Patents by Inventor Suyambu Kesava Vijayan RAMASWAMY

Suyambu Kesava Vijayan RAMASWAMY has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of receptor interacting protein kinase I for the treatment of disease
    Patent number: 11753381
    Abstract: Disclosed herein are compounds which inhibit RIPK1, pharmaceutical compositions, and methods of treatment of RIPK1-mediated diseases, such as neurodegenerative disorders, inflammatory disorders, and cancer.
    Type: Grant
    Filed: September 25, 2020
    Date of Patent: September 12, 2023
    Assignee: Board of Regents, The University of Texas System
    Inventors: Richard T. Lewis, Matthew Michael Hamilton, William J. Ray, Fernando Alvarez, Dana E. Pfaffinger, Naphtali Reyna, Jason Cross, Suyambu Kesava Vijayan Ramaswamy
  • Inhibitors of receptor interacting protein kinase I for the treatment of disease
    Patent number: 11718612
    Abstract: Disclosed herein are compounds which inhibit RIPK1, pharmaceutical compositions, and methods of treatment of RIPK1-mediated diseases, such as neurodegenerative disorders, inflammatory disorders, and cancer.
    Type: Grant
    Filed: September 8, 2020
    Date of Patent: August 8, 2023
    Assignee: Board of Regents, The University of Texas System
    Inventors: Richard T. Lewis, Matthew Hamilton, William J. Ray, Fernando Alvarez, Naphtali Reyna, Jason Cross, Suyambu Kesava Vijayan Ramaswamy
  • Inhibitors of receptor interacting protein kinase I for the treatment of disease
    Patent number: 11690850
    Abstract: Disclosed herein are compounds which inhibit RIPK1, pharmaceutical compositions, and methods of treatment of RIPK1-mediated diseases, such as neurodegenerative disorders, inflammatory disorders, and cancer.
    Type: Grant
    Filed: November 19, 2020
    Date of Patent: July 4, 2023
    Assignee: Board of Regents, The University of Texas System
    Inventors: Richard T. Lewis, Matthew Hamilton, William J. Ray, Fernando Alvarez, Naphtali Reyna, Jason Cross, Suyambu Kesava Vijayan Ramaswamy
  • INHIBITORS OF RECEPTOR INTERACTING PROTEIN KINASE I FOR THE TREATMENT OF DISEASE
    Publication number: 20230159508
    Abstract: Disclosed herein are compounds which inhibit RIPK1, pharmaceutical compositions, and methods of treatment of RIPK1-mediated diseases, such as neurodegenerative disorders, inflammatory disorders, and cancer.
    Type: Application
    Filed: August 17, 2022
    Publication date: May 25, 2023
    Inventors: Richard T. LEWIS, Matthew HAMILTON, William J. RAY, Fernando ALVAREZ, Naphtali REYNA, Suyambu Kesava Vijayan RAMASWAMY
  • Methods for the design of mechanism-based sirtuin activating compounds
    Patent number: 11459597
    Abstract: The instant invention provides workflows for the design and characterization of mechanism-based sirtuin modulating compounds, including new or improved sirtuin activating compounds. Workflows for the design of mechanism-based sirtuin activating compounds are provided, based on conditions that must be satisfied by activators if they are to exploit the common catalytic mechanism of all sirtuin enzymes and hence increase catalytic efficiency for any sirtuin and any substrate.
    Type: Grant
    Filed: September 14, 2016
    Date of Patent: October 4, 2022
    Assignee: CHAKRABARTI ADVANCED TECHNOLOGY LLC
    Inventors: Raj Chakrabarti, Alok Upadhyay, Sudipto Munshi, Suyambu Kesava Vijayan Ramaswamy, Xiangying Guan
  • Heterocyclic inhibitors of ATR kinase
    Patent number: 11434233
    Abstract: The present disclosure relates to heterocyclic compounds and methods which may be useful as inhibitors of ATR kinase for the treatment or prevention of cancer.
    Type: Grant
    Filed: September 1, 2020
    Date of Patent: September 6, 2022
    Assignees: Board of Regents, The University of Texas System, ChemPartner Corporation
    Inventors: Maria Emilia Di Francesco, Philip Jones, Christopher Lawrence Carroll, Jason Bryant Cross, Suyambu Kesava Vijayan Ramaswamy, Michael Garrett Johnson, Sarah Lively, David Lapointe
  • Methods for the design of mechanism-based sirtuin activating compounds
    Patent number: 11118211
    Abstract: The instant invention provides workflows for the design and characterization of mechanism-based sirtuin modulating compounds, including new or improved sirtuin activating compounds. Workflows for the design of mechanism-based sirtuin activating compounds are provided, based on conditions that must be satisfied by activators if they are to exploit the common catalytic mechanism of all sirtuin enzymes and hence increase catalytic efficiency for any sirtuin and any substrate.
