Abstract: Hydantoin based compounds useful as inhibitors of matrix metalloproteinases (MMPs), particularly macrophage elastase (MMP-12) are described. Also described are related compositions and methods of using the compounds to inhibit MMP-12 and treat diseases mediated by MMP-12, such as asthma, chronic obstructive pulmonary disease (COPD), emphysema, acute lung injury, idiopathic pulmonary fibrosis (IPF), sarcoidosis, systemic sclerosis, liver fibrosis, nonalcoholic steatohepatitis (NASH), arthritis, cancer, heart disease, inflammatory bowel disease (IBD), acute kidney injury (AKI), chronic kidney disease (CKD), Alport syndrome, and nephritis.

Abstract: Hydantoin based compounds useful as inhibitors of matrix metalloproteinases (MMPs), particularly macrophage elastase (MMP-12) are described. Also described are related compositions and methods of using the compounds to inhibit MMP-12 and treat diseases mediated by MMP-12, such as asthma, chronic obstructive pulmonary disease (COPD), emphysema, acute lung injury, idiopathic pulmonary fibrosis (IPF), sarcoidosis, systemic sclerosis, liver fibrosis, nonalcoholic steatohepatitis (NASH), arthritis, cancer, heart disease, inflammatory bowel disease (IBD), acute kidney injury (AKI), chronic kidney disease (CKD), Alport syndrome, and nephritis.

Abstract: Hydantoin based compounds useful as inhibitors of matrix metalloproteinases (MMPs), particularly macrophage elastase (MMP-12) are described. Also described are related compositions and methods of using the compounds to inhibit MMP-12 and treat diseases mediated by MMP-12, such as asthma, chronic obstructive pulmonary disease (COPD), emphysema, acute lung injury, idiopathic pulmonary fibrosis (IPF), sarcoidosis, systemic sclerosis, liver fibrosis, nonalcoholic steatohepatitis (NASH), arthritis, cancer, heart disease, inflammatory bowel disease (IBD), acute kidney injury (AKI), chronic kidney disease (CKD), Alport syndrome, and nephritis.

Abstract: Hydantoin based compounds useful as inhibitors of matrix metalloproteinases (MMPs), particularly macrophage elastase (MMP-12) are described. Also described are related compositions and methods of using the compounds to inhibit MMP-12 and treat diseases mediated by MMP-12, such as asthma, chronic obstructive pulmonary disease (COPD), emphysema, acute lung injury, idiopathic pulmonary fibrosis (IPF), sarcoidosis, systemic sclerosis, liver fibrosis, nonalcoholic steatohepatitis (NASH), arthritis, cancer, heart disease, inflammatory bowel disease (IBD), acute kidney injury (AKI), chronic kidney disease (CKD), Alport syndrome, and nephritis.

Abstract: Hydantoin based compounds useful as inhibitors of matrix metalloproteinases (MMPs), particularly macrophage elastase (MMP-12) are described. Also described are related compositions and methods of using the compounds to inhibit MMP-12 and treat diseases mediated by MMP-12, such as asthma, chronic obstructive pulmonary disease (COPD), emphysema, acute lung injury, idiopathic pulmonary fibrosis (IPF), sarcoidosis, systemic sclerosis, liver fibrosis, nonalcoholic steatohepatitis (NASH), arthritis, cancer, heart disease, inflammatory bowel disease (IBD), acute kidney injury (AKI), chronic kidney disease (CKD), Alport syndrome, and nephritis.

Abstract: Three-dimensional, living, self-regenerative structures of predetermined geometry comprising solidified print material comprising a biofilm of Bacillus subtilis comprise a TasA-R protein, wherein R is a recombinant, heterologous functional group, wherein the TasA-R provides a preferably tunable physiochemical property like viscosity, reactivity, affinity as a function of the R group.

Abstract: A refrigeration unit includes a compressor, a first heat exchanger, a second heat exchanger, a water pump, and a heat exchanging arrangement. The heat exchanging arrangement includes a main casing having a receiving cavity divided into a water atomizing compartment and one water showering compartment, a water atomizing unit, a water showering head, a fill material unit provided underneath the water showering head, and a water collection basin provided underneath the water atomizing unit and the fill material unit. A predetermined amount of heated water from the first heat exchanger is guided to flow to the water showering head and the water in the water showering head is sprinkled on the fill material unit. A predetermined amount of water from the water pump guided to flow to the water atomizing unit and the water flowing to the water atomizing unit is sprayed and atomized in the water atomizing compartment.

Abstract: A heat pump dryer includes a main casing having an air inlet channel and an air outlet channel, a compressor, a first heat exchanger positioned in the air inlet channel, a second heat exchanger positioned in the air outlet channel, a fan provided in the air inlet channel, and an energy efficient heat exchanger. The energy efficient heat exchanger has a first portion partially exposed to the air inlet channel, and a second portion partially exposed to the air outlet channel. Air is arranged to enter the air inlet channel to sequentially perform heat exchange with the first portion of the energy efficient heat exchanger and the first heat exchanger. Air passing through the air inlet channel is arranged to enter the air outlet channel to sequentially perform heat exchange with the second portion of the energy efficient heat exchanger and the second heat exchanger.

Abstract: A heat pump dryer includes a main casing having an air inlet channel and an air outlet channel, a compressor, a first heat exchanger positioned in the air inlet channel, a second heat exchanger positioned in the air outlet channel, a fan provided in the air inlet channel, and an energy efficient heat exchanger. The energy efficient heat exchanger has a first portion partially exposed to the air inlet channel, and a second portion partially exposed to the air outlet channel. Air is arranged to enter the air inlet channel to sequentially perform heat exchange with the first portion of the energy efficient heat exchanger and the first heat exchanger. Air passing through the air inlet channel is arranged to enter the air outlet channel to sequentially perform heat exchange with the second portion of the energy efficient heat exchanger and the second heat exchanger.

