Patents by Inventor Susumu Hoshiko
Susumu Hoshiko has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9541564Abstract: The present invention provides a reagent for assaying D-dimer which includes carriers sensitized to first and second monoclonal antibodies which react with D-dimer, but have different reactivity to D-dimer in which the first monoclonal antibody reacts with high- and low-molecular fractions of D-dimer, the second monoclonal antibody reacts with the high-molecular fraction, but reactivity of the second monoclonal antibody with the low-molecular fraction is different from that of the first monoclonal antibody and a kit of reagent for assaying D-dimer.Type: GrantFiled: April 18, 2016Date of Patent: January 10, 2017Assignee: SYSMEX CORPORATIONInventors: Keisuke Nagai, Kazuaki Yamashita, Susumu Hoshiko, Takeshi Suzuki
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Publication number: 20160231339Abstract: The present invention provides a reagent for assaying D-dimer which includes carriers sensitized to first and second monoclonal antibodies which react with D-dimer, but have different reactivity to D-dimer in which the first monoclonal antibody reacts with high- and low-molecular fractions of D-dimer, the second monoclonal antibody reacts with the high-molecular fraction, but reactivity of the second monoclonal antibody with the low-molecular fraction is different from that of the first monoclonal antibody and a kit of reagent for assaying D-dimer.Type: ApplicationFiled: April 18, 2016Publication date: August 11, 2016Applicant: SYSMEX CORPORATIONInventors: Keisuke NAGAI, Kazuaki YAMASHITA, Susumu HOSHIKO, Takeshi SUZUKI
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Patent number: 9347957Abstract: The present invention provides a reagent for assaying D-dimer which includes carriers sensitized to first and second monoclonal antibodies which react with D-dimer, but have different reactivity to D-dimer in which the first monoclonal antibody reacts with high- and low-molecular fractions of D-dimer, the second monoclonal antibody reacts with the high-molecular fraction, but reactivity of the second monoclonal antibody with the low-molecular fraction is different from that of the first monoclonal antibody and a kit of reagent for assaying D-dimer.Type: GrantFiled: July 25, 2011Date of Patent: May 24, 2016Assignee: SYSMEX CORPORATIONInventors: Keisuke Nagai, Kazuaki Yamashita, Susumu Hoshiko, Takeshi Suzuki
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Patent number: 8936753Abstract: A blood coagulation analyzer includes a detector and a controller. The detector includes a light source for emitting light to a prepared measurement sample and a light-receiving section for receiving light transmitted through the measurement sample. The controller is configured to performs operations comprising acquiring, based on the light detected by the detector, ratio information reflecting a ratio between a first value reflecting the intensity of the light transmitted through the measurement sample of a clotting reaction starting stage and a second value reflecting the intensity of the light transmitted through the measurement sample of a clotting reacting ending stage, and acquiring, based on the ratio information, a fibrinogen concentration in the blood sample.Type: GrantFiled: September 29, 2010Date of Patent: January 20, 2015Assignee: Sysmex CorporationInventors: Norimasa Yamamoto, Hiroyuki Fujino, Takamichi Naito, Naohiko Matsuo, Susumu Hoshiko
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Patent number: 8753808Abstract: A platelet aggregation measuring method comprising: preparing a measurement sample which contains a sample and a reagent which includes a platelet activator; mixing the measurement sample at a first speed; mixing the measurement sample at a second speed which is greater than the first speed after mixing the sample at the first speed; obtaining optical information from the measurement sample while mixing the measurement sample at the second speed; and analyzing aggregation of platelets in the sample based on the optical information is disclosed. A platelet aggregation measuring apparatus is also disclosed.Type: GrantFiled: June 26, 2008Date of Patent: June 17, 2014Assignee: Sysmex CorporationInventors: Susumu Hoshiko, Katsushi Kobayashi
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Publication number: 20120028370Abstract: The present invention provides a reagent for assaying D-dimer which includes carriers sensitized to first and second monoclonal antibodies which react with D-dimer, but have different reactivity to D-dimer in which the first monoclonal antibody reacts with high- and low-molecular fractions of D-dimer, the second monoclonal antibody reacts with the high-molecular fraction, but reactivity of the second monoclonal antibody with the low-molecular fraction is different from that of the first monoclonal antibody and a kit of reagent for assaying D-dimer.Type: ApplicationFiled: July 25, 2011Publication date: February 2, 2012Applicant: SYSMEX CORPORATIONInventors: Keisuke NAGAI, Kazuaki YAMASHITA, Susumu HOSHIKO, Takeshi SUZUKI
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Patent number: 7962292Abstract: A sample analyzer optically measures reaction of a sample mixed with reagent, and obtains optical information therefrom; generates a reaction curve representing change in the optical information over time; determines a first area prior to an evaluation target time (t0) and a second area after the evaluation target time (t0) wherein the first and second areas are formed between a baseline which is parallel to the time axis and a reaction curve from a first time (t1) prior to the optional evaluation target time (t0) to a second time (t2) after the evaluation target time, and determines the reaction end point based on the first and second areas; and obtains a characteristic of a sample based on the determined reaction end point, is disclosed. a sample analyzing method is also disclosed.Type: GrantFiled: January 31, 2008Date of Patent: June 14, 2011Assignee: Sysmex CorporationInventors: Naohiko Matsuo, Hiroyuki Fujino, Mitsuyo Koya, Susumu Hoshiko
