Patents by Inventor Susanta Sekhar Adhikari

Susanta Sekhar Adhikari has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tryptamine derivatives, their preparation and their use in gastropathy
    Patent number: 8901317
    Abstract: The synthesis and evaluation of gastroprotective effect of different tryptamine derivatives. Tryptamine derivatives have been synthesized by formation of amide or ester with some known anti oxidant molecules. These derivatives show excellent antioxidant property in vitro. Among all the derivatives the compound SEGA (3a), that was prepared by the combination of serotonin with gallic acid shows the greater antioxidant property than the other synthesized compounds both in vivo and in vitro. SEGA(3a) shows the gastroprotective effect against NSAIDs (indomethacin or diclofenac)-induced gastropathy in dose dependent manner and also accelerates the healing from injury. It prevents the NSAIDs-induced mitochondrial oxidative stress in vivo. This derivative prevents NSAID-induced mitochondrial oxidative stress-mediated apoptosis in vivo by preventing the activation of caspase 9 and caspase-3 and restores NSAIDs-mediated collapse of mitochondroial transmembrane potential and dehydrogenase activity.
    Type: Grant
    Filed: September 14, 2011
    Date of Patent: December 2, 2014
    Assignees: Council of Scientific & Industrial Research, University of Calcutta
    Inventors: Uday Bandyopadhyay, Chinmay Pal, Samik Bindu, Susanta Sekhar Adhikari
  • Antibacterial 4,5-substituted aminoglycoside analogs having multiple substituents
    Patent number: 8569264
    Abstract: The present invention is directed to analogs of aminoglycoside compounds as well as their preparation and use as prophylactic or therapeutics against microbial infection.
    Type: Grant
    Filed: January 5, 2012
    Date of Patent: October 29, 2013
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Eric E. Swayze, Stephen Hanessian, Janek Szychowski, Susanta Sekhar Adhikari, Kandasamy Pachamuthu, Xiaojing Wang, Michael T. Migawa, Richard H. Griffey
  • TRYPTAMINE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN GASTROPATHY
    Publication number: 20130197052
    Abstract: The synthesis and evaluation of gastroprotective effect of different tryptamine derivatives. Tryptamine derivatives have been synthesized by formation of amide or ester with some known anti oxidant molecules. These derivatives show excellent antioxidant property in vitro. Among all the derivatives the compound SEGA (3a), that was prepared by the combination of serotonin with gallic acid shows the greater antioxidant property than the other synthesized compounds both in vivo and in vitro. SEGA(3a) shows the gastroprotective effect against NSAIDs (indomethacin or diclofenac)-induced gastropathy in dose dependent manner and also accelerates the healing from injury. It prevents the NSAIDs-induced mitochondrial oxidative stress in vivo. This derivative prevents NSAID-induced mitochondrial oxidative stress-mediated apoptosis in vivo by preventing the activation of caspase 9 and caspase-3 and restores NSAIDs-mediated collapse of mitochondroial transmembrane potential and dehydrogenase activity.
    Type: Application
    Filed: September 14, 2011
    Publication date: August 1, 2013
    Applicants: UNIVERSITY OF CALCUTTA, COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
    Inventors: Uday Bandyopadhyay, Chinmay Pal, Samik Bindu, Susanta Sekhar Adhikari
  • ANTIBACTERIAL 4,5-SUBSTITUTED AMINOGLYCOSIDE ANALOGS HAVING MULTIPLE SUBSTITUENTS
    Publication number: 20130005674
    Abstract: The present invention is directed to analogs of aminoglycoside compounds as well as their preparation and use as prophylactic or therapeutics against microbial infection.
    Type: Application
    Filed: January 5, 2012
    Publication date: January 3, 2013
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: Eric E. Swayze, Stephen Hanessian, Janek Szychowski, Susanta Sekhar Adhikari, Kandasamy Pachamuthu, Xiaojing Wang, Michael T. Migawa, Richard H. Griffey
  • Antibacterial 4,5-substituted aminoglycoside analogs having multiple substituents
    Patent number: 8114856
    Abstract: The present invention is directed to analogs of aminoglycoside compounds as well as their preparation and use as prophylactic or therapeutics against microbial infection.
    Type: Grant
    Filed: January 10, 2011
    Date of Patent: February 14, 2012
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Eric E. Swayze, Stephen Hanessian, Janek Szychowski, Susanta Sekhar Adhikari, Kandasamy Pachamuthu, Xiaojing Wang, Michael T. Migawa, Richard H. Griffey
  • ANTIBACTERIAL 4,5-SUBSTITUTED AMINOGLYCOSIDE ANALOGS HAVING MULTIPLE SUBSTITUENTS
    Publication number: 20110166334
    Abstract: The present invention is directed to analogs of aminoglycoside compounds as well as their preparation and use as prophylactic or therapeutics against microbial infection.
    Type: Application
    Filed: January 10, 2011
    Publication date: July 7, 2011
    Applicant: ISIS Pharmaceuticals,Inc.
