Abstract: An object of the present invention is to provide an anti-tumor agent that exhibits a remarkably excellent anti-tumor effect. According to the present invention, there is provided an anti-tumor agent for curing cancer, the anti-tumor agent having a liposome which has an inner water phase and having an aqueous solution which is an outer water phase and disperses the liposome, in which the liposome encompasses topotecan or a salt thereof, a lipid constituting the liposome contains a lipid modified with polyethylene glycol, dihydrosphingomyelin, and cholesterol, the inner water phase contains an ammonium salt, and the topotecan or the salt thereof encompassed in the liposome is administered at a dose rate of 0.1 mg/m2 body surface area to 10 mg/m2 body surface area, in terms of topotecan per administration.

Abstract: An object of the present invention is to provide a treatment agent for Merkel cell cancer. According to the present invention, there is provided a treatment agent for Merkel cell cancer, having a liposome which has an inner water phase and having an aqueous solution which is an outer water phase and disperses the liposome, in which the liposome encompasses topotecan or a salt thereof, a lipid constituting the liposome contains a lipid modified with polyethylene glycol, dihydrosphingomyelin, and cholesterol, and the inner water phase contains an ammonium salt.

Abstract: An embodiment in accordance with the present invention provides a system and method for a three-dimensional interface for interacting with a database. The three-dimensional interface can include an interactive three-dimensional atlas depicting an element of anatomy, machine, device, or other object. Given the three-dimensional nature of the atlas, a user can zoom in on particular areas to view them with more specificity. Different structural points of the anatomy are labeled with names or coordinates, such that the user can select one of the structural points and search a database for information related to that specific structural point. The user can also use specific keywords to search with respect to the specific structural point selected. The three-dimensional interface and atlas are displayed to the user on a computing device that can either house the database within its memory or alternately communicate with the database over a network.

Abstract: An asphalt modifier comprising a polyolefin-based copolymer comprising an ethylene-derived monomer unit and a monomer unit having an epoxy group is disclosed. The content of the monomer unit having an epoxy group is 13% by mass or more based on the mass of the polyolefin-based copolymer.

Abstract: A non-invasive imaging system, including an imaging scanner suitable to generate an imaging signal from a tissue region of a subject under observation, the tissue region having at least one substructure; a signal processing system in communication with the imaging scanner to receive the imaging signal from the imaging scanner; and a data storage unit in communication with the signal processing system, wherein the data storage unit stores an anatomical atlas comprising data encoding spatial information of the at least one substructure in the tissue region, and a pathological atlas corresponding to an abnormality of the tissue region, wherein the signal processing system is adapted to automatically identify, using the imaging signal, the anatomical atlas, and the pathological atlas, a presence of the abnormality or a pre-cursor abnormality in the subject under observation.

Abstract: A computer-implemented method, a computer system and a non-transitory computer-readable medium for constructing human-readable sentences from imaging data of a subject can include: receiving imaging data including image elements of at least one region of interest of the subject; segmenting the imaging data of the region of interest into a plurality of sub-regions, where each sub-region includes a portion of the image elements; calculating an abnormality factor for each of the sub-regions by quantitatively analyzing segmented image information of the imaging data of the sub-regions using data from a normal database; comparing each abnormality factor to a threshold value; constructing a human-understandable sentence for the subject when a corresponding abnormality factor exceeds the threshold, where each human-understandable sentence references a physical structure threshold associated with the calculation for the region or sub-region; and outputting the human-understandable sentences for the at least one regio

Abstract: An asphalt modifier comprising a polyolefin-based copolymer comprising an ethylene-derived monomer unit and a monomer unit having an epoxy group is disclosed. The content of the monomer unit having an epoxy group is 13% by mass or more based on the mass of the polyolefin-based copolymer.

Abstract: An optical apparatus includes a first optical element and a second optical element capable of separating incident light according to a wavelength of the incident light. The first optical element includes a first separation section having first optical characteristics for reflecting light in a first wavelength band, transmitting light in a second wavelength band, and partially transmitting and partially reflecting light in a third wavelength band. The second optical element includes a second separation section having second optical characteristics for separating incident light that is incident in two wavelength bands including the first wavelength band or the second wavelength band and the third wavelength band into the light in the first wavelength band or the light in the second wavelength band and the light in the third wavelength band according to the wavelength.

Abstract: A computer-implemented method, system and non-transitory computer readable storage medium for classifying a region of interest of a subject, including receiving imaging data comprising at least one image element, the imaging data comprising the region of interest of the subject; providing a plurality of atlases, each of the plurality of atlases having a candidate region that corresponds to the region of interest of the imaging data, each of the plurality of atlases having at least one image element with associated location and property information; co-registering the plurality of atlases to the imaging data, using at least one processor; assigning a probability to generate a labeling parameter for the region of interest, the probability being associated with each atlas; and classifying the region of interest of the subject based on the assigning.

Abstract: To produce both 2D image data and color parallax image data from image data output from a single-plate image sensor, the resolutions of the 2D image data and parallax image data may be both degraded. The image sensor has a primitive lattice that is a group of pixels including (i) at least four types of parallax pixels formed by photoelectric converter elements each of which is associated with one of combinations of two different types of aperture masks and two different types of color filters and (ii) no-parallax pixels configured to guide an incident luminous flux to photoelectric converter elements without limitation. In the group of pixels, the no-parallax pixels are more than the parallax pixels.

