Abstract: The invention relates to methods for synthesizing amanitin derivatives having an amino group attached to position 6? of the central tryptophan moiety. The invention furthermore relates to an amanitin derivative having an amino group attached to position 6? of the central tryptophan moiety, conjugates of such amanitin derivative, and pharmaceutical compositions comprising such conjugates.

Abstract: An alkoxylated polyamidoamine obtainable by a) reacting a polycarboxylic compound having a total number TN of carboxylic groups of 3 to 10 with a primary diamine of formula I H2N—Z—NH2 wherein Z represents a bond or an organic group with 1 to 20 carbon atoms in a ratio of 0.3 TN to TN mols of the diamine per 1 mol of the polycarboxylic compound and b) alkoxylating the product obtained in a) with at least 0.5 mol of alkyleneoxide per 1 mol of primary amino groups.

Abstract: A wrought alloy for a bearing material for use as valve guide or in turbochargers of internal-combustion engines operated with ethanol-containing fuels The composition of the wrought alloy is as follows in wt%: Zn: 25.0 - 34.0%; Fe: 0.8 - 1.2%; Sn: 0.8 - 1.2%; Al: 1.3 -1.7%; Si: 0.2 - 0.45%; and Pb: up to 0.1%, with the balance being copper and unavoidable impurities The sum total of all elements not belonging to the group of the elements copper, zinc, iron, tin, aluminum and silicon is at most 0.3 wt%. The alloy has a microstructure including precipitates in the form of silicides with a fraction of 0.5 to 2.0 vol%.

Abstract: A method for electrically conductively contacting an optoelectronic component having at least one protective layer, including: providing the optoelectronic component having the at least one protective layer with at least one busbar arranged below the at least one protective layer, forming at least one opening by at least one laser beam in the at least one protective layer, wherein at least one busbar arranged below the at least one protective layer is partly exposed, such that the at least one busbar is not damaged, introducing a low-melting solder into the at least one opening of the at least one protective layer, aligning and fixing an electrically conductive element that is flexible on a side of the at least one opening opposite the at least one busbar, and forming an electrically conductive connection element in the at least one opening.

Abstract: The use of HMG box-binding molecules and molecules having sequence homology with HMG box for the preparation of therapeutic agents for the treatment of vascular diseases is described.

Abstract: A method of treating vascular diseases by administering an antagonist molecule that inhibits the interaction between a protein of the HMG box family and a receptor for the protein of the HMG box family.

Abstract: The use of HMG box-binding molecules and molecules having sequence homology with HMG box for the preparation of therapeutic agents for the treatment of vascular diseases is described.

Abstract: A method of inhibiting atherosclerosis by administering a molecule that binds a protein of the HMG box family. Also, a method of treating vascular diseases by administering an antagonist molecule to inhibit the interaction between a protein of the HMG box family and a receptor for the protein of the HMG box family.

Abstract: The use of HMG box-binding molecules and molecules having sequence homology with HMG box for the preparation of therapeutic agents for the treatment of vascular diseases is described

Abstract: The use of HMG box-binding molecules and molecules having sequence homology with HMG box for the reparation of therapeutic agents for the treatment of vascular diseases is described.

Abstract: Absorbent articles such as diapers, incontinent briefs, training pants, diaper holders and liners, feminine hygiene garments, and the like, designed to provide sustained dynamic fit about the wearer during use as well as to improve the containment of body exudates and wearer comfort/mobility. Such an absorbent article has an absorbent core preferably designed to fit within the low motion zone of the wearer so that dynamic forces imparted by movements of the wearer on the absorbent core are minimized. The absorbent article is also provided with a closure system for anchoring the absorbent article on the wearer to sustain the dynamic fit of the absorbent article throughout wearing. The closure system is designed so that a primary line of tension, fitting at an angle to the body, is formed to secure the absorbent article on a wearer.

Abstract: Absorbent articles such as diapers, incontinent briefs, training pants, diaper holders and liners, feminine hygiene garments, and the like, designed to provide sustained dynamic fit about the wearer during use as well as to improve the containment of body exudates and wearer comfort/mobility. Such an absorbent article has an absorbent core preferably designed to fit within the low motion zone of the wearer so that dynamic forces imparted by movements of the wearer on the absorbent core are minimized. The absorbent article is also provided with a closure system for anchoring the absorbent article on the wearer to sustain the dynamic fit of the absorbent article throughout wearing. The closure system is designed so that a primary line of tension, fitting at an angle to the body, is formed to secure the absorbent article on a wearer.