    Inventors: Eric E. Swayze, Stephen Hanessian, Janek Szychowski, Susanta Sekhar Adhikari, Kandasamy Pachamuthu, Xiaojing Wang, Michael T. Migawa, Richard H. Griffey
  • Antimicrobial 2-deoxystreptamine compounds
    Patent number: 7943749
    Abstract: The present invention is directed to analogs of paromomycin having a variety of chemical functional groups attached at the 2?-O-position as well as their preparation and use as prophylactic or therapeutics against microbial infection.
    Type: Grant
    Filed: April 27, 2007
    Date of Patent: May 17, 2011
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Stephen Hanessian, Janek Szychowski, Susanta Sekhar Adhikari, Kandasamy Pachamuthu, Michael T. Migawa, Richard H. Griffey, Eric Swayze
  • Antibacterial 4,5-substituted aminoglycoside analogs having multiple substituents
    Patent number: 7893039
    Abstract: The present invention is directed to analogs of aminoglycoside compounds as well as their preparation and use as prophylactic or therapeutics against microbial infection.
    Type: Grant
    Filed: May 30, 2008
    Date of Patent: February 22, 2011
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Eric E. Swayze, Stephen Hanessian, Janek Szychowski, Susanta Sekhar Adhikari, Kandasamy Pachamuthu, Xiaojing Wang, Michael T. Migawa, Richard H. Griffey
  • ANTIBACTERIAL 4,5-SUBSTITUTED AMINOGLYCOSIDE ANALOGS HAVING MULTIPLE SUBSTITUENTS
    Publication number: 20080293649
    Abstract: The present invention is directed to analogs of aminoglycoside compounds as well as their preparation and use as prophylactic or therapeutics against microbial infection.
    Type: Application
    Filed: May 30, 2008
    Publication date: November 27, 2008
    Applicant: ISIS PHARMACEUTICALS, INC.
    Inventors: Eric E. Swayze, Stephen Hanessian, Janek Szychowski, Susanta Sekhar Adhikari, Kandasamy Pachamuthu, Xiaojing Wang, Michael T. Migawa, Richard H. Griffey
  • Substituted oxygen alicyclic compounds, including methods for synthesis thereof
    Patent number: 6566538
    Abstract: The invention provides new methods for preparation of cyclic oxygen compounds, including 2,5-disubstituted tetrahydrofurans, 2,6-disubstituted tetrahydropyrans, 2,7-disubstituted oxepanes and 2,8-oxocanes. The invention also provides new cyclic oxygen compounds and pharmaceutical compositions and therapeutic methods that comprise such compounds.
    Type: Grant
    Filed: June 27, 2002
    Date of Patent: May 20, 2003
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Mukund Shankar Chorghade, Mukund Keshao Gurjar, Palakodety Radha Krishna, Sista Venkata Sai Lalitha, Kashinath Sadalapure, Susanta Sekhar Adhikari, Andappan Murugaiah Subbaiah Murugaiah, Batchu Venkateswara Rao, Levadala Murali Krishna, Sunil Vyankatesh Mhaskar, Gangavaram Vasantha Madhava Sharma, Tangallapally Rajendra Prasad, Punna Sreenivas, Vavilala Goverdhan Reddy, Aminul Islam, Alla Venkata Rama Rao, Hymavathi Lanka, Bethi Sridhar Reddy, Chittineni Hari Prasad
  • Methods of synthesis of substituted tetrahydrofuran compound
    Patent number: 6541647
    Abstract: The invention includes inter alia new methods for preparation of the pharmaceutically active compound 2-(4-fluorophenoxymethyl)-5-(4-N-hydroxyureidyl-1 -butynyl)-tetrahydrofuran and precursors thereof.
    Type: Grant
    Filed: October 2, 2001
    Date of Patent: April 1, 2003
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Mukund Shankar Chorghade, Mukund Keshao Gurjar, Palakodety Radha Krishna, Sista Venkata Sai Lalitha, Kashinath Sadalapure, Susanta Sekhar Adhikari, Andappan Murugaiah Subbaiah Murugaiah, Sunil Vyankatesh Mhaskar, Gangavaram Vasantha Madhava Sharma, Tangallapally Rajendra Prasad, Punna Sreenivas, Vavilala Goverdhan Reddy, Aminul Islam, Chittineni Hari Prasad, Alla Venkata Rama Rao
  • Substituted oxygen alicyclic compounds, including methods for synthesis thereof
    Patent number: 6433197
    Abstract: The invention provides new methods for preparation of cyclic oxygen compounds, including 2,5-disubstituted tetrahydrofurans, 2,6-disubstituted tetrahydropyrans, 2,7-disubstituted oxepanes and 2,8-oxocanes. The invention also provides new cyclic oxygen compounds and pharmaceutical compositions and therapeutic methods that comprise such compounds.
