Patents by Inventor Susanne Moira Brown

Susanne Moira Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Herpes simplex viruses and methods of viral replication
    Patent number: 8969063
    Abstract: A herpes simplex virus is disclosed in which the herpes simplex virus genome comprises a nucleic acid sequence encoding an ING4 polypeptide.
    Type: Grant
    Filed: March 12, 2012
    Date of Patent: March 3, 2015
    Assignee: Virttu Biologics Limited
    Inventors: Joe Conner, Susanne Moira Brown
  • Herpes simplex virus complex
    Patent number: 8778684
    Abstract: There is provided an HSV complex which comprises an avirulent HSV and a targeting agent which allows the HSV particle to infect and lyse a specific targeted cell. The inventors have found a way in which avirulent HSV can be targeted to disease cells, e.g. cancer cells, by incorporating an antibody binding domain into one or more viral glycoproteins.
    Type: Grant
    Filed: April 13, 2011
    Date of Patent: July 15, 2014
    Assignee: Virttu Biologics Limited
    Inventors: Susanne Moira Brown, Joe Conner
  • Methods for treating cancer using herpes simplex virus expressing antisense to the squamous cell carcinoma related oncogene
    Patent number: 8530437
    Abstract: An herpes simplex virus wherein the herpes simplex virus genome comprises nucleic acid encoding an antisense to the squamous cell carcinoma related oncogene (asSCCRO); and an herpes simplex virus wherein the herpes simplex virus genome comprises nucleic acid encoding a short interfering ribonucleic acid (siRNA) molecule that is capable of repressing or silencing expression of squamous cell carcinoma related oncogene (SCCRO) nucleic acid or polypeptide are disclosed together with methods for generation and applications of such viruses.
    Type: Grant
    Filed: May 6, 2009
    Date of Patent: September 10, 2013
    Assignees: Sloan Kettering Institute for Cancer Research, Virttu Biologics Limited
    Inventors: Susanne Moira Brown, Paul Dunn, Bhuvanesh Singh, Ian Ganly
  • HERPES SIMPLEX VIRUSES AND METHODS OF VIRAL REPLICATION
    Publication number: 20120237999
    Abstract: A herpes simplex virus is disclosed in which the herpes simplex virus genome comprises a nucleic acid sequence encoding an ING4 polypeptide.
    Type: Application
    Filed: March 12, 2012
    Publication date: September 20, 2012
    Applicant: VIRTTU BIOLOGICS LIMITED
    Inventors: Joe Conner, Susanne Moira Brown
  • Treatment of Melanoma Using HSV Mutant
    Publication number: 20120141418
    Abstract: Use as an anti-cancer agent of a mutant herpes simplex virus wherein the mutant virus comprises a modification in the ?34.5 gene in the long repeat region (RL) such that the ?34.5 gene is a non-functional, manufacture of medicaments and methods of testing cancer in mammals employing HSV mutant.
    Type: Application
    Filed: November 28, 2011
    Publication date: June 7, 2012
    Applicants: THE WISTAR INSTITUTE, Virttu Biologics Limited
    Inventors: Alasdair Roderick MacLean, Susanne Moira Brown, Nigel William Fraser, Bruce Paul Randazzo
  • Herpes simplex viruses and methods of viral replication
    Patent number: 8163292
    Abstract: A herpes simplex virus is disclosed in which the herpes simplex virus genome comprises a nucleic acid sequence encoding an ING4 polypeptide.
    Type: Grant
    Filed: February 15, 2008
    Date of Patent: April 24, 2012
    Assignee: Virttu Biologics Limited
    Inventors: Joe Conner, Susanne Moira Brown
  • Treatment of melanoma using HSV mutant
    Patent number: 8067012
    Abstract: Use as an anti-cancer agent of a mutant herpes simplex virus wherein the mutant virus comprises a modification in the ?34.5 gene in the long repeat region (RL) such that the ?34.5 gene is a non-functional, manufacture of medicaments and methods of testing cancer in mammals employing HSV mutant.
