Abstract: The present disclosure provides methods for printing a three-dimensional (3D) object, comprising processing a computer model of the 3D object to generate a strength or stress profile of the computer model. Next at least (i) the strength or stress profile from processing the computer model and (ii) a topology of the 3D object may be used to generate a tool path for printing the 3D object. Printing of the 3D object may be simulated using the tool path to yield a simulated 3D object. The simulated 3D object may be analyzed to determine whether the simulated 3D object meets a threshold. If the simulated 3D object meets the threshold, printing instructions comprising the tool path may be generated for use by a 3D printer to print the 3D object.