Patents by Inventor Susumu Kashiwabara

Susumu Kashiwabara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9687592
    Abstract: A method for manufacturing a nerve regeneration-inducing tube with excellent pressure resistance, shape recovery property, anti-kink property, film exfoliation resistance, resistance to invasion of outer tissues, and leakage resistance. The tubular body is formed by weaving together fibers made up of biodegradable polymer. The outer surface of the tubular body is coated multiple times with a collagen solution. The lumen of the tubular body is filled with collagen. Viscosity of the collagen solution that is first applied to the outer surface of the tubular body is between 2 to 800 cps. Viscosity of the collagen solution that is subsequently applied is higher than viscosity of the first applied collagen solution.
    Type: Grant
    Filed: December 13, 2013
    Date of Patent: June 27, 2017
    Assignee: TOYO BOSEKI KABUSHIKI KAISHA
    Inventors: Fumihiko Kajii, Hidenori Tanaka, Yuta Kawakatsu, Susumu Kashiwabara, Masaki Sato
  • Publication number: 20150190551
    Abstract: A problem that the present invention is to solve is to provide a pellet-shaped composition for medical use mainly comprising a polyvinyl chloride resin and exhibiting antithrombotic property when merely being molded. The present invention is a pellet-shaped composition for medical use which comprises 1 to 120 part(s) by weight of a plasticizer and 0.01 to 5 part(s) by weight of a (meth)acrylate copolymer containing a hydrophobic (meth)acrylate unit and a hydrophilic (meth)acrylate unit to 100 parts by weight of a polyvinyl chloride resin, wherein number-average molecular weight of the (meth)acrylate copolymer is 7,000 to 50,000.
    Type: Application
    Filed: September 19, 2013
    Publication date: July 9, 2015
    Applicant: TOYOBO CO., LTD.
    Inventors: Yuta Kawakatsu, Yoshiaki Karato, Tomoya Ohashi, Susumu Kashiwabara
  • Patent number: 9017714
    Abstract: A nerve regeneration-inducing tube is provided which is excellent in cell growth property, resistance to pressure, shape recovery property, and anti-kink property in a nerve regeneration-inducing tube where a collagen solution is applied on the outer surface of a tubular body woven with ultrafine fiber comprising biodegradable and bioabsorbable polymer while collagen is filled in the inner area of the tubular body. The nerve regeneration-inducing tube has a degradation speed which is adjusted so as to make it suitable for the connection of nerve gaps of more than 40 mm. The nerve regeneration-inducing tube includes collagen coated on the outer surface of a tubular body woven with fiber bundles where plural ultrafine fibers comprising a biodegradable and bioabsorbable polymer are bundled. The tubular body mostly comprises a first polymer which is biodegradable and bioabsorbable and a second polymer which has higher biodegradability and bioabsorbability than those of the first polymer.
    Type: Grant
    Filed: December 25, 2008
    Date of Patent: April 28, 2015
    Assignee: Toyo Boseki Kabushiki Kaisha
    Inventors: Fumihiko Kajii, Hidenori Tanaka, Susumu Kashiwabara, Yuta Kawakatsu
  • Patent number: 8916225
    Abstract: The present invention provides a method for coating an inner surface of a polyvinyl chloride medical tube containing a plasticizer with an antithrombogenic material composed of a specific (meth)acrylate copolymer. The simple method of the present invention is capable of evenly and efficiently coating an inner surface of a polyvinyl chloride medical tube with a sufficient amount of an antithrombogenic material without causing appearance deterioration or uneven coating due to elution of the plasticizer. The method is performed by passing through a tube a solution that is prepared by dissolving an antithrombogenic material in a solvent composed of water and at least one alcohol that is adjusted to dissolve the copolymer of the antithrombogenic material but does not dissolve the plasticizer, then subsequently passing water through the tube, and finally drying the tube.
    Type: Grant
    Filed: January 6, 2011
    Date of Patent: December 23, 2014
    Assignee: Toyo Boseki Kabushiki Kaisha
    Inventors: Fumihiko Kajii, Hidenori Tanaka, Susumu Kashiwabara
  • Patent number: 8741328
    Abstract: The present invention provides a nerve regeneration-inducing tube in which collagen having excellent adhesive property, cell growth property and differentiation inducing property to nerve cells is used as a scaffold for the nerve regeneration. The nerve regeneration-inducing tube is characterized in using the collagen which is made the concentration of sodium chloride contained therein not more than 2.0% by weight or, preferably, 0.1 to 1.5% by weight in a dry state. Purification of collagen is carried out by means of an isoelectric precipitation where the pH is 6.0 or higher and is lower than 10.0.
