Patents by Inventor Suzanne M de la Monte

Suzanne M de la Monte has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diagnosis and Treatment of Malignant Neoplasms
    Publication number: 20110124016
    Abstract: The invention features a method of inhibiting tumor growth and/or tumor invasiveness in a mammal by administering to a mammal a compound (e.g., an antagonistic antibody) which inhibits expression or enzymatic activity of human aspartyl (asparaginyl) beta-hydroxylase (HAAH). The invention also features a method for diagnosing the growth of a malignant neoplasm (e.g., pancreatic cancer) in a mammal by contacting a tissue or bodily fluid from the mammal with an antibody which binds to a HAAH polypeptide under conditions sufficient to form an antigen-antibody complex and/or detecting the antigen-antibody complex.
    Type: Application
    Filed: November 29, 2010
    Publication date: May 26, 2011
    Inventors: Jack R. Wands, Suzanne M. de la Monte, Alan H. Deutch, Hossein A. Ghanbari
  • Frizzled proteins and detection and treatment of cancer
    Patent number: 7867705
    Abstract: The present specification provides, inter alia, methods of using Wnt and FZD proteins, genes, FZD and Wnt-specific antibodies and probes in diagnosis and treatment of cancer and for screening test compounds for an ability to treat cancer. Also disclosed are compounds useful for treating cancer such as liver cancer.
    Type: Grant
    Filed: January 5, 2005
    Date of Patent: January 11, 2011
    Assignee: Rhode Island Hospital, a Lifespan-Partner
    Inventors: Jack R. Wands, Philippe Merle, Suzanne M. De La Monte
  • DIAGNOSIS AND TREATMENT OF MALIGNANT NEOPLASMS
    Publication number: 20100172832
    Abstract: The invention features a method for diagnosing and inhibiting growth of a malignant neoplasm in a mammal by contacting a cell or a bodily fluid of the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide. Methods of immunization to generate an HAAH-specific immune response are also within the invention.
    Type: Application
    Filed: December 21, 2009
    Publication date: July 8, 2010
    Applicant: RHODE ISLAND HOSPITAL
    Inventors: JACK R. WANDS, SUZANNE M. DE LA MONTE, ALAN H. DEUTCH, HOSSEIN A. GHANBARI
  • DIAGNOSIS AND TREATMENT OF MALIGNANT NEOPLASMS
    Publication number: 20100144837
    Abstract: The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.
    Type: Application
    Filed: November 25, 2009
    Publication date: June 10, 2010
    Applicant: Rhode Island Hospital
    Inventors: Jack R. Wands, Suzanne M. de la Monte, Nedim Ince, Rolf I. Carlson
  • DIAGNOSIS AND TREATMENT OF MALIGNANT NEOPLASMS
    Publication number: 20100136581
    Abstract: The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.
    Type: Application
    Filed: November 25, 2009
    Publication date: June 3, 2010
    Applicant: Rhode Island Hospital
    Inventors: Jack R. Wands, Suzanne M. de la Monte, Nedim Ince, Rolf I. Carlson
  • Diagnosis and treatment of malignant neoplasms
    Publication number: 20100093002
    Abstract: The invention features a method of inhibiting tumor growth and/or tumor invasiveness in a mammal by administering to a mammal a compound (e.g., an antagonistic antibody) which inhibits expression or enzymatic activity of human aspartyl (asparaginyl) beta-hydroxylase (HAAH). The invention also features a method for diagnosing the growth of a malignant neoplasm (e.g., pancreatic cancer) in a mammal by contacting a tissue or bodily fluid from the mammal with an antibody which binds to a HAAH polypeptide under conditions sufficient to form an antigen-antibody complex and/or detecting the antigen-antibody complex.
    Type: Application
    Filed: October 10, 2007
    Publication date: April 15, 2010
    Inventors: Jack R. Wands, Suzanne M. de la Monte, Alan H. Deutch, Hossein A. Ghanbari
  • Frizzled Proteins and Detection and Treatment of Cancer
    Publication number: 20080194457
    Abstract: The present specification provides, inter alia, methods of using Wnt and FZD proteins, genes, FZD and Wnt-specific antibodies and probes in diagnosis and treatment of cancer and for screening test compounds for an ability to treat cancer. Also disclosed are compounds useful for treating cancer such as liver cancer.
    Type: Application
    Filed: January 5, 2005
    Publication date: August 14, 2008
    Applicant: RHODE ISLAND HOSPITAL
    Inventors: Jack R. Wands, Philippe Merle, Suzanne M. De La Monte
  • Increased and sustained in vivo gene expression using a nucleic acid, histone and amphipathic compound composition
    Patent number: 7319094
    Abstract: The invention features a non-transgenic model of Alzheimer's Disease, method for inducing prolonged in vivo gene expression in a mammal, and methods of inhibiting Alzheimer's Disease-associated neuronal cell death.
