Patents by Inventor Suzanne Paradis

Suzanne Paradis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10626163
    Abstract: The present technology relates to methods of modulating the number of GABAergic synapses between at least two neurons. These methods include contacting at least one of the neurons with a PlexinB agonist or a nucleic acid molecule encoding a PlexinB agonist, such as a composition including a Sema4D polypeptide or an extracellular fragment thereof, or a nucleic acid molecule encoding the Sema4D polypeptide or extracellular fragment thereof. The present technology also relates to methods of modulating neuronal activity in the central nervous system or peripheral nervous system of a subject in need thereof by modulating the number of GABAergic synapses between at least two neurons. The present technology further relates to methods of treating a neurological disorder that would benefit from modulating neuronal activity in the central nervous system or peripheral nervous system of a subject in need thereof.
    Type: Grant
    Filed: January 24, 2014
    Date of Patent: April 21, 2020
    Assignee: Brandeis University
    Inventors: Suzanne Paradis, Anna R. Moore, Marissa S. Kuzirian
  • Patent number: 9777277
    Abstract: Disclosed are improved shRNA molecules, termed “organic shRNA” (OshRNA), that incorporate certain structural features that increase the likelihood that the desired guide strand is produced while reducing accumulation of passenger strands that might contribute to off-target effects. Also provided herein are nucleic acids encoding OshRNAs, kits, cells, and transgenic animals comprising such nucleic acids, as well as methods of making and using OshRNAs and/or nucleic acids encoding OshRNAs.
    Type: Grant
    Filed: January 29, 2014
    Date of Patent: October 3, 2017
    Assignee: Brandeis University
    Inventors: Nelson Lau, Mei Zeng, Suzanne Paradis, Marissa Kuzirian
  • Patent number: 7414169
    Abstract: Disclosed herein are novel genes and methods for the screening of therapeutics useful for treating impaired glucose tolerance conditions, as well as diagnostics and therapeutic compositions for identifying or treating such conditions.
    Type: Grant
    Filed: April 27, 2001
    Date of Patent: August 19, 2008
    Assignee: The General Hospital Corporation
    Inventors: Gary Ruvkun, Koutarou Kimura, Garth Patterson, Scott Ogg, Suzanne Paradis, Heidi Tissenbaum, Jason Morris, Allison Koweek
  • Publication number: 20020037585
    Abstract: Disclosed herein are novel genes and methods for the screening of therapeutics useful for treating impaired glucose tolerance conditions, as well as diagnostics and therapeutic compositions for identifying or treating such conditions.
    Type: Application
    Filed: April 27, 2001
    Publication date: March 28, 2002
    Inventors: Gary Ruvkun, Koutarou Kimura, Garth Patterson, Scott Ogg, Suzanne Paradis, Heidi Tissenbaum, Jason Morris, Allison Koweek
  • Patent number: 6225120
    Abstract: Disclosed herein are novel genes and methods for the screening of therapeutics useful for treating impaired glucose tolerance conditions, as well as diagnostics and therapeutic compositions for identifying or treating such conditions.
    Type: Grant
    Filed: May 15, 1997
    Date of Patent: May 1, 2001
    Assignee: The General Hospital Corporation
    Inventors: Gary Ruvkun, Koutarou Kimura, Garth Patterson, Scott Ogg, Suzanne Paradis, Heidi Tissenbaum, Jason Morris, Allison Koweek