    Type: Grant
    Filed: February 2, 2009
    Date of Patent: June 3, 2014
    Assignee: Toyo Boseki Kabushiki Kaisha
    Inventors: Michiko Suzuki, Fumihiko Kajii, Hidenori Tanaka, Susumu Kashiwabara
  • Publication number: 20140100591
    Abstract: A method for manufacturing a nerve regeneration-inducing tube with excellent pressure resistance, shape recovery property, anti-kink property, film exfoliation resistance, resistance to invasion of outer tissues, and leakage resistance. The tubular body is formed by weaving together fibers made up of biodegradable polymer. The outer surface of the tubular body is coated multiple times with a collagen solution. The lumen of the tubular body is filled with collagen. Viscosity of the collagen solution that is first applied to the outer surface of the tubular body is between 2 to 800 cps. Viscosity of the collagen solution that is subsequently applied is higher than viscosity of the first applied collagen solution.
    Type: Application
    Filed: December 13, 2013
    Publication date: April 10, 2014
    Applicant: TOYO BOSEKI KABUSHIKI KAISHA
    Inventors: Fumihiko Kajii, Hidenori Tanaka, Yuta Kawakatsu, Susumu Kashiwabara, Masaki Sato
  • Publication number: 20140099427
    Abstract: A method for manufacturing a nerve regeneration-inducing tube with excellent pressure resistance, shape recovery property, anti-kink property, film exfoliation resistance, resistance to invasion of outer tissues, and leakage resistance. The tubular body is formed by weaving together fibers made up of biodegradable polymer. The outer surface of the tubular body is coated multiple times with a collagen solution. The lumen of the tubular body is filled with collagen. Viscosity of the collagen solution that is first applied to the outer surface of the tubular body is between 2 to 800 cps. Viscosity of the collagen solution that is subsequently applied is higher than viscosity of the first applied collagen solution.
    Type: Application
    Filed: December 13, 2013
    Publication date: April 10, 2014
    Applicant: TOYO BOSEKI KABUSHIKI KAISHA
    Inventors: Fumihiko Kajii, Hidenori Tanaka, Yuta Kawakatsu, Susumu Kashiwabara, Masaki Sato
  • Patent number: 8632844
    Abstract: A method for manufacturing a nerve regeneration-inducing tube with excellent pressure resistance, shape recovery property, anti-kink property, film exfoliation resistance, resistance to invasion of outer tissues, and leakage resistance. The tubular body is formed by weaving together fibers made up of biodegradable polymer. The outer surface of the tubular body is coated multiple times with a collagen solution. The lumen of the tubular body is filled with collagen. Viscosity of the collagen solution that is first applied to the outer surface of the tubular body is between 2 to 800 cps. Viscosity of the collagen solution that is subsequently applied is higher than viscosity of the first applied collagen solution.
    Type: Grant
    Filed: December 4, 2008
    Date of Patent: January 21, 2014
    Assignee: Toyo Boseki Kabushiki Kaisha
    Inventors: Fumihiko Kajii, Hidenori Tanaka, Yuta Kawakatsu, Susumu Kashiwabara, Masaki Sato
  • Publication number: 20120283665
    Abstract: The present invention provides a method for coating an inner surface of a polyvinyl chloride medical tube containing a plasticizer with an antithrombogenic material composed of a specific (meth)acrylate copolymer. The simple method of the present invention is capable of evenly and efficiently coating an inner surface of a polyvinyl chloride medical tube with a sufficient amount of an antithrombogenic material without causing appearance deterioration or uneven coating due to elution of the plasticizer. The method is performed by passing through a tube a solution that is prepared by dissolving an antithrombogenic material in a solvent composed of water and at least one alcohol that is adjusted to dissolve the copolymer of the antithrombogenic material but does not dissolve the plasticizer, then subsequently passing water through the tube, and finally drying the tube.
    Type: Application
    Filed: January 6, 2011
    Publication date: November 8, 2012
    Applicant: TOYO BOSEKI KABUSHIKI KAISHA
    Inventors: Fumihiko Kajii, Hidenori Tanaka, Susumu Kashiwabara
  • Patent number: 8236913
    Abstract: [Object] An object of the present invention is to provide a surface-treating agent excellent in antithrombogenicity, and accordingly, excellent in biocompatibility, and having high hydrophilicity as compared with conventional medical materials. Further, an object of the present invention is to provide a production method excellent in performance of removing unreacted monomers and further improving a yield as compared with conventional production methods. [Constitution] The present invention relates to a water-insoluble copolymer comprising alkyl(meth)acrylate and methoxypolyethylene glycol(meth)acrylate. The present invention also relates to a method for producing a water-insoluble (meth)acrylate copolymer by copolymerizing alkyl(meth)acrylate and methoxypolyethylene glycol(meth)acrylate in a common polymerization solvent.