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Publication number: 20110014640Abstract: A blood coagulation analyzer is provided by which, while the measurement using reagent for measuring a Fbg (fibrinogen concentration) is being minimized, the result of a measurement such as a PT measurement can be used to accurately acquire a fibrinogen concentration.Type: ApplicationFiled: September 29, 2010Publication date: January 20, 2011Inventors: Norimasa Yamamoto, Hiroyuki Fujino, Takamichi Naito, Naohiko Matsuo, Susumu Hoshiko
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Patent number: 7842509Abstract: A blood analyzer has a light emitter for emitting light to an analysis sample which is a mixture of a blood specimen and a reagent. It also has a light receiver for receiving light of a plurality of wavelengths from the analysis sample over time, and for acquiring data of the amount of the received light corresponding to each of the wavelengths at a plurality of points of time. A selector selects the data corresponding to one of the wavelengths, based on the change of the amount of received light over time in the data acquired by the light receiver. An analysis section analyzes a characteristic of the blood specimen using the data which are selected by the selector. A blood analyzing method is also described.Type: GrantFiled: March 30, 2007Date of Patent: November 30, 2010Assignee: Sysmex CorporationInventors: Naohiko Matsuo, Susumu Hoshiko, Norimasa Yamamoto, Mitsuyo Ito
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Patent number: 7760340Abstract: A sample analyzer includes (a) a measuring part for measuring optical information of a sample at first wavelength, second wavelength, and third wavelength, first light of the first wavelength and second light of the second wavelength being absorbed by a second substance but substantially not absorbed by a first substance, and third light of the third wavelength being absorbed by the first substance; and (b) an obtaining part for obtaining content of the first substance in the sample, and content of the second substance in the sample, influence by the second substance being excluded from the content of the first substance, based on the optical information at the first wavelength, second wavelength, and third wavelength measured by the measuring part.Type: GrantFiled: March 16, 2007Date of Patent: July 20, 2010Assignee: Sysmex CorporationInventors: Susumu Hoshiko, Naohiko Matsuo, Katsushi Kobayashi, Norimasa Yamamoto
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Publication number: 20090061468Abstract: A reagent kit for measuring coagulation time is described herein. This reagent comprises calcium chelator which interferes with the reaction between calcium and substance other than a coagulation factor in a blood sample, and which substantially does not interfere with coagulation reaction. A method for measuring coagulation time is also described herein. The method comprises a contacting step and a measuring step. The contacting step is to contact a blood sample, calcium and compound selected from the group consisting of partial thromboplastin, tissue thromboplastin, and complex of tissue factor and phospholipid, in the presence of calcium chelator. This calcium chelator can interfere with the reaction between calcium and substance other than a coagulation factor in the blood sample and substantially does not interfere with coagulation reaction. The measuring step is to measure coagulation time of the blood sample.Type: ApplicationFiled: August 20, 2008Publication date: March 5, 2009Applicant: SYSMEX CORPORATIONInventors: Susumu HOSHIKO, Katsushi Kobayashi
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Publication number: 20090004681Abstract: A platelet aggregation measuring method comprising: preparing a measurement sample which contains a sample and a reagent which includes a platelet activator; mixing the measurement sample at a first speed; mixing the measurement sample at a second speed which is greater than the first speed after mixing the sample at the first speed; obtaining optical information from the measurement sample while mixing the measurement sample at the second speed; and analyzing aggregation of platelets in the sample based on the optical information is disclosed. A platelet aggregation measuring apparatus is also disclosed.Type: ApplicationFiled: June 26, 2008Publication date: January 1, 2009Applicant: SYSMEX CORPORATIONInventors: Susumu Hoshiko, Katsushi Kobayashi
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Publication number: 20080183431Abstract: A sample analyzer optically measures reaction of a sample mixed with reagent, and obtains optical information therefrom; generates a reaction curve representing change in the optical information over time; determines a first area prior to an evaluation target time (t0) and a second area after the evaluation target time (t0) wherein the first and second areas are formed between a baseline which is parallel to the time axis and a reaction curve from a first time (t1) prior to the optional evaluation target time (t0) to a second time (t2) after the evaluation target time, and determines the reaction end point based on the first and second areas; and obtains a characteristic of a sample based on the determined reaction end point, is disclosed a sample analyzing method is also disclosed.Type: ApplicationFiled: January 31, 2008Publication date: July 31, 2008Inventors: Naohiko Matsuo, Hiroyuki Fujino, Mitsuyo Koya, Susumu Hoshiko