    Type: Grant
    Filed: October 2, 2001
    Date of Patent: August 13, 2002
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Mukund Shankar Chorghade, Mukund Keshao Gurjar, Palakodety Radha Krishna, Sista Venkata Sai Lalitha, Kashinath Sadalapure, Susanta Sekhar Adhikari, Andappan Murugaiah Subbaiah Murugaiah, Batchu Venkateswara Rao, Levadala Murali Krishna, Sunil Vyankatesh Mhaskar, Gangavaram Vasantha Madhava Sharma, Tangallapally Rajendra Prasad, Punna Sreenivas, Vavilala Goverdhan Reddy, Aminul Islam, Alla Venkata Rama Rao, Hymavathi Lanka, Bethi Sridhar Reddy, Chittineni Hari Prasad
  • Substituted oxygen alicyclic compounds, including methods for synthesis thereof
    Publication number: 20020040154
    Abstract: The invention provides new methods for preparation of cyclic oxygen compounds, including 2,5-disubstituted tetrahydrofurans, 2,6-disubstituted tetrahydropyrans, 2,7-disubstituted oxepanes and 2,8-oxocanes. The invention also provides new cyclic oxygen compounds and pharmaceutical compositions and therapeutic methods that comprise such compounds.
    Type: Application
    Filed: October 2, 2001
    Publication date: April 4, 2002
    Inventors: Mukund Shankar Chorghade, Mukund Keshao Gurjar, Palakodety Radha Krishna, Sista Venkata Sai Lalitha, Kashinath Sadalapure, Susanta Sekhar Adhikari, Andappan Murugaiah Subbaiah Murugaiah, Batchu Venkateswara Rao, Levadala Murali Krishna, Sunil Vyankatesh Mhaskar, Gangavaram Vasantha Madhava Sharma, Tangallapally Rajendra Prasad, Punna Sreenivas, Vavilala Goverdhan Reddy, Aminul Islam, Alla Venkata Rama Rao, Hymavathi Lanka, Bethi Sridhar Reddy, Chittineni Hari Prasad
  • Methods for synthesis of substituted tetrahydrofuran compound
    Publication number: 20020035278
    Abstract: The invention includes inter alia new methods for preparation of the pharmaceutically active compound 2-(4-fluorophenoxymethyl)-5-(4-N-hydroxyureidyl-1-butynyl)-tetrahydrofuran and precursors thereof
    Type: Application
    Filed: October 2, 2001
    Publication date: March 21, 2002
    Inventors: Mukund Shankar Chorghade, Mukund Keshao Gurjar, Palakodety Radha Krishna, Sista Venkata Sai Lalitha, Kashinath Sadalapure, Susanta Sekhar Adhikari, Andappan Murugaiah Subbaiah Murugaiah, Sunil Vyankatesh Mhaskar, Gangavaram Vasantha Madhava Sharma, Tangallapally Rajendra Prasad, Punna Sreenivas, Vavilala Goverdhan Reddy, Aminul Islam, Chittineni Hari Prasad, Alla Venkata Rama Rao
  • Methods for synthesis of substituted tetrahydrofuran compound
    Patent number: 6310221
    Abstract: The invention includes inter alia new methods for preparation of the pharmaceutically active compound 2-(4-fluorophenoxymethyl)-5-(4-N-hydroxyureidyl-1-butynyl)-tetrahydrofuran and precursors thereof.
    Type: Grant
    Filed: July 2, 1999
    Date of Patent: October 30, 2001
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Mukund Shankar Chorghade, Mukund Keshao Gurjar, Palakodety Radha Krishna, Sista Venkata Sai Lalitha, Kashinath Sadalapure, Susanta Sekhar Adhikari, Andappan Murugaiah Subbaiah Murugaiah, Sunil Vyankatesh Mhaskar, Gangavaram Vasantha Madhava Sharma, Tangallapally Rajendra Prasad, Punna Sreenivas, Vavilala Goverdhan Reddy, Aminul Islam, Chittineni Hari Prasad, Alla Venkata Rama Rao
  • Substituted oxygen alicyclic compounds, including methods for synthesis thereof
    Patent number: 6306895
    Abstract: The invention provides new methods for preparation of cyclic oxygen compounds, including 2,5-disubstituted tetahydrofurans, 2,6-disubstituted tetrahydropyrans, 2,7-disubstituted oxepanes and 2,8-oxocanes. The invention also provides new cyclic oxygen compounds and pharmaceutical compositions and therapeutic methods that comprise such compounds.
    Type: Grant
    Filed: July 2, 1999
    Date of Patent: October 23, 2001
    Assignee: Millenium Pharmaceuticals, Inc.
    Inventors: Mukund Shankar Chorghade, Mukund Keshao Gurjar, Palakodety Radha Krishna, Sista Venkata Sai Lalitha, Kashinath Sadalapure, Susanta Sekhar Adhikari, Andappan Murugaiah Subbaiah Murugaiah, Batchu Venkateswara Rao, Levadala Murali Krishna, Sunil Vyankatesh Mhaskar, Gangavaram Vasantha Madhava Sharma, Tangallapally Rajendra Prasad, Punna Sreenivas, Vavilala Goverdhan Reddy, Aminul Islam, Alla Venkata Rama Rao, Hymavathi Lanka, Bethi Sridhar Reddy, Chittineni Hari Prasad