Abstract: One aspect of the present invention provides a compound in which a functional group capable of binding to a globulin Fc region or a physiologically active polypeptide is introduced at one end of a non-peptidic polymer and a functional group capable of a click reaction is introduced at the other end; a polypeptide conjugate in which a physiologically active polypeptide binds to one end of the compound; a physiologically active polypeptide conjugate in which a physiologically active polypeptide and an immunoglobulin Fc region bind to both ends thereof by using the compound as a linker; and methods for preparing the same compound, polypeptide conjugate, and physiologically active polypeptide conjugate.

Abstract: A method for identifying mild cognitive impairment by at least one processor of an apparatus according to some embodiments of the present disclosure is disclosed. the method comprises performing a task of acquiring digital biomarker data for identifying mild cognitive impairment of a user of a user terminal; performing a preliminary task to allow the user to check the task before performing the task; and acquiring gaze information of the user in conjunction with performing the task and the preliminary task; wherein the gaze information is used when determining displayed information in the preliminary task, and used when identifying mild cognitive impairment of the user in the task.

Abstract: A use of a fusion protein of a therapeutic enzyme and an immunoglobulin Fe region is disclosed. The fusion protein is represented by the following chemical formula 1. The fusion protein shows protective effects on peripheral sensory nerves and exhibits an extended duration in the body. Thus, the fusion protein or a composition containing the fusion protein can be used in the prevention or improvement of neuropathy.

Abstract: Disclosed is a method of identifying, by at least one processor of a device, a cognitive function state of a user. The method may include inputting user information, at least one voice data, and speech time information related to the at least one voice data to a cognitive function state identification model, and identifying a cognitive function state of the user based on first output data that is output by the cognitive function state identification model.

Abstract: Disclosed is a method of identifying, by at least one processor of a device, a cognitive function state of a user. The method may include inputting user information, at least one voice data, and speech time information related to the at least one voice data to a cognitive function state identification model, and identifying a cognitive function state of the user based on first output data that is output by the cognitive function state identification model.

Abstract: Disclosed is a method of identifying dementia by at least one processor of a device. The method may include obtaining content analysis information and voice activity analysis information by using a plurality of first voice data and second voice data which have been obtained by performing a plurality of tasks in a user terminal, and identifying dementia by inputting the content analysis information and the voice activity analysis information to a dementia identification model.

Abstract: One aspect of the present invention provides a compound in which a functional group capable of binding to a globulin Fc region or a physiologically active polypeptide is introduced at one end of a non-peptidic polymer and a functional group capable of a click reaction is introduced at the other end; a polypeptide conjugate in which a physiologically active polypeptide binds to one end of the compound; a physiologically active polypeptide conjugate in which a physiologically active polypeptide and an immunoglobulin Fc region bind to both ends thereof by using the compound as a linker; and methods for preparing the same compound, polypeptide conjugate, and physiologically active polypeptide conjugate.

Abstract: Provided are a protein conjugate in which a physiologically active polypeptide is linked to a biocompatible material via a non-peptidyl polymer-coupled fatty acid derivative compound serving as a linker, exhibiting an increased duration of physiological activity compared to natural forms and a preparation method therefor. Since an increase in serum half-life of the physiologically active polypeptide of the protein conjugate, in which the biocompatible material, the non-peptidyl polymer-coupled fatty acid derivative compound, and the physiologically active polypeptide are linked, is proved, the protein conjugate may be widely used in the field of protein drugs.

Abstract: The present disclosure relates to a hydrogenated petroleum resin and a rubber composition including the same. The hydrogenated petroleum resin according to the present disclosure not only improves the viscoelastic properties of rubber containing the same, but also has excellent compatibility with rubber, thereby improving the overall physical properties of the rubber. Thus, rubber molded articles manufactured from the rubber composition containing the hydrogenated petroleum resin, for example, tires, have improved grip strength (wet/dry) and reduce an increase in rolling resistance due to the improvement in grip force to simultaneously satisfy two properties of grip force and rolling resistance required as a tire, thereby manufacturing a low-fuel consumption and high-performance tire.

Abstract: Provided are a protein conjugate in which a physiologically active polypeptide is linked to a biocompatible material via a non-peptidyl polymer-coupled fatty acid derivative compound serving as a linker, exhibiting an increased duration of physiological activity compared to natural forms and a preparation method therefor. Since an increase in serum half-life of the physiologically active polypeptide of the protein conjugate, in which the biocompatible material, the non-peptidyl polymer-coupled fatty acid derivative compound, and the physiologically active polypeptide are linked, is proved, the protein conjugate may be widely used in the field of protein drugs.

Abstract: Provided are a protein conjugate in which a physiologically active polypeptide is linked to a biocompatible material via a non-peptidyl polymer-coupled fatty acid derivative compound serving as a linker, exhibiting an increased duration of physiological activity compared to natural forms and a preparation method therefor. Since an increase in serum half-life of the physiologically active polypeptide of the protein conjugate, in which the biocompatible material, the non-peptidyl polymer-coupled fatty acid derivative compound, and the physiologically active polypeptide are linked, is proved, the protein conjugate may be widely used in the field of protein drugs.

Abstract: A method includes extracting a difference value through extraction of features of a front audio channel signal and a surround channel of multichannel sound content by setting the front audio channel signal and the surround channel as input and output channel signals, respectively, training a deep neural network (DNN) model by setting the input channel signal and the difference value as an input and an output of the DNN model, respectively, normalizing a frequency-domain signal of the input channel signal by converting the input channel signal into the frequency-domain signal, and extracting estimated difference values by decoding the normalized frequency-domain signal through the DNN model, deriving an estimated spectral amplitude of the surround channel based on the front audio channel signal and the difference value, and deriving an audio signal of a final surround channel by converting the estimated spectral amplitude of the surround channel into the time domain.

Abstract: A method includes extracting a difference value through extraction of features of a front audio channel signal and a surround channel of multichannel sound content by setting the front audio channel signal and the surround channel as input and output channel signals, respectively, training a deep neural network (DNN) model by setting the input channel signal and the difference value as an input and an output of the DNN model, respectively, normalizing a frequency-domain signal of the input channel signal by converting the input channel signal into the frequency-domain signal, and extracting estimated difference values by decoding the normalized frequency-domain signal through the DNN model, deriving an estimated spectral amplitude of the surround channel based on the front audio channel signal and the difference value, and deriving an audio signal of a final surround channel by converting the estimated spectral amplitude of the surround channel into the time domain.

Abstract: A gate all around (GAA) type semiconductor device is provided. The GAA type semiconductor device includes source/drain layers formed to be spaced apart from each other, a channel layer connecting the source/drain layers, and a gate electrode formed along the periphery of at least a portion of the channel layer, wherein lower portions of the source/drain layers are formed more deeply than the channel layer, and an insulation pattern is formed between the lower portions of the source/drain layers and lower portions of the gate electrode.