Publication number: 20170334917
Abstract: The present application relates to novel substituted piperidinylpyrazolopyrimidinones, to processes for their preparation, the compounds for use alone or in combinations in a method for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of acute and recurrent bleeding in patients with or without underlying hereditary or acquired hemostatic disorders, wherein the bleeding is associated with a disease or medical intervention selected from the group consisting of heavy menstrual bleeding, postpartum hemorrhage, hemorrhagic shock, hemorrhagic cystitis, gastrointestinal hemorrhage, trauma, surgery, transplantation, stroke, liver diseases, hereditary angioedema, nosebleed, and synovitis and cartilage damage following hemarthrosis.
Type:
Application
Filed:
October 30, 2015
Publication date:
November 23, 2017
Applicant:
BAYER PHARMA AKTIENGESELLSCHAFT
Inventors:
Manuel ELLERMANN, Gaelle VALOT, Yolanda CANCHO GRANDE, Jorma HAßFELD, Tom KINZEL, Johannes KÖBBERLING, Kristin BEYER, Susanne RÖHRIG, Michael SPERZEL, Jan STAMPFUß, Imke MEYER, Maria KÖLLNBERGER, Nils BURKHARDT, Karl-Heinz SCHLEMMER, Christian STEGMANN, Joachim SCHUHMACHER, Matthias WERNER, Jörg HEIERMANN, Willem Jan HENGEVELD