    Type: Grant
    Filed: August 6, 2020
    Date of Patent: September 14, 2021
    Assignee: CHAKRABARTI ADVANCED TECHNOLOGY LLC
    Inventors: Raj Chakrabarti, Alok Upadhyay, Sudipto Munshi, Suyambu Kesava Vijayan Ramaswamy, Xiangying Guan
  • INHIBITORS OF RECEPTOR INTERACTING PROTEIN KINASE I FOR THE TREATMENT OF DISEASE
    Publication number: 20210154204
    Abstract: Disclosed herein are compounds which inhibit RIPK1, pharmaceutical compositions, and methods of treatment of RIPK1-mediated diseases, such as neurodegenerative disorders, inflammatory disorders, and cancer.
    Type: Application
    Filed: November 19, 2020
    Publication date: May 27, 2021
    Inventors: Richard T. LEWIS, Matthew HAMILTON, William J. RAY, Fernando ALVAREZ, Naphtali REYNA, Jason CROSS, Suyambu Kesava Vijayan RAMASWAMY
  • INHIBITORS OF RECEPTOR INTERACTING PROTEIN KINASE I FOR THE TREATMENT OF DISEASE
    Publication number: 20210094951
    Abstract: Disclosed herein are compounds which inhibit RIPK1, pharmaceutical compositions, and methods of treatment of RIPK1-mediated diseases, such as neurodegenerative disorders, inflammatory disorders, and cancer.
    Type: Application
    Filed: September 8, 2020
    Publication date: April 1, 2021
    Inventors: Richard T. LEWIS, Matthew HAMILTON, William J. RAY, Fernando ALVAREZ, Naphtali REYNA, Jason CROSS, Suyambu Kesava Vijayan RAMASWAMY
  • INHIBITORS OF RECEPTOR INTERACTING PROTEIN KINASE I FOR THE TREATMENT OF DISEASE
    Publication number: 20210094921
    Abstract: Disclosed herein are compounds which inhibit RIPK1, pharmaceutical compositions, and methods of treatment of RIPK1-mediated diseases, such as neurodegenerative disorders, inflammatory disorders, and cancer.
    Type: Application
    Filed: September 25, 2020
    Publication date: April 1, 2021
    Inventors: Richard T. LEWIS, Matthew Michael HAMILTON, William J. RAY, Fernando ALVAREZ, Dana E. PFAFFINGER, Naphtali REYNA, Jason CROSS, Suyambu Kesava Vijayan RAMASWAMY, Nicole A. RICHARDS
  • HETEROCYCLIC INHIBITORS OF ATR KINASE
    Publication number: 20210047311
    Abstract: The present disclosure relates to heterocyclic compounds and methods which may be useful as inhibitors of ATR kinase for the treatment or prevention of cancer.
    Type: Application
    Filed: September 1, 2020
    Publication date: February 18, 2021
    Inventors: Maria Emilia DI FRANCESCO, Philip JONES, Christopher Lawrence CARROLL, Jason Bryant CROSS, Suyambu Kesava Vijayan RAMASWAMY, Michael Garrett JOHNSON, Sarah LIVELY, David LAPOINTE
  • Heterocyclic inhibitors of ATR kinase
    Patent number: 10894052
    Abstract: The present disclosure relates to heterocyclic compounds and methods which inhibit ATR kinase to treat or prevent cancer.
    Type: Grant
    Filed: March 18, 2019
    Date of Patent: January 19, 2021
    Assignees: Board of Regents, The University of Texas System, ChemPartner Corporation
    Inventors: Maria Emilia Di Francesco, Philip Jones, Christopher Lawrence Carroll, Suyambu Kesava Vijayan Ramaswamy, Zhijun Kang, Michael Garrett Johnson, Sarah Lively, David Lapointe
  • METHODS FOR THE DESIGN OF MECHANISM-BASED SIRTUIN ACTIVATING COMPOUNDS
    Publication number: 20200370089
    Abstract: The instant invention provides workflows for the design and characterization of mechanism-based sirtuin modulating compounds, including new or improved sirtuin activating compounds. Workflows for the design of mechanism-based sirtuin activating compounds are provided, based on conditions that must be satisfied by activators if they are to exploit the common catalytic mechanism of all sirtuin enzymes and hence increase catalytic efficiency for any sirtuin and any substrate.
