Patents by Inventor Sushrut KAMERKAR

Sushrut KAMERKAR has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR PRODUCTION OF MSC-DERIVED EXOSOMES
    Publication number: 20230390201
    Abstract: Provided herein are methods of manufacturing clinical grade exosomes derived from mesenchymal stem cells (MSCs). Further provided are methods of loading the exosomes with therapeutic agents, such as siRNA. Also provided herein are methods of treating diseases by administering the clinical grade exosome.
    Type: Application
    Filed: August 11, 2023
    Publication date: December 7, 2023
    Inventors: Elizabeth SHPALL, Raghu KALLURI, Katy REZVANI, Mayela MENDT, Valerie LEBLEU, Sushrut KAMERKAR
  • EXTRACELLULAR VESICLE-ASO CONSTRUCTS TARGETING STAT6
    Publication number: 20230364127
    Abstract: The present disclosure relates to extracellular vesicles, e.g., exosomes, comprising an antisense oligonucleotide (ASO), wherein the ASO comprises a contiguous nucleotide sequence of 10 to 30 nucleotides in length that is complementary to a nucleic acid sequence within a STAT6 transcript. Also provided herein are methods for producing the exosomes and methods for using the exosomes to treat and/or prevent diseases or disorders.
    Type: Application
    Filed: October 6, 2021
    Publication date: November 16, 2023
    Applicant: CODIAK BIOSCIENCES, INC.
    Inventors: Tim SOOS, Sushrut KAMERKAR, Su Chul JANG, Kyriakos ECONOMIDES, Dalia BURZYN
  • METHODS AND COMPOSITIONS FOR MACROPHAGE POLARIZATION
    Publication number: 20230365971
    Abstract: Disclosed herein are compositions and methods comprising extracellular vesicles comprising nucleic acid that target genes, leading to macrophage polarization of tumor associated macrophages. In certain embodiments, disclosed herein are methods and compositions for increasing macrophage polarization for the treatment of cancer.
    Type: Application
    Filed: November 4, 2022
    Publication date: November 16, 2023
    Applicant: CODIAK BIOSCIENCES, INC.
    Inventors: Sriram SATHYANARAYANAN, Douglas E. WILLIAMS, Dalia BURZYN, Adam Thomas BOUTIN, Sushrut KAMERKAR
  • Methods for production of MSC-derived exosomes
    Patent number: 11766402
    Abstract: Provided herein are methods of manufacturing clinical grade exosomes derived from mesenchymal stem cells (MSCs). Further provided are methods of loading the exosomes with therapeutic agents, such as siRNA. Also provided herein are methods of treating diseases by administering the clinical grade exosomes.
    Type: Grant
    Filed: November 16, 2018
    Date of Patent: September 26, 2023
    Assignee: Board of Regents, The University of Texas System
    Inventors: Elizabeth Shpall, Raghu Kalluri, Katy Rezvani, Mayela Mendt, Valerie Lebleu, Sushrut Kamerkar
  • EXTRACELLULAR VESICLES WITH ANTISENSE OLIGONUCLEOTIDES TARGETING KRAS
    Publication number: 20230018254
    Abstract: The present disclosure relates to modified extracellular vesicles, e.g., exosomes, comprising an antisense oligonucleotide (ASO), which is capable of reducing and/or inhibiting expression of KRAS mRNA and/or KRAS protein. ASOs that can be used with the modified extracellular vesicles are also disclosed. Also provided herein are methods for using the exosomes and ASOs to treat and/or prevent diseases, such as cancer.
    Type: Application
    Filed: August 14, 2020
    Publication date: January 19, 2023
    Applicant: Codiak BioSciences, Inc.
    Inventors: Dalia BURZYN, Sushrut KAMERKAR, Adam T. BOUTIN, Wendy BROOM, Sriram SATHYANARAYANAN, Monique KAUKE, Stephanie YU, Michael BOCKER
  • EXTRACELLULAR VESICLE-ASO CONSTRUCTS TARGETING CEBP/BETA
    Publication number: 20230002764
    Abstract: The present disclosure relates to extracellular vesicles, e.g., exosomes, comprising an antisense oligonucleotide (ASO), wherein the ASO comprises a contiguous nucleotide sequence of 10 to 30 nucleotides in length that is complementary to a nucleic acid sequence within a CEBP/transcript. Also provided herein are methods for producing the exosomes and methods for using the exosomes to treat and/or prevent diseases or disorders.
    Type: Application
    Filed: August 14, 2020
    Publication date: January 5, 2023
    Applicant: Codiak BioSciences, Inc.
    Inventors: Dalia BURZYN, Sushrut KAMERKAR, Adam T. BOUTIN, Wendy BROOM, Sriram SATHYANARAYANAN, Ajay VERMA
  • Methods and compositions for macrophage polarization
    Patent number: 11512315
    Abstract: Disclosed herein are compositions and methods comprising extracellular vesicles comprising nucleic acid that target genes, leading to macrophage polarization of tumor associated macrophages. In certain embodiments, disclosed herein are methods and compositions for increasing macrophage polarization for the treatment of cancer.
    Type: Grant
    Filed: February 12, 2019
    Date of Patent: November 29, 2022
    Assignee: CODIAK BIOSCIENCES, INC.
    Inventors: Sriram Sathyanarayanan, Douglas E. Williams, Dalia Burzyn, Adam Thomas Boutin, Sushrut Kamerkar
  • METHODS FOR PRODUCTION OF MSC-DERIVED EXOSOMES
    Publication number: 20210186877
    Abstract: Provided herein are methods of manufacturing clinical grade exosomes derived from mesenchymal stem cells (MSCs). Further provided are methods of loading the exosomes with therapeutic agents, such as siRNA. Also provided herein are methods of treating diseases by administering the clinical grade exosomes.
    Type: Application
    Filed: November 16, 2018
    Publication date: June 24, 2021
    Inventors: Elizabeth Shpall, Raghu Kalluri, Katy Rezvani, Mayela Mendt, Valerie Lebleu, Sushrut Kamerkar
  • METHODS AND COMPOSITIONS FOR MACROPHAGE POLARIZATION
    Publication number: 20200407725
    Abstract: Disclosed herein are compositions and methods comprising extracellular vesicles comprising nucleic acid that target genes, leading to macrophage polarization of tumor associated macrophages. In certain embodiments, disclosed herein are methods and compositions for increasing macrophage polarization for the treatment of cancer.
    Type: Application
    Filed: February 12, 2019
    Publication date: December 31, 2020
    Applicant: CODIAK BIOSCIENCES, INC.
    Inventors: Sriram SATHYANARAYANAN, Douglas E. WILLIAMS, Dalia BURZYN, Adam Thomas BOUTIN, Sushrut KAMERKAR