    Type: Grant
    Filed: December 7, 2006
    Date of Patent: August 7, 2012
    Assignee: Toyo Boseki Kabushiki Kaisha
    Inventors: Yuta Kawakatsu, Susumu Kashiwabara
  • Patent number: 8142717
    Abstract: The invention provides an oxygenator of a hollow fiber membrane type where a plurality of hollow fiber membranes are received in a housing, wherein at least a part of the regions of the hollow fiber membranes to contact blood during use is coated with a water-insoluble (meth)acrylate copolymer in which a hydrophobic (meth)acrylate is copolymerized with a hydrophilic (meth)acrylate at a molar ratio of (50 to 90):(50 to 10).
    Type: Grant
    Filed: April 21, 2008
    Date of Patent: March 27, 2012
    Assignee: Toyo Boseki Kabushiki Kaisha
    Inventors: Yuta Kawakatsu, Hidenori Tanaka, Susumu Kashiwabara
  • Publication number: 20110288569
    Abstract: The present invention provides a nerve regeneration-inducing tube in which collagen having excellent adhesive property, cell growth property and differentiation inducing property to nerve cells is used as a scaffold for the nerve regeneration. The nerve regeneration-inducing tube is characterized in using the collagen which is made the concentration of sodium chloride contained therein not more than 2.0% by weight or, preferably, 0.1 to 1.5% by weight in a dry state. Purification of collagen is carried out by means of an isoelectric precipitation where the pH is 6.0 or higher and is lower than 10.0.
    Type: Application
    Filed: February 2, 2009
    Publication date: November 24, 2011
    Applicant: TOYO BOSEKI KABUSHIKI KAISHA
    Inventors: Michiko Suzuki, Fumihiko Kajii, Hidenori Tanaka, Susumu Kashiwabara
  • Publication number: 20100255060
    Abstract: To provide a nerve regeneration-inducing tube being excellent in cell growth property, resistance to pressure, shape recovery property, and anti-kink property in a nerve regeneration-inducing tube where a collagen solution is applied on the outer surface of a tubular body knitted with ultrafine fiber comprising biodegradable and bioabsorbable polymer while collagen is filled in the inner area of the tubular body. Specifically, to provide a nerve regeneration-inducing tube where a degradation speed is adjusted so as to make it suitable for the connection of nerve gaps of more than 40 mm.
    Type: Application
    Filed: December 25, 2008
    Publication date: October 7, 2010
    Applicant: TOYO BOSEKI KABUSHIKI KAISHA
    Inventors: Fumihiko Kajii, Hidenori Tanaka, Susumu Kashiwabara, Yuta Kawakatsu
  • Publication number: 20100249811
    Abstract: To provide a method for the manufacture of a nerve regeneration-inducing tube being excellent in pressure resistance, shape recovery property, anti-kink property, film exfoliation resistance, property of prevention of invasion of outer tissues and leakage resistance. The present invention is a method for the manufacture of a nerve regeneration-inducting tube in which the outer surface of the tubular body knitted with a plurality of ultrafine fibers comprising biodegradable polymer is coated by application of a collagen solution for plural times to coat and then collagen is filled in the inner area of the above tubular body, characterized in that, viscosity of the collagen solution which is firstly applied on the outer surface of the tubular body is made 2 cps to 800 cps or, preferably, 5 cps to 200 cps. Preferably, viscosity of a collagen solution to be applied later is made high as compared with that of the firstly-applied one.
    Type: Application
    Filed: December 4, 2008
    Publication date: September 30, 2010
    Applicant: TOYO BOSEKI KABUSHIKI KAISHA
    Inventors: Fumihiko Kajii, Hidenori Tanaka, Yuta Kawakatsu, Susumu Kashiwabara, Masaki Sato
  • Publication number: 20100135852
    Abstract: The invention provides an oxygenator of a hollow fiber membrane type where a plurality of hollow fiber membranes are received in a housing, wherein at least a part of the regions of the hollow fiber membranes to contact blood during use is coated with a water-insoluble (meth)acrylate copolymer in which a hydrophobic (meth)acrylate is copolymerized with a hydrophilic (meth)acrylate at a molar ratio of (50 to 90):(50 to 10).
    Type: Application
    Filed: April 21, 2008
    Publication date: June 3, 2010
    Applicant: TOYO BOSEKI KABUSHIKI KAISHA
    Inventors: Yuta Kawakatsu, Hidenori Tanaka, Susumu Kashiwabara
  • Publication number: 20100069595
    Abstract: [Object] An object of the present invention is to provide a surface-treating agent excellent in antithrombogenicity, and accordingly, excellent in biocompatibility, and having high hydrophilicity as compared with conventional medical materials. Further, an object of the present invention is to provide a production method excellent in performance of removing unreacted monomers and further improving a yield as compared with conventional production methods. [Constitution] The present invention relates to a water-insoluble copolymer comprising alkyl(meth)acrylate and methoxypolyethylene glycol(meth)acrylate. The present invention also relates to a method for producing a water-insoluble (meth)acrylate copolymer by copolymerizing alkyl(meth)acrylate and methoxypolyethylene glycol(meth)acrylate in a common polymerization solvent.