    Type: Grant
    Filed: August 2, 2004
    Date of Patent: January 15, 2008
    Assignee: Rhode Island Hospital
    Inventors: Jack R. Wands, Suzanne M. de la Monte
  • Diagnosis and treatment of malignant neoplasms
    Patent number: 7094556
    Abstract: The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: August 22, 2006
    Assignee: Rhode Island Hospital
    Inventors: Jack R. Wands, Suzanne M de la Monte, Nedim Ince, Rolf I. Carlson
  • Diagnosis and treatment of malignant neoplasms
    Patent number: 6835370
    Abstract: The invention features a method for diagnosing and inhibiting growth of a malignant neoplasm in a mammal by contacting a cell or a bodily fluid of the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide. Methods of immunization to generate an HAAH-specific immune response are also within the invention.
    Type: Grant
    Filed: May 17, 2001
    Date of Patent: December 28, 2004
    Assignee: Rhode Island Hospital
    Inventors: Jack R. Wands, Suzanne M. de la Monte, Alan H. Deutch, Hossein A. Ghanbari
  • Diagnosis and treatment of malignant neoplasms
    Patent number: 6815415
    Abstract: The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: November 9, 2004
    Assignee: Rhode Island Hospital
    Inventors: Jack R. Wands, Suzanne M. de la Monte, Nedim Ince, Rolf I. Carlson
  • Diagnosis and treatment of malignant neoplasms
    Patent number: 6812206
    Abstract: The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: November 2, 2004
    Assignee: Rhode Island Hospital
    Inventors: Jack R. Wands, Suzanne M. de la Monte, Nedim Ince, Rolf I. Carlson
  • Diagnosis and treatment of malignant neoplasms
    Patent number: 6797696
    Abstract: The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: September 28, 2004
    Assignee: Rhode Island Hospital
    Inventors: Jack R. Wands, Suzanne M. de la Monte, Nedim Ince, Rolf I. Carlson
  • Diagnosis and treatment of malignant neoplasms
    Patent number: 6783758
    Abstract: The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: August 31, 2004
    Assignee: Rhode Island Hospital
    Inventors: Jack R. Wands, Suzanne M. de la Monte, Nedim Ince, Rolf I. Carlson
  • Non-Transgenic nonhuman model for Alzheimer's Disease using a AD7c-NTP nucleic acid
    Patent number: 6770797
    Abstract: The invention features a non-transgenic model of Alzheimer's Disease, method for inducing prolonged in vivo gene expression in a mammal, and methods of inhibiting Alzheimer's Disease-associated neuronal cell death.
    Type: Grant
    Filed: June 1, 2001
    Date of Patent: August 3, 2004
    Assignee: Rhode Island Hospital
    Inventors: Jack R. Wands, Suzanne M. de la Monte
  • Inhibition of neurodegeneration
    Publication number: 20030050262
    Abstract: The invention features a non-transgenic model of Alzheimer's Disease, method for inducing prolonged in vivo gene expression in a mammal, and methods of inhibiting Alzheimer's Disease-associated neuronal cell death.
    Type: Application
    Filed: June 1, 2001
    Publication date: March 13, 2003
    Inventors: Jack R. Wands, Suzanne M. de la Monte
  • DIAGNOSIS AND TREATMENT OF MALIGNANT NEOPLASMS
    Publication number: 20030031670
    Abstract: The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.
    Type: Application
    Filed: November 8, 1999
    Publication date: February 13, 2003
    Inventors: JACK R. WANDS, SUZANNE M. DE LA MONTE, NEDIM INCE, ROLF I. CARLSON
  • Diagnosis and treatment of malignant neoplasms
    Publication number: 20020146421
    Abstract: The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.
    Type: Application
    Filed: July 11, 2001
    Publication date: October 10, 2002
    Inventors: Jack R. Wands, Suzanne M. de la Monte, Nedim Ince, Rolf I. Carlson
  • Diagnosis and treatment of malignant neoplasms
    Publication number: 20020122802
    Abstract: The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.
    Type: Application
    Filed: July 11, 2001
    Publication date: September 5, 2002
    Inventors: Jack R. Wands, Suzanne M. de la Monte, Nedim Ince, Rolf I. Carlson
  • Diagnosis and treatment of malignant neoplasms statement as to federally sponsored research
    Publication number: 20020114810
    Abstract: The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.
    Type: Application
    Filed: July 11, 2001
    Publication date: August 22, 2002
    Inventors: Jack R. Wands, Suzanne M. de la Monte, Nedim Ince, Rolf I. Carlson