Patents by Inventor Suzanne L. Bruhn

Suzanne L. Bruhn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Uses for DNA structure-specific recognition protein
    Patent number: 6475791
    Abstract: Methods disclosed herein capitalize on the ability of DNA Structure Specific Recognition Proteins (SSRPs) to bind to genomic lesions formed by chemotherapeutic agents, particularly cisplatin-type agents. Methods are provided for predicting whether an agent that damages DNA will also be cytotoxic, and for predicting whether particular eukaryotic cells will be susceptible to killing by a genotoxic drug. A screening method is provided for identifying new genotoxic drugs that produce SSRP-recognized lesions in DNA. Methods also are provided for sensitizing particular eukaryotic cells to killing by chemotherapeutic agents, particularly cisplatin-type drugs.
    Type: Grant
    Filed: June 2, 1997
    Date of Patent: November 5, 2002
    Assignee: Massachusetts Institute of Technology
    Inventors: Stephen J. Lippard, John M. Essigmann, Brian A. Donahue, Jeffrey H. Toney, Suzanne L. Bruhn, Pieter M. Pil, Steven J. Brown, Patti J. Kellett
  • Uses for DNA structure-specific recognition protein
    Patent number: 5705334
    Abstract: Methods disclosed herein capitalize on the ability of DNA Structure Specific Recognition Proteins (SSRPs) to bind to genomic lesions formed by chemotherapeutic agents, particularly cisplatin-type agents. Methods are provided for predicting whether an agent that damages DNA will also be cytotoxic, and for predicting whether particular eukaryotic cells will be susceptible to killing by a genotoxic drug. A screening method is provided for identifying new genotoxic drugs that produce SSRP-recognized lesions in DNA. Methods also are provided for sensitizing particular eukaryotic cells to killing by chemotherapeutic agents, particularly cisplatin-type drugs.
    Type: Grant
    Filed: October 25, 1994
    Date of Patent: January 6, 1998
    Assignee: Massachusetts Institute of Technology
    Inventors: Stephen J. Lippard, John M. Essigmann, Brian Donahue, Jeffrey H. Toney, Suzanne L. Bruhn, Pieter M. Pil, Steven J. Brown, Patti J. Kellett
  • DNA structure specific recognition protein complexes
    Patent number: 5670621
    Abstract: DNA structure specific recognition protein of eukaryotic origin and DNA encoding such a factor, as well as probes specific for DNA structure specific recognition protein or DNA encoding it and methods of detecting DNA structure specific recognition protein in eukaryotic cells. In particular, a mammalian cellular factor that selectively recognizes and binds DNA damaged or modified by a drug (the anticancer drug, cis-diamminedichloroplatinum (II) or cisplatin) has been identified.
    Type: Grant
    Filed: June 9, 1994
    Date of Patent: September 23, 1997
    Assignee: Massachusetts Institute of Technology
    Inventors: Brian A. Donahue, Jeffrey H. Toney, John M. Essigmann, Stephen J. Lippard, Pieter M. Pil, Suzanne L. Bruhn, Steven J. Brown, Patti J. Kellett
  • Nucleic acids encoding DNA structure-specific recognition protein and uses therefor
    Patent number: 5359047
    Abstract: DNA structure specific recognition protein of eukaryotic origin and DNA encoding such a factor, as well as probes specific for DNA structure specific recognition protein or DNA encoding it and methods of detecting DNA structure specific recognition protein in eukaryotic cells. In particular, a mammalian cellular factor that selectively recognizes and binds DNA damaged or modified by a drug (the anticancer drug, cis-diamminedichloroplatinum (II) or cisplatin) has been identified.
    Type: Grant
    Filed: December 26, 1991
    Date of Patent: October 25, 1994
    Assignee: Massachusetts Institute of Technology
    Inventors: Brian A. Donahue, Jeffrey H. Toney, John M. Essigmann, Stephen J. Lippard, Pieter M. Pil, Suzanne L. Bruhn, Steven J. Brown, Patti J. Kellett