    Type: Grant
    Filed: January 22, 2010
    Date of Patent: November 29, 2011
    Assignees: Crusade Laboratories Limited, The Wistar Institute
    Inventors: Alasdair Roderick MacLean, Susanne Moira Brown, Nigel William Fraser, Bruce Paul Randazzo
  • Herpes Simplex Virus Complex
    Publication number: 20110244576
    Abstract: There is provided an HSV complex which comprises an avirulent HSV and a targeting agent which allows the HSV particle to infect and lyse a specific targeted cell. The inventors have found a way in which avirulent HSV can be targeted to disease cells, e.g. cancer cells, by incorporating an antibody binding domain into one or more viral glycoproteins.
    Type: Application
    Filed: April 13, 2011
    Publication date: October 6, 2011
    Applicant: CRUSADE LABORATORIES LIMITED
    Inventors: Susanne Moira Brown, Joe Conner
  • Treatment Using Herpes Simplex Virus
    Publication number: 20110158948
    Abstract: Herpes Simplex Viruses are disclosed having single-chain antibodies (scFv) embedded in the viral envelope via fusion with glycoprotein D and with glycoprotein H and L.
    Type: Application
    Filed: January 12, 2011
    Publication date: June 30, 2011
    Applicant: CRUSADE LABORATORIES LIMITED
    Inventors: Susanne Moira Brown, Guy Michael Gary Hamilton
  • Herpes simplex virus complex
    Patent number: 7943144
    Abstract: There is provided an HSV Complex which comprises an avirulent HSV and a targeting agent which allows the HSV particle to infect and lyse a specific targeted cell. The inventors have found a way in which avirulent HSV can be targeted to disease cells, e.g. cancer cells, by incorporating an antibody binding domain into one or more viral glycoproteins.
    Type: Grant
    Filed: February 12, 2003
    Date of Patent: May 17, 2011
    Assignee: Crusade Laboratories Limited
    Inventors: Susanne Moira Brown, Joe Conner
  • Treatment using herpes simplex virus
    Patent number: 7897146
    Abstract: The use of Herpes Simplex Virus (HSV) in the treatment of tumour by extratumoural administration of HSV, and the use of HSV in treatment of tumour by combination therapy with a pharmaceutical wherein the HSV and/or pharmaceutical is administered at an extratumoural location, is disclosed.
    Type: Grant
    Filed: August 30, 2006
    Date of Patent: March 1, 2011
    Assignee: Crusade Laboratories Limited
    Inventors: Susanne Moira Brown, Guy Michael Gary Hamilton
  • Treatment of Cancer Using HSV Mutant
    Publication number: 20100172872
    Abstract: Use as an anti-cancer agent of a mutant herpes simplex virus wherein the mutant virus comprises a modification in the ?34.5 gene in the long repeat region (RL) such that the ?34.5 gene is a non-functional, manufacture of medicaments and methods of testing cancer in mammals employing HSV mutant.
    Type: Application
    Filed: January 22, 2010
    Publication date: July 8, 2010
    Applicants: CRUSADE LABORATORIES LIMITED, THE WISTAR INSTITUTE
    Inventors: Alasdair Roderick MacLean, Susanne Moira Brown, Nigel William Fraser, Bruce Paul Randazzo
  • HERPES SIMPLEX VIRUSES AND METHODS OF VIRAL REPLICATION
    Publication number: 20100092515
    Abstract: A herpes simplex virus is disclosed in which the herpes simplex virus genome comprises a nucleic acid sequence encoding an ING4 polypeptide.
    Type: Application
    Filed: February 15, 2008
    Publication date: April 15, 2010
    Applicant: CRUSADE LABORATORIES LIMITED
    Inventors: Joe Conner, Susanne Moira Brown
  • Treatment of cancer using HSV mutant
    Patent number: 7674468
    Abstract: Use as an anti-cancer agent of a mutant herpes simplex virus wherein the mutant virus comprises a modification in the ?34.5 gene in the long repeat region (RL) such that the ?34.5 gene is a non-functional, manufacture of medicaments and methods of testing cancer in mammals employing HSV mutant.
