Patents by Inventor Sushil Kumar Sharma

Sushil Kumar Sharma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vacuum sealing flange
    Patent number: 10281069
    Abstract: Flange technologies are described for a flange comprising a first and second side. Each side may include a knife edge surface disposed circumferentially around a base surface and a periphery section disposed around the knife edge surface. The knife edge surface and the periphery section are effective to define grooves therebetween. The flange may include an alloy with a relatively high thermal conductivity and yield strength. The flange may include water channels to remove heat.
    Type: Grant
    Filed: October 21, 2014
    Date of Patent: May 7, 2019
    Assignee: Brookhaven Science Associates, LLC
    Inventors: Sushil Kumar Sharma, Lewis Garth Doom, Jr., Christopher Amundsen, Muhammad Aftab Hussain, Frank A. DePaola, Frank Charles Lincoln, Charles Hetzel, Charles S. De La Parra, Paul Edward Palecek, Jr.
  • VACUUM SEALING FLANGE
    Publication number: 20160290537
    Abstract: Flange technologies are described for a flange comprising a first and second side. Each side may include a knife edge surface disposed circumferentially around a base surface and a periphery section disposed around the knife edge surface. The knife edge surface and the periphery section are effective to define grooves therebetween. The flange may include an alloy with a relatively high thermal conductivity and yield strength. The flange may include water channels to remove heat.
    Type: Application
    Filed: October 21, 2014
    Publication date: October 6, 2016
    Inventors: Sushil Kumar Sharma, Lewis Garth Doom, Jr., Christopher Amundsen, Muhammad Aftab Hussain, Frank A. DePaola, Frank Charles Lincoln, Charles Hetzel, Charles S. De La Parra, Paul Edward Palecek, Jr.
  • SMAC PEPTIDOMETICS USEFUL AS IAP INHIBITORS
    Publication number: 20140004101
    Abstract: The present invention is directed to a compound of the formula: or pharmaceutically acceptable salts thereof and use of such compounds for treating proliferative diseases such as cancer, in mammals.
    Type: Application
    Filed: August 29, 2013
    Publication date: January 2, 2014
    Applicant: NOVARTIS AG
    Inventors: Zhuoliang Chen, Christine Hiu-Tung Chen, Mark G. Charest, Miao Dai, Feng He, Lei Huangshu, Ly Luu Pham, Sushil Kumar Sharma, Christopher Sean Straub, Run-Ming David Wang, Fan Yang, Leigh Zawel
  • (S)-N-((S)-1-cyclohexyl-2-{(S)-2-[4-4-(4-fluorobenzoyl)-thiazol-2-yl]pyrrolidin-1-yl}-2-oxoethyl)-2-methylamino-propionamide, or pharmaceutically acceptable salts thereof and their uses
    Patent number: 8552003
    Abstract: The present invention is directed to a compound of the formula: or pharmaceutically acceptable salts thereof and use of such compounds for treating proliferative diseases such as cancer, in mammals.
    Type: Grant
    Filed: July 31, 2007
    Date of Patent: October 8, 2013
    Assignee: Novartis AG
    Inventors: Mark G. Charest, Christine Hiu-Tung Chen, Zhuoliang Chen, Miao Dai, Feng He, Huangshu Lei, Ly Luu Pham, Sushil Kumar Sharma, Christopher Sean Straub, Run-Ming David Wang, Fan Yang, Leigh Zawel
  • SMAC peptidometics useful as IAP inhibitors
    Patent number: 8546336
    Abstract: The present invention is directed to a compound of the formula: or pharmaceutically acceptable salts thereof and use of such compounds for treating proliferative diseases such as cancer, in mammals.
    Type: Grant
    Filed: September 7, 2012
    Date of Patent: October 1, 2013
    Assignee: Novartis AG
    Inventors: Zhuoliang Chen, Mark G. Charest, Christine Hiu-Tung Chen, Miao Dai, Feng He, Huangshu Lei, Ly Luu Pham, Sushil Kumar Sharma, Christopher Sean Straub, Run-Ming David Wang, Fan Yang, Leigh Zawel
  • SMAC PEPTIDOMETICS USEFUL AS IAP INHIBITORS
    Publication number: 20130005663
    Abstract: The present invention is directed to a compound of the formula: or pharmaceutically acceptable salts thereof and use of such compounds for treating proliferative diseases such as cancer, in mammals.
    Type: Application
    Filed: September 7, 2012
    Publication date: January 3, 2013
    Applicant: NOVARTIS AG
    Inventors: Mark G. CHAREST, Christine Hiu-Tung CHEN, Zhuoliang CHEN, Miao DAI, Feng HE, Huangshu LEI, Ly Luu PHAM, Sushil Kumar SHARMA, Christopher Sean STRAUB, Run-Ming David WANG, Fan YANG, Leigh ZAWEL
  • Inhibitors of IAP
    Patent number: 8338440
    Abstract: Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula (I).
    Type: Grant
    Filed: April 26, 2012
    Date of Patent: December 25, 2012
    Inventors: Mark G. Palermo, Sushil Kumar Sharma, Christopher Sean Straub, Run-Ming Wang, Leigh Zawel, Yanlin Zhang, Zhuoliang Chen, Yaping Wang, Fan Yang, Wojciech Wrona, Gang Liu, Mark G. Charest, Feng He
  • Inhibitors of IAP
    Publication number: 20120207769
    Abstract: Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula (I).
    Type: Application
    Filed: April 26, 2012
    Publication date: August 16, 2012
    Applicant: NOVARTIS AG
    Inventors: Mark G. PALERMO, Sushil Kumar SHARMA, Christopher STRAUB, Run-Ming WANG, Leigh ZAWEL, Yanlin ZHANG, Zhuoliang CHEN, Yaping WANG, Fan YANG, Wojciech WRONA, Gang LIU, Mark G. CHAREST, Feng HE
  • Inhibitors of IAP
    Patent number: 8207183
    Abstract: Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula (I).
