Abstract: The GmLMM1 gene, which is involved in the regulation of PTI immune responses, Phytophthora resistance, bacterial blight of soybean disease, soybean halo disease, etc., is cloned in soybeans. The PTI immune response and pathogen resistance of plants can be negatively regulated via the GmLMM1 gene. By reducing the expression of GmLMM1, the PTI immune response of plants can be effectively enhanced, and the pathogen resistance of plants can be increased. Cloning and functional discovery of the GmLMM1 gene provide important foundations and theoretical support for research on the related mechanisms of soybean disease resistance and provide valuable genetic resources for advancing the research and application of plant defense systems. Additionally, cloning and functional delivery of the GmLMM1 gene allows for breeding new soybean varieties with high disease resistance.

Abstract: The present disclosure provides a Tripterygium wilfordii composition for inhibiting a drug-resistant cancer. The composition is prepared by triptolide (TP) with any one or two compounds selected from the group consisting of 1?-(E-cinnamoyloxy)-4a-hydroxy-5a,7?,11-triacetoxy-8?-nicotinoyloxy-dihydroagarofuran, Demethylzeylasteral, Triptobenzene R, (3S,4S,5R,10S)-3,19-dihydroxy-7-ox-oabieta-8,11,13-triene, and Triptobenzene B. In the present disclosure, the composition has a lower toxicity and an enhanced drug effect for inhibiting proliferation of drug-resistant tumor cells than those of the TP. Compared with the single TP, the composition has an effect of attenuation and synergia.

Abstract: The GmLMM1 gene, which is involved in the regulation of PTI immune responses, Phytophthora resistance, bacterial blight of soybean disease, soybean halo disease, etc., is cloned in soybeans. The PTI immune response and pathogen resistance of plants can be negatively regulated via the GmLMM1 gene. By reducing the expression of GmLMM1, the PTI immune response of plants can be effectively enhanced, and the pathogen resistance of plants can be increased. Cloning and functional discovery of the GmLMM1 gene provide important foundations and theoretical support for research on the related mechanisms of soybean disease resistance and provide valuable genetic resources for advancing the research and application of plant defense systems. Additionally, cloning and functional delivery of the GmLMM1 gene allows for breeding new soybean varieties with high disease resistance.