Abstract: Computer systems, computer-implemented methods, and non-transitory computer readable storage media for gross feature recognition including receiving an image comprising a plurality of image elements representing the region of interest of the subject. Gross feature recognition can further include co-registering the image to an atlas to segment the plurality of image elements into a plurality of sub-regions corresponding to structures in the atlas, where the structures in the atlas are ordered in a first rank order according to a predetermined feature. Further included can be ordering the plurality of sub-regions in a second rank order according to the predetermined feature. Further included can be identifying as gross features one or more of the plurality of sub-regions whose positions in the first rank order of the ordered sub-regions differ from positions in the second rank order of the corresponding ordered structures in the atlas.

Abstract: A computer-implemented method, a computer system and a non-transitory computer-readable medium for constructing human-readable sentences from imaging data of a subject can include: receiving imaging data including image elements of at least one region of interest of the subject; segmenting the imaging data of the region of interest into a plurality of sub-regions, where each sub-region includes a portion of the image elements; calculating an abnormality factor for each of the sub-regions by quantitatively analyzing segmented image information of the imaging data of the sub-regions using data from a normal database; comparing each abnormality factor to a threshold value; constructing a human-understandable sentence for the subject when a corresponding abnormality factor exceeds the threshold, where each human-understandable sentence references a physical structure threshold associated with the calculation for the region or sub-region; and outputting the human-understandable sentences for the at least one regio

Abstract: A method, computer system and computer readable storage medium for searching for one or more images having a region of interest similar to the region of a subject, including: receiving imaging data comprising a plurality of image elements of the region of interest of the subject; segmenting the imaging data of the region of interest of the subject into a plurality of sub-regions corresponding to various structures at a plurality of levels of granularity, the plurality of levels of granularity having a relationship such that a level of granularity has fewer structures at a lower level of granularity; and calculating at each of the plurality of levels of granularity an abnormality factor or risk factor for the segmented various structures of said region of interest, to provide a segmented said region of interest of said subject with at least one of said abnormality factor or risk factor associated therewith.

Abstract: A technique is disclosed to obtain first image data including a first pixel value of a first pixel having a no-parallax opening corresponding to a reference direction, a second pixel value of a second pixel having a parallax opening that causes parallax in one direction and a third pixel value of a third pixel having a parallax opening that causes parallax in the opposite direction, to calculate, for a pixel position of the second pixel, a fourth pixel value by averaging the second pixel value at the pixel position and a hypothetical third pixel value and to calculate, for a pixel position of the third pixel, a fifth pixel value by averaging the third pixel value at the pixel position and a hypothetical second pixel value, and to use the first pixel value, the fourth pixel value and the fifth pixel value to produce 2D second image data.

Abstract: To produce both 2D image data and color parallax image data from image data output from a single-plate image sensor, the resolutions of the 2D image data and parallax image data may be both degraded. The image sensor has a primitive lattice that is a group of pixels including (i) at least four types of parallax pixels formed by photoelectric converter elements each of which is associated with one of combinations of two different types of aperture masks and two different types of color filters and (ii) no-parallax pixels configured to guide an incident luminous flux to photoelectric converter elements without limitation. In the group of pixels, the no-parallax pixels are more than the parallax pixels.

Abstract: To produce both 2D image data and color parallax image data from image data output from a single-plate image sensor, the resolutions of the 2D image data and parallax image data may be both degraded. The image sensor has a primitive lattice that is a group of pixels including (i) at least four types of parallax pixels formed by photoelectric converter elements each of which is associated with one of combinations of two different types of aperture masks and two different types of color filters and (ii) no-parallax pixels configured to guide an incident luminous flux to photoelectric converter elements without limitation. In the group of pixels, the no-parallax pixels are more than the parallax pixels.

Abstract: With a conventional stereoimage capturing device, it has been difficult to simply determine the present of a depth. An image capturing device includes an image capturing element in which a first parallax pixel group and a second parallax pixel group that output a first parallax image and a second parallax image, respectively, to cause a parallax are arranged at mutually different positions. The image capturing device computes a differential pixel value of each of a plurality of second parallax output pixels in the second parallax image positioned around a target pixel that is a first parallax output pixel of the first parallax image, the differential pixel value being computed with reference to the target pixel, and generates differential data in which a direction of each of the plurality of second parallax output pixels with reference to the target pixel is associated with the corresponding differential pixel value.

Abstract: So as to obtain color parallax images, it has been necessary to prepare an image capturing optical system and an image capturing element that are complex, to capture the parallax images. In view of this, provided is an image processing apparatus including: an image obtaining section that obtains original image data including a pixel having a pixel value of any of primary colors constituting colors of a subject image and a pixel having a pixel value showing at least a parallax of the subject image; and an image generating section that generates, from the original image data, primary color image data made up of pixels having the pixel value of the primary color, and parallax image data made up of pixels having the pixel value showing the parallax.

Abstract: Images can be processed using an image processing apparatus including: an image data obtaining section that obtains at least two pieces of parallax image data from an image capturing element that includes color filters and opening masks so that one color filter and one opening mask correspond to one of at least a part of photoelectric conversion elements and outputs the at least two pieces of parallax image data; and a correcting section that corrects color imbalance of a corresponding pixel caused between the at least two pieces of parallax image data, based on at least one of a position of the at least a part of photoelectric conversion elements in the image capturing element and an opening displacement of the opening mask.

Abstract: The present invention is directed to a context-based image retrieval (CBIR) system for disease estimation based on the multi-atlas framework, in which the demographic and diagnostic information of multiple atlases are weighted and fused to generate an estimated diagnosis, on a structure-by-structure basis. The present invention demonstrates high accuracy in age estimation, as well as diagnostic estimation in Alzheimer's disease. The system and the pathology-based multi atlases can be used to estimate various types of disease and pathology with the choice of patient attributes. The present invention is also directed to a method of context-based image retrieval.