    Type: Grant
    Filed: July 8, 2011
    Date of Patent: June 26, 2012
    Assignee: Novartis AG
    Inventors: Mark G. Palermo, Sushil Kumar Sharma, Christopher Sean Straub, Run-Ming Wang, Leigh Zawel, Yanling Zhang, Zhuoliang Chen, Yaping Wang, Fan Yang, Wojciech Wrona, Gang Liu, Mark G. Charest, Feng He
  • Inhibitors of IAP
    Publication number: 20110281875
    Abstract: Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula (I).
    Type: Application
    Filed: July 8, 2011
    Publication date: November 17, 2011
    Inventors: Mark G. PALERMO, Sushil Kumar SHARMA, Christopher STRAUB, Run-Ming WANG, Leigh ZAWEL, Yanlin ZHANG, Zhuoliang CHEN, Yaping WANG, Fan YANG, Wojciech WRONA, Gang LIU, Mark G. CHAREST, Feng HE
  • Organic Compounds
    Publication number: 20110065726
    Abstract: The present invention is directed to a compound of the formula: or pharmaceutically acceptable salts thereof and use of such compounds for treating proliferative diseases such as cancer, in mammals.
    Type: Application
    Filed: July 31, 2007
    Publication date: March 17, 2011
    Inventors: Zhuoliang CHEN, Sushil Kumar Sharma, Christopher Straub, Mark G. Charest, Feng He, Run-Ming David Wang, Leigh Zawel, Christine Hiu-Tung Chen, Miao Dai, Huangshu Lei, Ly Pham, Fan Yang
  • Inhibitors of Iap
    Publication number: 20080242658
    Abstract: Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula I
    Type: Application
    Filed: April 6, 2005
    Publication date: October 2, 2008
    Inventors: Mark G Palermo, Sushil Kumar Sharma, Christopher Straub, Run-Ming Wang, Leigh Zawel, Yanlin Zhang, Zhuoliang Chen, Yaping Wang, Fan Yang, Wojciech Wrona, Gang Liu, Mark G. Charest, Feng He
  • Organic compounds
    Patent number: 7419975
    Abstract: Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula I
    Type: Grant
    Filed: April 6, 2005
    Date of Patent: September 2, 2008
    Assignee: Novartis AG
    Inventors: Mark Gabriel Palermo, Sushil Kumar Sharma, Christopher Straub, Run-Ming Wang, Leigh Scott Zawel, Yanlin Zhang, Zhuoliang Chen, Yaping Wang, Fan Yang, Wojciech Wrona, Gang Liu, Mark G. Charest, Feng He
  • Inhibitors of the E2F-1/cyclin interaction for cancer therapy
    Publication number: 20040077549
    Abstract: The novel compounds of this invention have the general structural formula Ia-d: The compounds of this invention relate to 8-mer, 7-mer, 6-mer and 5-mer peptides having the following amino acid-sequences, and referred to collectively as having “Formula Ia-d”: 1 Cap-AA8-AA7-AA6-AA5-AA4*-AA3-AA2-AA1* 8-mer la Cap-AA7-AA6-AA5-AA4*-AA3-AA2-AA1* 7-mer lb Cap-AA6-AA5-AA4*-AA3-AA2-AA1* 6-mer lc Cap-AA5-AA4*-AA3-AA2-AA1* 5-mer ld
    Type: Application
    Filed: June 27, 2003
    Publication date: April 22, 2004
    Inventors: Kenneth Walter Bair, YingNan Pan Chen, Timothy Michael Ramsey, Michael Lloyd Sabio, Sushil Kumar Sharma
  • Inhibitors of the E2F-1/cyclin interaction for cancer therapy
    Publication number: 20040053849
    Abstract: The novel compounds of this invention have the general structural formula Ia-d: The compounds of this invention relate to 8-mer, 7-mer, 6-mer and 5-mer peptides having the following amino acid sequences, and referred to collectively as having “Formula Ia-d”: 1 Cap-AA8-AA7-AA6-AA5-AA4*-AA3-AA2-AA1* 8-mer Ia Cap-AA7-AA6-AA5-AA4*-AA3-AA2-AA1* 7-mer Ib Cap-AA6-AA5-AA4*-AA3-AA2-AA1* 6-mer Ic Cap-AA5-AA4*-AA3-AA2-AA1* 5-mer Id
    Type: Application
    Filed: June 25, 2003
    Publication date: March 18, 2004
    Inventors: Kenneth Walter Bair, YingNan Pan Chen, Timothy Michael Ramsey, Michael Lloyd Sabio, Sushil Kumar Sharma
  • Inhibitors of the E2F-1/cyclin interaction for cancer therapy
    Publication number: 20020142966
    Abstract: The novel compounds of this invention have the general structural formula Ia-d: The compounds of this invention relate to 8-mer, 7-mer, 6-mer and 5-mer peptides having the following amino acid sequences, and referred to collectively as having “Formula Ia-d”: 1 Cap-AA8-AA7-AA6-AA5-AA4*-AA3-AA2-AA1* 8-mer Ia Cap-AA7-AA6-AA5-AA4*-AA3-AA2-AA1* 7-mer Ib Cap-AA6-AA5-AA4*-AA3-AA2-AA1* 6-mer Ic Cap-AA5-AA4*-AA3-AA2-AA1* 5-mer Id
    Type: Application
    Filed: December 19, 2001
    Publication date: October 3, 2002
    Inventors: Kenneth Walter Bair, YingNan Pan Chen, Timothy Michael Ramsey, Michael Lloyd Sabio, Sushil Kumar Sharma