    Type: Application
    Filed: August 6, 2020
    Publication date: November 26, 2020
    Inventors: Raj CHAKRABARTI, Alok Upadhyay, Sudipto Munshi, Suyambu Kesava Vijayan Ramaswamy, Xiangying Guan
  • Heterocyclic inhibitors of ATR kinase
    Patent number: 10800769
    Abstract: The present disclosure relates to heterocyclic compounds and methods which may be useful as inhibitors of ATR kinase for the treatment or prevention of cancer.
    Type: Grant
    Filed: July 10, 2019
    Date of Patent: October 13, 2020
    Assignees: Board of Regents, The University of Texas System, ChemPartner Corporation
    Inventors: Maria Emilia Di Francesco, Philip Jones, Christopher Lawrence Carroll, Jason Bryant Cross, Suyambu Kesava Vijayan Ramaswamy, Michael Garrett Johnson, Sarah Lively, David Lapointe
  • HETEROCYCLIC INHIBITORS OF ATR KINASE
    Publication number: 20200102296
    Abstract: The present disclosure relates to heterocyclic compounds and methods which may be useful as inhibitors of ATR kinase for the treatment or prevention of cancer.
    Type: Application
    Filed: July 10, 2019
    Publication date: April 2, 2020
    Inventors: Maria Emilia DI FRANCESCO, Philip JONES, Christopher Lawrence CARROLL, Jason Bryant CROSS, Suyambu Kesava Vijayan RAMASWAMY, Michael Garrett JOHNSON, Sarah LIVELY, David LAPOINTE
  • HETEROCYCLIC INHIBITORS OF ATR KINASE
    Publication number: 20190282584
    Abstract: The present disclosure relates to heterocyclic compounds and methods which inhibit ATR kinase to treat or prevent cancer.
    Type: Application
    Filed: March 18, 2019
    Publication date: September 19, 2019
    Inventors: Maria Emilia DI FRANCESCO, Philip JONES, Christopher Lawrence CARROLL, Suyambu Kesava Vijayan RAMASWAMY, Zhijun KANG, Michael Garrett JOHNSON, Sarah LIVELY, David LAPOINTE
  • Heterocyclic inhibitors of ATR kinase
    Patent number: 10392376
    Abstract: The present disclosure relates to heterocyclic compounds and methods which may be useful as inhibitors of ATR kinase for the treatment or prevention of cancer.
    Type: Grant
    Filed: July 13, 2018
    Date of Patent: August 27, 2019
    Assignees: Board of Regents, The University of Texas System, ChemPartner Corporation
    Inventors: Maria Emilia Di Francesco, Philip Jones, Christopher Lawrence Carroll, Jason Bryant Cross, Suyambu Kesava Vijayan Ramaswamy, Michael Garrett Johnson, Sarah Lively, David Lapointe
  • HETEROCYCLIC INHIBITORS OF ATR KINASE
    Publication number: 20190016713
    Abstract: The present disclosure relates to heterocyclic compounds and methods which may be useful as inhibitors of ATR kinase for the treatment or prevention of cancer.
    Type: Application
    Filed: July 13, 2018
    Publication date: January 17, 2019
    Inventors: Maria Emilia DI FRANCESCO, Philip JONES, Christopher Lawrence CARROLL, Jason Bryant CROSS, Suyambu Kesava Vijayan RAMASWAMY, Michael Garrett JOHNSON, Sarah LIVELY, David LAPOINTE
  • METHODS FOR THE DESIGN OF MECHANISM-BASED SIRTUIN ACTIVATING COMPOUNDS
    Publication number: 20180258464
    Abstract: The instant invention provides workflows for the design and characterization of mechanism-based sirtuin modulating compounds, including new or improved sirtuin activating compounds. Workflows for the design of mechanism-based sirtuin activating compounds are provided, based on conditions that must be satisfied by activators if they are to exploit the common catalytic mechanism of all sirtuin enzymes and hence increase catalytic efficiency for any sirtuin and any substrate.
    Type: Application
    Filed: September 14, 2016
    Publication date: September 13, 2018
    Inventors: Raj CHAKRABARTI, Alok UPADHYAY, Sudipto MUNSHI, Suyambu Kesava Vijayan RAMASWAMY, Xiangying GUAN