Patents by Inventor Suzanne M. OPALKA

Suzanne M. OPALKA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR PREPARING ALPHA-CARBOXAMIDE PYRROLIDINE DERIVATIVES
    Publication number: 20220356154
    Abstract: The disclosure relates to novel processes for preparing ?-carboxamide pyrrolidine derivatives, in particular (2S, 5R)-5-(4-((2-fluorobenzyl)oxy)phenyl)pyrrolidine-2-carboxamide, and to novel intermediates for use in said process along with processes for preparing said intermediates.
    Type: Application
    Filed: November 24, 2021
    Publication date: November 10, 2022
    Inventors: Weirong Chen, Vinny Couming, Erwin Irdam, William F. Kiesman, Daw-long A. Kwok, Tamera L. Mack, Suzanne M. Opalka, Daniel B. Patience, Donald G. Walker, Wenli Liang
  • Process for preparing alpha-carboxamide pyrrolidine derivatives
    Patent number: 11192856
    Abstract: The invention relates to a novel process for preparing a-carboxamide pyrrolidine derivatives, in particular (2S, 5R)-5-(4-((2-fluorobenzyl)oxy)phenyl)pyrrolidine-2-carboxamide, and to novel intermediates for use in said process along with processes for preparing said intermediates.
    Type: Grant
    Filed: October 5, 2018
    Date of Patent: December 7, 2021
    Assignee: Biogen Inc.
    Inventors: Weirong Chen, Vinny Couming, Erwin Irdam, William F. Kiesman, Daw-Long A. Kwok, Tamera L. Mack, Suzanne M. Opalka, Daniel B. Patience, Donald G. Walker, Wenli Liang
  • PROCESS FOR PREPARING ALPHA-CARBOXAMIDE PYRROLIDINE DERIVATIVES
    Publication number: 20200270206
    Abstract: The invention relates to a novel process for preparing a-carboxamide pyrrolidine derivatives, in particular (2S, 5R)-5-(4-((2-fluorobenzyl)oxy)phenyl)pyrrolidine-2-carboxamide, and to novel intermediates for use in said process along with processes for preparing said intermediates.
    Type: Application
    Filed: October 5, 2018
    Publication date: August 27, 2020
    Inventors: Weirong Chen, Vinny Couming, Erwin Irdam, William F. Kiesman, Daw-long A. Kwok, Tamera L. Mack, Suzanne M. Opalka, Daniel B. Patience, Donald G. Walker, Wenli Liang
  • Methods of making 2-halonicotinonitriles
    Patent number: 9951020
    Abstract: A method of making a 2-halonicotinonitrile comprises reacting an alkylidene nitrile with a C1-compound in an organic solvent and a dehydrating agent. The dehydrating agent substantially retards dimerization of the alkylidene nitrile during the reaction. The enamine intermediate that forms from the reaction is cyclized using a halide donor to make the 2-halonicotinonitrile.
    Type: Grant
    Filed: February 19, 2016
    Date of Patent: April 24, 2018
    Assignees: Virginia Commonwealth University, The Florida State University Research Foundation, Incorporated
    Inventors: D. Tyler McQuade, Frank B. Gupton, Ashley R. Longstreet, Suzanne M. Opalka
  • METHODS OF MAKING 2-HALONICOTINONITRILES
    Publication number: 20160221951
    Abstract: A method of making a 2-halonicotinonitrile comprises reacting an alkylidene nitrile with a C1-compound in an organic solvent and a dehydrating agent. The dehydrating agent substantially retards dimerization of the alkylidene nitrile during the reaction. The enamine intermediate that forms from the reaction is cyclized using a halide donor to make the 2-halonicotinonitrile.
    Type: Application
    Filed: February 19, 2016
    Publication date: August 4, 2016
    Inventors: Tyler D. MCQUADE, Frank B. GUPTON, Ashley R. LONGSTREET, Suzanne M. OPALKA