Abstract: The invention relates to compounds useful as inhibitors of NO production, especially inhibitors of the inducible NO synthase iNOS expressed by microglia and macrophages. The invention also relates to pharmaceutical compositions comprising these compounds and to therapeutic uses of these compounds, especially in the prophylaxis or treatment of conditions characterized by excess NO production, such as ischemic stroke and retinopathies.

Abstract: A method for quantitative determination of bioavailable L-tryptophan in faeces and a method of diagnosis whether a subject is suffering from impaired fructose absorption or from a lack of bioavailable tryptophan. The latter includes the localization of a previously hidden aetiology of decreased blood tryptophan levels and a method of in vitro diagnosis of the aetiology of gastrointestinal (IBD), Crohn's disease, depression symptoms, anxiety, insomnia, sleep disorders, dysphoric disorders. A kit of parts for determining the ratio of free L-tryptophan to blocked glycated tryptophan or fructosyl-tryptophan adduct for immediate treatment of these disorders by providingpatients with appropriate dietary recommendations or an intake of tryptophan that is not blocked or glycated in the acidic environment of the stomach or gastrointestinal tract.

Abstract: A directionally flexible shank for an article of footwear is disclosed, which provides support to the bottom of a user's foot while providing flexibility for foot movements in one or more particular directions. The directionally flexible shank may also support the arch of the foot. The directionally flexible shank may include a plurality of articulatable segments that can easily rotate with respect to each other in a first direction and thereby permit the directionally flexible shank to flex away from the foot, while limiting articulation in an opposite direction. The articulatable segments are connected to each other via hinge structures, which may include living hinges formed of a thermoplastic material. The hinge structures may also be formed from a flexible sheet attached to a bottom portion of the directionally flexible shank. Methods are also disclosed for manufacturing the directionally flexible shank.

Abstract: A directionally flexible shank for an article of footwear is disclosed, which provides support to the bottom of a user's foot while providing flexibility for foot movements in one or more particular directions. The directionally flexible shank may also support the arch of the foot. The directionally flexible shank may include a plurality of articulatable segments that can easily rotate with respect to each other in a first direction and thereby permit the directionally flexible shank to flex away from the foot, while limiting articulation in an opposite direction. The articulatable segments are connected to each other via hinge structures, which may include living hinges formed of a thermoplastic material. The hinge structures may also be formed from a flexible sheet attached to a bottom portion of the directionally flexible shank. Methods are also disclosed for manufacturing the directionally flexible shank.

Abstract: An article of footwear is disclosed that includes an upper and a sole structure secured to the upper. The sole structure may include a flexible arch support adapted to provide support for a user's arch while permitting the arch to flex away from the user's foot. The flexible arch support may include a plurality of articulatable segments that, from a resting position, can rotate with respect to each other away from the user's foot, while resisting articulation in an opposite direction. The upper may include articulatable straps that secure the article of footwear to the user's foot while providing flexibility for foot bends or other movements.

Abstract: An article of footwear and a method of manufacturing the footwear are disclosed. The footwear has an upper and a sole structure. The upper is secured to sole structure and the upper is formed from three layers: a first layer, a second layer, and a third layer. The second layer is formed from a polymer material and molded to the first layer, but the second layer may alternately be molded to the third layer. The third layer is joined with at least one of the first layer and the second layer such that the second layer is positioned between the first layer and the third layer.

Abstract: An article of footwear is disclosed that includes an upper and a sole structure secured to the upper. The sole structure has a midsole element that defines a void, and the void may extend substantially vertically through a central area of the midsole element. The void may also extend between an upper surface and a lower surface of the midsole element to define an interior surface. A plurality of bores are also defined in the midsole element. The bores may extend substantially horizontally through the midsole element, and the bores may extend between an exterior surface of the midsole element and the void.

Abstract: An article of footwear is disclosed that includes an upper and a sole structure secured to the upper. The sole structure has a midsole element that defines a void, and the void may extend substantially vertically through a central area of the midsole element. The void may also extend between an upper surface and a lower surface of the midsole element to define an interior surface. A plurality of bores are also defined in the midsole element. The bores may extend substantially horizontally through the midsole element, and the bores may extend between an exterior surface of the midsole element and the void.

Abstract: An article of footwear is disclosed that includes an upper and a sole structure secured to the upper. The sole structure may include a flexible arch support adapted to provide support for a user's arch while permitting the arch to flex away from the user's foot. The flexible arch support may include a plurality of articulatable segments that, from a resting position, can rotate with respect to each other away from the user's foot, while resisting articulation in an opposite direction. The upper may include articulatable straps that secure the article of footwear to the user's foot while providing flexibility for foot bends or other movements.

Abstract: A directionally flexible shank for an article of footwear is disclosed, which provides support to the bottom of a user's foot while providing flexibility for foot movements in one or more particular directions. The directionally flexible shank may also support the arch of the foot. The directionally flexible shank may include a plurality of articulatable segments that can easily rotate with respect to each other in a first direction and thereby permit the directionally flexible shank to flex away from the foot, while limiting articulation in an opposite direction. The articulatable segments are connected to each other via hinge structures, which may include living hinges formed of a thermoplastic material. The hinge structures may also be formed from a flexible sheet attached to a bottom portion of the directionally flexible shank. Methods are also disclosed for manufacturing the directionally flexible shank.

Abstract: Articles of footwear include a textile upper member with an exterior constructed from knitted textile material, the exterior including a region with stability ribs and a second unribbed region. The region(s) having stability ribs may be located, for example: along a lateral midfoot side of the upper member; along a forefoot portion of the upper member; and/or along a medial midfoot side of the upper member. Other articles of footwear include an upper member having exterior and interior textile elements joined together in a stitchless manner at the foot-receiving opening of the upper member. The exterior surface of this upper member also may include one or more regions with stability structures. The stitchless textile engagement techniques can provide a smooth, non-bulky, and breathable joint that does not require thick layers of textile material in contact with or adjacent the wearer's foot.

Abstract: An article of footwear includes a sole with a midsole. A midsole plate includes a lateral fork member and a medial fork member configured to provide flexibility to the phalanges bones during ground engaging actions. The midsole plate includes a plurality of perforations configured for air communication within an upper of an article of footwear. A midsole plate may include a phalanx portion, a metatarsal portion and a midfoot portion corresponding to a foot of a wearer. The phalanx portion, the metatarsal portion, and the midfoot portion each have a different stiffness with respect to each other.

Abstract: An article of footwear and a method of manufacturing the footwear are disclosed. The footwear has an upper and a sole structure. The upper is secured to sole structure and the upper is formed from three layers: a first layer, a second layer, and a third layer. The second layer is formed from a polymer material and molded to the first layer, but the second layer may alternately be molded to the third layer. The third layer is joined with at least one of the first layer and the second layer such that the second layer is positioned between the first layer and the third layer.

Abstract: An article of footwear is disclosed that includes an upper and a sole structure secured to the upper. The sole structure has a midsole element that defines a void, and the void may extend substantially vertically through a central area of the midsole element. The void may also extend between an upper surface and a lower surface of the midsole element to define an interior surface. A plurality of bores are also defined in the midsole element. The bores may extend substantially horizontally through the midsole element, and the bores may extend between an exterior surface of the midsole element and the void.