Patents by Inventor Suzanne M. Mandala

Suzanne M. Mandala has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • sphingosine 1-phosphate receptor isoform 1
    Patent number: 7611851
    Abstract: A Canis sphingosine-1-phosphate (S1P) receptor isoform 1 (cS1P1), the nucleic acid encoding the cS1P1 receptor, and methods for using the cS1P1 receptor and the nucleic acid encoding the cS1P1 receptor in assays for identifying analytes which modulate activity of the cS1P1 receptor.
    Type: Grant
    Filed: July 22, 2005
    Date of Patent: November 3, 2009
    Assignee: Merck & Co., Inc.
    Inventors: Suzanne M. Mandala, Cheryl Meyers, Gan-Ju Maria Shei
  • Canis sphingosine 1-phosphate receptor isoform 2
    Publication number: 20090202987
    Abstract: A Canis sphingosine-1-phosphate (S1P) receptor isoform 2 (cS1P2), the nucleic acid encoding the cS1P2 receptor, and methods for using the S1P2 receptor and the nucleic acid encoding the cS1P2 receptor in assays for identifying analytes that modulate activity of the cS1P2 receptor. The assays can identify analytes that are useful for treating or preventing cardiovascular diseases, disorders of the gastroenterology system, reproduction diseases, disorders of the peripheral and central nervous system, and respiratory diseases.
    Type: Application
    Filed: July 22, 2005
    Publication date: August 13, 2009
    Inventors: Suzanne M. Mandala, Cheryl Meyers, Gan-Ju Maria Shei
  • Canis sphingosine 1-phosphate receptor isoform 5
    Publication number: 20090191578
    Abstract: A Canis sphingosine-1-phosphate (S1P) receptor isoform 5 (cS1P5), the nucleic acid encoding the cS1P5 receptor, and methods for using the cS1P receptor and the nucleic acid encoding the cS1P5 receptor in assays for identifying analytes which modulate activity of the cS1P5 receptor. The assay is useful for identifying analytes for treating or preventing diseases associated with S1P5 activity.
    Type: Application
    Filed: July 22, 2005
    Publication date: July 30, 2009
    Applicant: MERCK & CO., INC
    Inventors: Suzanne M. Mandala, James A. Milligan
  • Canis sphingosine 1-phosphate receptort isoform 1
    Publication number: 20090176263
    Abstract: A Canis sphingosine-1-phosphate (S1P) receptor isoform 1 (cS1P1), the nucleic acid encoding the cS1P1 receptor, and methods for using the cS1P1 receptor and the nucleic acid encoding the cS1P1 receptor in assays for identifying analytes which modulate activity of the cS1P1 receptor.
    Type: Application
    Filed: July 22, 2005
    Publication date: July 9, 2009
    Inventors: Suzanne M. Mandala, Cheryl Meyers, Gan-Ju Maria Shei
  • Human sphingosine-1-phosphate phosphatase and inhibition methods
    Patent number: 7374889
    Abstract: The present invention provides polynucleotides and polypeptides of a human sphingosine-1-phosphate phosphatase, referred to herein as hSPP1. The polynucleotides and polypeptides are used to further provide expression vectors, host cells comprising the vectors, probes and primers, antibodies against the hSPP1 protein and polypeptides thereof, assays for the presence or expression of hSPP1 and assays for the identification of compounds that interact with hSPP1.
    Type: Grant
    Filed: February 6, 2002
    Date of Patent: May 20, 2008
    Assignee: Merck & Co., Inc.
    Inventors: Suzanne M. Mandala, Rosemary A. Thornton
  • Human sphingosine-1-phosphate phosphatase
    Publication number: 20040137447
    Abstract: The present invention provides polynucleotides and polypeptides of a human sphingosine-1-phosphate phosphatase, referred to herein as hSPP1. The polynucleotides and polypeptides are used to further provide expression vectors, host cells comprising the vectors, probes and primers, antibodies against the hSPP1 protein and polypeptides thereof, assays for the presence or expression of hSPP1 and assays for the identification of compounds that interact with hSPP1.
    Type: Application
    Filed: August 6, 2003
    Publication date: July 15, 2004
    Inventors: Suzanne M Mandala, Rosemary A Thornton
  • Selective S1P1/Edg1 receptor agonists
    Publication number: 20040058894
    Abstract: The present invention encompasses a method of treating an immunoregulatory abnormality in a mammalian patient in need of such treatment comprising administering to said patient a compound which is an agonist of the S1P1/Edg1 receptor in an amount effective for treating said immunoregulatory abnormality, wherein said compound possesses a selectivity for the S1P1/Edg1 receptor over the S1PR3/Edg3 receptor, said compound administered in an amount effective for treating said immunoregulatory abnormality. Pharmaceutical compositions and methods of use are included.