Abstract: Hydantoin based compounds useful as inhibitors of matrix metalloproteinases (MMPs), particularly macrophage elastase (MMP-12) are described. Also described are related compositions and methods of using the compounds to inhibit MMP-12 and treat diseases mediated by MMP-12, such as asthma, chronic obstructive pulmonary disease (COPD), emphysema, acute lung injury, idiopathic pulmonary fibrosis (IPF), sarcoidosis, systemic sclerosis, liver fibrosis, nonalcoholic steatohepatitis (NASH), arthritis, cancer, heart disease, inflammatory bowel disease (IBD), acute kidney injury (AKI), chronic kidney disease (CKD), Alport syndrome, and nephritis.

Abstract: Three-dimensional, living, self-regenerative structures of predetermined geometry comprising solidified print material comprising a biofilm of Bacillus subtilis comprise a TasA-R protein, wherein R is a recombinant, heterologous functional group, wherein the TasA-R provides a preferably tunable physiochemical property like viscosity, reactivity, affinity as a function of the R group.

Abstract: A refrigeration unit includes a compressor, a first heat exchanger, a second heat exchanger, a water pump, and a heat exchanging arrangement. The heat exchanging arrangement includes a main casing having a receiving cavity divided into a water atomizing compartment and one water showering compartment, a water atomizing unit, a water showering head, a fill material unit provided underneath the water showering head, and a water collection basin provided underneath the water atomizing unit and the fill material unit. A predetermined amount of heated water from the first heat exchanger is guided to flow to the water showering head and the water in the water showering head is sprinkled on the fill material unit. A predetermined amount of water from the water pump is guided to flow to the water atomizing unit and the water flowing to the water atomizing unit is sprayed and atomized in the water atomizing compartment.

Abstract: Hydantoin based compounds useful as inhibitors of matrix metalloproteinases (MMPs), particularly macrophage elastase (MMP-12) are described. Also described are related compositions and methods of using the compounds to inhibit MMP-12 and treat diseases mediated by MMP-12, such as asthma, chronic obstructive pulmonary disease (COPD), emphysema, acute lung injury, idiopathic pulmonary fibrosis (IPF), sarcoidosis, systemic sclerosis, liver fibrosis, nonalcoholic steatohepatitis (NASH), arthritis, cancer, heart disease, inflammatory bowel disease (IBD), acute kidney injury (AKI), chronic kidney disease (CKD), Alport syndrome, and nephritis.

Abstract: A refrigeration unit includes a compressor, a first heat exchanger, a second heat exchanger, a water pump, and a heat exchanging arrangement. The heat exchanging arrangement includes a main casing having a receiving cavity divided into a water atomizing compartment and one water showering compartment, a water atomizing unit, a water showering head, a fill material unit provided underneath the water showering head, and a water collection basin provided underneath the water atomizing unit and the fill material unit. A predetermined amount of heated water from the first heat exchanger is guided to flow to the water showering head and the water in the water showering head is sprinkled on the fill material unit. A predetermined amount of water from the water pump is guided to flow to the water atomizing unit and the water flowing to the water atomizing unit is sprayed and atomized in the water atomizing compartment.

Abstract: A heat pump dryer includes a main casing having an air inlet channel and an air outlet channel, a compressor, a first heat exchanger positioned in the air inlet channel, a second heat exchanger positioned in the air outlet channel, a fan provided in the air inlet channel, and an energy efficient heat exchanger. The energy efficient heat exchanger has a first portion partially exposed to the air inlet channel, and a second portion partially exposed to the air outlet channel. Air is arranged to enter the air inlet channel to sequentially perform heat exchange with the first portion of the energy efficient heat exchanger and the first heat exchanger. Air passing through the air inlet channel is arranged to enter the air outlet channel to sequentially perform heat exchange with the second portion of the energy efficient heat exchanger and the second heat exchanger.

Abstract: Hydantoin based compounds useful as inhibitors of matrix metalloproteinases (MMPs), particularly macrophage elastase (MMP-12) are described. Also described are related compositions and methods of using the compounds to inhibit MMP-12 and treat diseases mediated by MMP-12, such as asthma, chronic obstructive pulmonary disease (COPD), emphysema, acute lung injury, idiopathic pulmonary fibrosis (IPF), sarcoidosis, systemic sclerosis, liver fibrosis, nonalcoholic steatohepatitis (NASH), arthritis, cancer, heart disease, inflammatory bowel disease (IBD), acute kidney injury (AKI), chronic kidney disease (CKD), Alport syndrome, and nephritis.

Abstract: Hydantoin based compounds useful as inhibitors of matrix metalloproteinases (MMPs), particularly macrophage elastase (MMP-12) are described. Also described are related compositions and methods of using the compounds to inhibit MMP-12 and treat diseases mediated by MMP-12, such as asthma, chronic obstructive pulmonary disease (COPD), emphysema, acute lung injury, idiopathic pulmonary fibrosis (IPF), sarcoidosis, systemic sclerosis, liver fibrosis, nonalcoholic steatohepatitis (NASH), arthritis, cancer, heart disease, inflammatory bowel disease (IBD), acute kidney injury (AKI), chronic kidney disease (CKD), Alport syndrome, and nephritis.