Abstract: Compositions and methods for multiplex delivery and gene editing in vitro are provided.

Abstract: A apparatus is provided that includes a plurality of wireless sensors arranged into a mesh network, wherein each of the plurality of sensors detects threats within a secured geographic area, a processor of each of the plurality of sensors that detects operational and environmental operating conditions of a respective one of the plurality of sensors and reports the operational and environmental operating conditions, a control panel processor that receives and correlates at least one of the operational and environmental operating conditions of the respective one of the plurality of sensors to a potential failure mode and reports the potential failure mode to a cloud application, and a cloud processor of the cloud application that determines a location of the respective one of the plurality of sensors and reports the potential failure mode and the location to a person responsible for the respective one of the plurality of sensors.

Abstract: A apparatus including a plurality of wireless sensors arranged into a mesh network where each of the plurality of sensors detect threats within a secured geographic area, a processor of each of the plurality of sensors that detects operational and environmental operating conditions of the sensor and reports the detected conditions, a processor that receives and correlates at least one of the detected conditions of a sensor to a potential failure mode and reports the potential failure mode to a cloud app and a cloud processor of the cloud app that determines a location of the sensor and reports the potential failure and location to a person responsible for the sensor.

Abstract: In an example, a system and method is disclosed for providing a user matching system. To ease creation of a profile, a node may be enabled to connect to a third-party social media site where the node already has an established profile. The established profile is imported, wherein common fields are directly mapped, inferred fields may be deterministically inferred, and other fields such as “likes” may be assigned relative weights based on recentness, subjective user rankings, or correlation to other “likes.” The node may also be enabled to permanently log in to the matching system via credentials for the third-party social media site.

Abstract: In an example, a system and method is disclosed for providing a user matching system. To ease creation of a profile, a node may be enabled to connect to a third-party social media site where the node already has an established profile. The established profile is imported, wherein common fields are directly mapped, inferred fields may be deterministically inferred, and other fields such as “likes” may be assigned relative weights based on recentness, subjective user rankings, or correlation to other “likes.” The node may also be enabled to permanently log in to the matching system via credentials for the third-party social media site.

Abstract: A system and method identify the person who is using a keyboard based on keystroke latencies as the person types certain key combinations. In some embodiments the latencies are monitored as the person types a password, while in others they are monitored as the person types other information and continues to use the computer. In some embodiments the identification yields a binary result (whether the latency profile matches the profile stored for a particular user), while in others a confidence level is given. A mismatch, or a confidence level below a particular threshold, results in a request for further identity verification, creation of a log entry, immediate notification of responsible personnel, or denial of access (or continued access).

Abstract: The present invention provides hydroxamate compounds which are deacetylase inhibitors. The compounds are suitable for pharmaceutical compositions having anti-proliferative properties.

Abstract: A system and method identify the person who is using a keyboard based on keystroke latencies as the person types certain key combinations. In some embodiments the latencies are monitored as the person types a password, while in others they are monitored as the person types other information and continues to use the computer. In some embodiments the identification yields a binary result (whether the latency profile matches the profile stored for a particular user), while in others a confidence level is given. A mismatch, or a confidence level below a particular threshold, results in a request for further identity verification, creation of a log entry, immediate notification of responsible personnel, or denial of access (or continued access).

Abstract: The present invention provides hydroxamate compounds which are deacetylase inhibitors. The compounds are suitable for pharmaceutical compositions having anti-proliferative properties.

Abstract: The present invention provides hydroxamate compounds which are deacetylase inhibitors. The compounds are suitable for pharmaceutical compositions having anti-proliferative properties.

Abstract: The present disclosure relates to XIAP inhibitor compounds of the formula I wherein the substituents are as described in the specification. The inventive compounds are useful as therapeutic agents for the treatment of proliferative disorders, including cancer.

Abstract: The present disclosure relates to XIAP inhibitor compounds of the formula I wherein the substituents are as described in the specification. The inventive compounds are useful as therapeutic agents for the treatment of proliferative disorders, including cancer.

Abstract: Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula I

Abstract: The present invention provides hydroxamate compounds which are deacetylase inhibitors. The compounds are suitable for pharmaceutical compositions having anti-proliferative properties.

Abstract: The present invention provides hydroxamate compounds which are deacetylase inhibitors. The compounds are suitable for pharmaceutical compositions having anti-proliferative properties.

Abstract: The present invention provides hydroxamate compounds which are deacetylase inhibitors. The compounds are suitable for pharmaceutical compositions having anti-proliferative properties.

Abstract: The present invention provides hydroxamate compounds which are deacetylase inhibitors. The compounds are suitable for pharmaceutical compositions having anti-proliferative properties.

Abstract: A plasma valve includes a confinement channel and primary anode and cathode disposed therein. An ignition cathode is disposed adjacent the primary cathode. Power supplies are joined to the cathodes and anode for rapidly igniting and maintaining a plasma in the channel for preventing leakage of atmospheric pressure through the channel.

Abstract: The present invention provides hydroxamate compounds which are deacetylase inhibitors. The compounds are suitable for pharmaceutical compositions having anti-proliferative properties.

Abstract: An improved process for producing a water-soluble polymyxin B/dextran conjugate comprises the step of reacting polymyxin B or pharmaceutically acceptable salt thereof with dextran in an aqueous media at a pH of about 9.3 to 10.