    Type: Grant
    Filed: June 13, 2005
    Date of Patent: March 9, 2010
    Assignees: Crusade Laboratories Limited, The Wistar Institute
    Inventors: Alasdair Roderick MacLean, Susanne Moira Brown, Nigel William Fraser, Bruce Paul Randazzo
  • Mutant Viruses
    Publication number: 20090274728
    Abstract: An herpes simplex virus wherein the herpes simplex virus genome comprises nucleic acid encoding an antisense to the squamous cell carcinoma related oncogene (asSCCRO); and an herpes simplex virus wherein the herpes simplex virus genome comprises nucleic acid encoding a short interfering ribonucleic acid (siRNA) molecule that is capable of repressing or silencing expression of squamous cell carcinoma related oncogene (SCCRO) nucleic acid or polypeptide are disclosed together with methods for generation and applications of such viruses.
    Type: Application
    Filed: May 6, 2009
    Publication date: November 5, 2009
    Applicants: CRUSADE LABORATORIES LIMITED, SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH
    Inventors: Susanne Moira Brown, Bhuvanesh Singh, Ian Ganly, Paul Dunn
  • Mutant Herpes Simplex Viruses Comprising Nucleic Acid Encoding A Nitroreductase
    Publication number: 20090208460
    Abstract: An herpes simplex virus wherein the herpes simplex virus genome comprises nucleic acid encoding a nitroreductase (NTR) is disclosed. Disclosed herpes simplex viruses are indicated to be useful in the treatment of cancer which may involve gene directed enzyme prodrug therapy.
    Type: Application
    Filed: January 21, 2009
    Publication date: August 20, 2009
    Applicant: CRUSADE LABORATORIES LIMITED
    Inventors: Susanne Moira Brown, Paul Dunn
  • Mutant herpes simplex viruses comprising nucleic acid encoding a nitroreductase
    Patent number: 7498161
    Abstract: An herpes simplex virus wherein the herpes simplex virus genome comprises nucleic acid encoding a nitroreductase (NTR) is disclosed. Disclosed herpes simplex viruses are indicated to be useful in the treatment of cancer which may involve gene directed enzyme prodrug therapy.
    Type: Grant
    Filed: November 17, 2004
    Date of Patent: March 3, 2009
    Assignee: Crusade Laboratories Limited
    Inventors: Susanne Moira Brown, Paul Dunn
  • Treatment Using Herpes Simplex Virus
    Publication number: 20090010889
    Abstract: The use of Herpes Simplex Virus (HSV) in the treatment of tumour by extratumoural administration of said HSV, and the use of HSV in treatment of tumour by combination therapy with a pharmaceutical wherein the HSV and/or pharmaceutical is administered at an extratumoural location, is disclosed.
    Type: Application
    Filed: August 30, 2006
    Publication date: January 8, 2009
    Applicant: CRUSADE LABORATORIES LIMITED
    Inventors: Susanne Moira Brown, Guy Michael Gary Hamilton
  • Recombinant equine herpesvirus type 1 (EHV-1) comprising a dysfunctional gene 71 region and use thereof as a vaccine
    Publication number: 20020155131
    Abstract: Vaccine formulation comprising EHV-1 gene 71 dysfunctional mutant and uses thereof.
    Type: Application
    Filed: October 19, 2001
    Publication date: October 24, 2002
    Applicant: University Court of The University of Glasgow
    Inventors: Susanne Moira Brown, Yi Sun, Hugh John Field
  • Herpes simplex virus-1 deletion variants and vaccines thereof
    Patent number: 6040169
    Abstract: Novel Herpes simplex viruses and vaccines based on such novel HSV-1 strains are described. In particular, viruses having a deletion in the terminal portion of R.sub.L are provided. The virus can be further modified to express heterologous antigens and also engineered to overproduce HSV Light particles. This is achieved by incorporating a ts mutation into the UL26 gene.
    Type: Grant
    Filed: December 13, 1996
    Date of Patent: March 21, 2000
    Assignee: Medical Research Council
    Inventors: Susanne Moira Brown, Alasdair Roderick MacLean