    Type: Application
    Filed: January 9, 2003
    Publication date: March 25, 2004
    Inventors: George A. Doherty, Michael J. Forrest, Richard Hajdu, Jeffrey J. Hale, Li Zhen, Suzanne M. Mandala, Sander G. Mills, Hugh Rosen
  • Polynucleotide sequences encoding mouse sphingosine-1-phosphate phosphatase
    Patent number: 6667163
    Abstract: The present invention provides polynucleotides and polypeptides of a murine sphingosine-1-phosphate phosphatase, referred to herein as mSPP1. The polynucleotides and polypeptides are used to further provide expression vectors, host cells comprising the vectors, probes and primers, antibodies against the mSPP1 protein and polypeptides thereof, assays for the presence or expression of mSPP1 and assays for the identification of compounds that interact with mSPP1.
    Type: Grant
    Filed: February 7, 2001
    Date of Patent: December 23, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Suzanne M. Mandala, Rosemary A. Thornton
  • Mammalian sphingosine - 1 - phosphate phosphatase
    Publication number: 20020012984
    Abstract: The present invention provides polynucleotides and polypeptides of a murine sphingosine-1-phosphate phosphatase, referred to herein as mSPP1. The polynucleotides and polypeptides are used to further provide expression vectors, host cells comprising the vectors, probes and primers, antibodies against the mSPP1 protein and polypeptides thereof, assays for the presence or expression of mSPP1 and assays for the identification of compounds that interact with mSPP1.
    Type: Application
    Filed: February 7, 2001
    Publication date: January 31, 2002
    Inventors: Suzanne M. Mandala, Rosemary A. Thornton
  • Anti-fungal agents
    Patent number: 5543431
    Abstract: A compound having the formula ##STR1## which is an anti-fungal agent is described. The producing organism Colletotricum accutatum is also described, along with a method of production.
    Type: Grant
    Filed: May 24, 1995
    Date of Patent: August 6, 1996
    Assignee: Merck & Co., Inc.
    Inventors: Evon A. Bolessa, Robert E. Schwartz, Gerald F. Bills, Robert A. Giacobbe, Fernando Pelaez Perez, Angeles Cabello Arroyo, Teresa Diez Matas, Isabel Martin Fernandez, Francisca Vicente Perez, Suzanne M. Mandala, Deborah L. Zink, Rosemary Thornton, John R. Thompson, James E. Curotto
  • Anti-fungal agents
    Patent number: 5461071
    Abstract: A compound having the formula ##STR1## which is an anti-fungal agent is described. The producing organism Colletotricum accutatum is also described, along with a method of production.
    Type: Grant
    Filed: October 21, 1994
    Date of Patent: October 24, 1995
    Assignee: Merck & Co., Inc.
    Inventors: Evon A. Bolessa, Robert E. Schwartz, Gerald F. Bills, Robert A. Giacobbe, Fernando Pelaez Perez, Angeles Cabello Arroyo, Teresa Diez Matas, Isabel Martin Fernandez, Francisca Vincente Perez, Suzanne M. Mandala, Deborah L. Zink, Rosemary Thornton, John R. Thompson, James E. Curotto
  • Antifungal agent
    Patent number: 5441987
    Abstract: A compound having the formula ##STR1## which is useful as an antifungal agent and for the treatment and control of several agricultural phytopathogens, including Phytophthora infestans, is disclosed.
    Type: Grant
    Filed: August 12, 1994
    Date of Patent: August 15, 1995
    Assignee: Merck & Co., Inc.
    Inventors: Guy H. Harris, James E. Curotto, Robert A. Giacobbe, Suzanne M. Mandala, Richard L. Monaghan, Richard K. Jansson, Joan A. Lasota
  • Antibiotic agents
    Patent number: 5276055
    Abstract: Compounds having the formula ##STR1## wherein R and R.sup.1 may be H or COCH.sub.3 provided that when R.sup.1 is COCH.sub.3, R is COCH.sub.3 are described.
    Type: Grant
    Filed: October 19, 1992
    Date of Patent: January 4, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Angeles Cabello, Guy Harris, Robert A. Giacobbe, Gregory L. Helms, Otto D. Hensens, Suzanne M. Mandala, E. Tracy T. Jones, Isabel Martin, Walter Rozdilsky