeptide or a homologue thereof, or a derivative thereof, and (ii) proliferating cell nuclear antigen (PCNA) or a homologue thereof, or a derivative thereof, which method comprises: (a) providing an HSV ICP34.5 polypeptide or a homologue thereof, or a derivative thereof, as a first component; (b) providing PCNA, or a homologue thereof, or a derivative thereof, as a second component; (c) contacting the two components with a substance to be tested under conditions that would permit the two components to interact in the absence of the said substance; and (d) determining whether the said substance disrupts the interaction between the first and second components.
    Type: Grant
    Filed: December 29, 2000
    Date of Patent: November 4, 2003
    Assignee: The University Court of the University of Glasgow
    Inventors: Susanne M. Brown, Alasdair R. Maclean, June Harland
  • Herpes simplex virus-1 deletion variants and vaccines thereof
    Patent number: 6423528
    Abstract: Novel Herpes simplex viruses and vaccines based on such novel HSV-1 strains are described. In particular, viruses having a deletion in the terminal portion of RL are provided. The virus can be further modified to express heterologous antigens and also engineered to overproduce HSV Light particles. This is achieved by incorporating a ts mutation into the UL26 gene.
    Type: Grant
    Filed: June 16, 1999
    Date of Patent: July 23, 2002
    Assignee: The University Court of the University of Glasgow
    Inventors: Susanne M. Brown, Alasdair R. MacLean
  • Methods for identifying cell cycle regulators
    Patent number: 6235467
    Abstract: The present invention relates to a method for identifying a substance capable of disrupting an interaction between (i) a herpes simplex virus (HSV) ICP34.5 polypeptide or a homologue thereof, or a derivative thereof, and (ii) proliferating cell nuclear antigen (PCNA) or a homologue thereof, or a derivative thereof. The method comprises: (a) providing an HSV ICP34.5 polypeptide or a homologue thereof, or a derivative thereof, as a first component; (b) providing PCNA, or a homologue thereof, or a derivative thereof, as a second component; (c) contacting the two components with a substance to be tested under conditions that would permit the two components to interact in the absence of the substance; and (d) determining whether the substance disrupts the interaction between the first and second components.
    Type: Grant
    Filed: November 29, 1999
    Date of Patent: May 22, 2001
    Assignees: Medical Research Council, The University Court of the University of Glasgow
    Inventors: Susanne M. Brown, Alasdair R. Maclean, June Harland
  • Methods for identifying cell cycle regulators
    Publication number: 20010001058
    Abstract: A methods is disclosed for identifying a substance capable of disrupting an interaction between (i) a herpes simplex virus (HSV) ICP34.5 polypeptide or a homologue thereof, or a derivative thereof, and (ii) proliferating cell nuclear antigen (PCNA) or a homologue thereof, or a derivative thereof, which method comprises: (a) providing an HSV ICP34.5 polypeptide or a homologue thereof, or a derivative thereof, as a first component; (b) providing PCNA, or a homologue thereof, or a derivative thereof, as a second component; (c) contacting the two components with a substance to be tested under conditions that would permit the two components to interact in the absence of the said substance; and (d) determining whether the said substance disrupts the interaction between the first and second components.
    Type: Application
    Filed: December 29, 2000
    Publication date: May 10, 2001
    Applicant: MEDICAL RESEARCH COUNCIL AND THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW
    Inventors: Susanne M. Brown, Alasdair R. Maclean, June Harland