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Publication number: 20070248490Abstract: A blood analyzer has a light emitter for emitting light to an analysis sample which is a mixture of a blood specimen and a reagent. It also has a light receiver for receiving light of a plurality of wavelengths from the analysis sample over time, and for acquiring data of the amount of the received light corresponding to each of the wavelengths at a plurality of points of time. A selector selects the data corresponding to one of the wavelengths, based on the change of the amount of received light over time in the data acquired by the light receiver. An analysis section analyzes a characteristic of the blood specimen using the data which are selected by the selector. A blood analyzing method is also described.Type: ApplicationFiled: March 30, 2007Publication date: October 25, 2007Applicant: SYSMEX CORPORATIONInventors: Naohiko Matsuo, Susumu Hoshiko, Norimasa Yamamoto, Mitsuyo Ito
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Patent number: 7276376Abstract: An analyzing method of a blood coagulation reaction by detecting an optical change of a blood sample with an elapse of time, the method includes: setting at least one checkpoint or check region between a starting point of the blood coagulation reaction and the endpoint thereof; and monitoring a reaction state of the blood coagulation reaction at the checkpoint or in the check region to detect an abnormality of the blood coagulation reaction.Type: GrantFiled: December 3, 2002Date of Patent: October 2, 2007Assignees: Sysmex Corporation, Dade Behring Marburg GmbHInventors: Masayuki Katayama, Susumu Hoshiko, Takayoshi Izumi, Yoshihiro Mishima, Wilfried Meyers, Norbert Zander
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Publication number: 20070222973Abstract: A sample analyzer comprising: a measuring part for measuring optical information of a sample at first wavelength, second wavelength, and third wavelength, first light of the first wavelength and second light of the second wavelength being absorbed by a second substance but substantially not absorbed by a first substance, and third light of the third wavelength being absorbed by the first substance; and an obtaining means for obtaining content of the first substance in the sample, and content of the second substance in the sample, influence by the second substance being excluded from the content of the first substance, based on the optical information at the first wavelength, second wavelength, and third wavelength measured by the measuring part.Type: ApplicationFiled: March 16, 2007Publication date: September 27, 2007Inventors: Susumu Hoshiko, Naohiko Matsuo, Katsushi Kobayashi, Norimasa Yamamoto
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Publication number: 20050202509Abstract: The present invention provides a reagent for measuring clotting time that allows accurate analysis of blood coagulation in samples containing antiphospholipid antibodies, wherein the clotting time is measured by using a sample containing an antiphospholipid antibody, a causative substance of antiphospholipid antibody syndromes, and the reagent for measuring clotting time containing antibody, serum, plasma and immunoglobulin of vertebrates except human.Type: ApplicationFiled: November 24, 2004Publication date: September 15, 2005Inventors: Masahiro Okuda, Susumu Hoshiko
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Publication number: 20030138962Abstract: An analyzing method of a blood coagulation reaction by detecting an optical change of a blood sample with an elapse of time, the method comprises: setting at least one checkpoint or check region between a starting point of the blood coagulation reaction and the endpoint thereof; and monitoring a reaction state of the blood coagulation reaction at the checkpoint or in the check region to detect an abnormality of the blood coagulation reaction.Type: ApplicationFiled: December 3, 2002Publication date: July 24, 2003Inventors: Masayuki Katayama, Susumu Hoshiko, Takayoshi Izumi, Yoshihiro Mishima, Wilfried Meyers, Norbert Zander
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Patent number: 6114292Abstract: A method of using a cleansing composition for cleansing a quantitatively aspirating sampling probe in an automated hematological analyzer is disclosed. The cleansing composition employed in the method is formulated to cleanse instantaneously on contact, and practically eliminates carry-over of hematological sample material, assaying reagents or of the cleansing composition itself. The cleansing composition is an acidic aqueous solution of pH 5.0 or less, including (1) a substance having a primary amino group; and (2) one or more nonionic surfactants selected from the group consisting of polyoxyethylene alkyl ether, polyoxyethylene alkyl phenyl ether, polyoxyethylene alkyl ester and polyoxyethylene sorbitan ester. Assay-material contaminated surfaces of the sampling probe are contacted with a cleansing amount of the cleansing composition.Type: GrantFiled: January 20, 2000Date of Patent: September 5, 2000Assignee: Sysmex CorporationInventors: Susumu Hoshiko, Miki Miyaji
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Patent number: 6043205Abstract: A cleansing composition and method of use are disclosed for cleansing a quantitatively aspirating sampling probe in an automated hematological analyzer. The cleansing composition is formulated to cleanse instantaneously on contact, and practically eliminates carry-over of hematological sample material, assaying reagents or of the cleansing composition itself. The cleansing composition is an acidic aqueous solution of pH 5.0 or less, including (1) a substance having a primary amino group; and (2) one or more nonionic surfactants selected from the group consisting of polyoxyethylene alkyl ether, polyoxyethylene alkyl phenyl ether, polyoxyethylene alkyl ester and polyoxyethylene sorbitan ester.Type: GrantFiled: September 29, 1998Date of Patent: March 28, 2000Assignee: Sysmex CorporationInventors: Susumu Hoshiko, Miki Miyaji