    Type: Application
    Filed: December 7, 2006
    Publication date: March 18, 2010
    Applicant: TOYO BOSEKI KABUSHIKI KAISHA
    Inventors: Yuta Kawakatsu, Susumu Kashiwabara
  • Patent number: 6967003
    Abstract: A membrane artificial lung performs gas exchange between blood and a gas via the membrane by flowing the blood in one side of the membrane and flowing oxygen or an oxygen-containing gas in the other side of the membrane. The membrane has a hollow fiber membrane of poly-4-methylpentene-1 and an oxygen permeation rate Q(O2) at 25° C. of from 1×10?6 to 3×10?3 (cm3(STP)/cm2·sec·cmHg) and an ethanol flux of from 0.1 to 100 ml/min·m2. The membrane has, in the side of the blood flow, a surface having an ionic complex derived from: quaternary aliphatic alkylammonium salts; and heparin or a heparin derivative. The quaternary alkylammonium salts are a quaternary aliphatic alkylammonium salt having from 22 to 26 carbon atoms in total and a quaternary aliphatic alkylammonium salt having from 37 to 40 carbon atoms in total.
    Type: Grant
    Filed: September 28, 2001
    Date of Patent: November 22, 2005
    Assignees: Dainippon Ink and Chemicals, Inc., Toyo Boseki Kabushiki Kaisha
    Inventors: Toru Takehisa, Kazunari Sakai, Susumu Kashiwabara, Hidenori Tanaka, Masaki Satoh, Hisateru Takano, Yoshiyuki Taenaka, Eisuke Tatsumi, Tomohiro Nishinaka
  • Publication number: 20040213818
    Abstract: The present invention provides an antithrombotic composition containing an ionic complex formed from an organic cation mixture and heparin or a heparin derivative, wherein the organic cation mixture is a mixture of at least two ammonium salts, provided that the above-mentioned organic cation mixture is not a mixture of a didodecyldimethylammonium salt and at least one kind of an ammonium salt selected from ammonium salts having four aliphatic groups, wherein the four aliphatic groups have 30 to 38 carbon atoms in total and at least two of the four aliphatic groups are each an alkyl group having not less than 10 carbon atoms. This antithrombotic composition can impart superior antithrombotic property to a medical device over a prolonged period.
    Type: Application
    Filed: April 26, 2004
    Publication date: October 28, 2004
    Inventors: Susumu Kashiwabara, Hidenori Tanaka, Masaki Sato
  • Publication number: 20030064003
    Abstract: A membrane artificial lung for performing gas exchange between blood and a gas via the membrane by flowing the blood in one side of the membrane and flowing oxygen or an oxygen-containing gas in the other side of the membrane, wherein said membrane comprises a hollow fiber membrane, said hollow fiber membrane comprising poly-4-methylpentene-1 and having an oxygen permeation rate Q(O2) at 25° C. of from 1×10−6 to 3×10−3 (cm3(STP)/cm2·sec·cmHg) and an ethanol flux of from 0.1 to 100 ml/min·m2, wherein said membrane has, in the side of the blood flow, a surface comprising an ionic complex derived from: quaternary aliphatic alkylammonium salts; and heparin or a heparin derivative, and wherein said quaternary alkylammonium salts comprise a quaternary aliphatic alkylammonium salt having from 22 to 26 carbon atoms in total and a quaternary aliphatic alkylammonium salt having from 37 to 40 carbon atoms in total.
    Type: Application
    Filed: September 28, 2001
    Publication date: April 3, 2003
    Inventors: Toru Takehisa, Kazunari Sakai, Susumu Kashiwabara, Hidenori Tanaka, Masaki Satoh, Hisateru Takano, Yoshiyuki Taenaka, Eisuke Tatsumi, Tomohiro Nishinaka
  • Publication number: 20010016611
    Abstract: The present invention provides an antithrombogenic composition containing an ionic complex of ammonium salts and heparin or a heparin derivative, the ammonium salts each comprising four aliphatic alkyl groups bonded thereto, wherein an ammonium salt containing four aliphatic alkyl groups having not less than 22 and not more than 26 carbon atoms in total is contained in an amount of not less than 5% and not more than 80% of the total ammonium salt by weight, which is capable of maintaining sufficient antithrombogenicity for a long time, and a medical device coated with the antithrombogenic composition.
    Type: Application
    Filed: January 26, 2001
    Publication date: August 23, 2001
    Inventors: Susumu Kashiwabara, Hidenori Tanaka, Masaki Sato