Abstract: A method of removing senescent cells from donor tissues or cells, organs, or autologous cells or tissues forms a tissue graft. The method comprises adding at least one senolytic therapy to the tissue or cells during processing or prior to storage. The senolytic therapy preferably involves any strategy to reduce senescent cells, reduce senescence phenotype, reduce factors that can cause senescent cells, target known senescence signaling (e.g. inhibitors or RNA therapeutics). The viable tissue graft comprises live tissue with enhanced biological properties. The amount of senescent cells in the graft is reduced by at least 15% as compared to an amount of senescent cells present in normal tissue. The amount of senescence-associated secretory phenotype SASPs in the graft is reduced by at least 10% as compared to an amount of senescence-associated secretory phenotype SASPs present in normal cells.

Abstract: A flexible osteochondral tissue graft or graft containing cartilage and underlying bone is provided with slits formed by water cutting. Various slit designs, or grooves enhance the flexibility of the graft and create a controlled open-pore structure to enhance cell infiltration and/or tissue integration.

Abstract: Electronically generated information for facilitating the efficient and effective authorization of a medical procedure, treatment or medicine is provided. The information is specific to a patient's insurance company, medical need and diagnosis. An electronic database has been configured for analysis by a user such that inputs to the database result in outputs considered necessary in a preparation and submission for authorization of the medical procedure, treatment or medicine.

Abstract: Electronically generated information for facilitating the efficient and effective authorization of a medical procedure, treatment or medicine are provided. The information is specific to a patient's insurance company, medical need and diagnosis. An electronic Database has been configured for analysis by a user such that inputs to the Database result in outputs considered necessary in a preparation and submission for authorization of the medical procedure, treatment or medicine.

Abstract: Devices that can transport biological materials are described. The devices incorporate capillary channeled fibers that can effectively transport living cells as well as other biological materials such as nutrients, growth factors, waste materials, etc. The devices can include a sorptive material at one end of the fibers that can improve transport of materials through the devices. The devices can differentially transport different cell types, particularly when the fibers are held in a vertical orientation. Diagnostic devices that incorporate the capillary channeled fibers are described that can be utilized to separate cell types from one another. Tissue engineering scaffolds that incorporate the capillary channeled fibers are described that can more efficiently transport materials into and out of the scaffolds.

Abstract: Electronically generated information for facilitating the efficient and effective authorization of a medical procedure, treatment or medicine are provided. The information is specific to a patient's insurance company, medical need and diagnosis. An electronic Database has been configured for analysis by a user such that inputs to the Database result in outputs considered necessary in a preparation and submission for authorization of the medical procedure, treatment or medicine.

Abstract: Devices that can transport biological materials are described. The devices incorporate capillary channeled fibers that can effectively transport living cells as well as other biological materials such as nutrients, growth factors, waste materials, etc. The devices can include a sorptive material at one end of the fibers that can improve transport of materials through the devices. The devices can differentially transport different cell types, particularly when the fibers are held in a vertical orientation. Diagnostic devices that incorporate the capillary channeled fibers are described that can be utilized to separate cell types from one another. Tissue engineering scaffolds that incorporate the capillary channeled fibers are described that can more efficiently transport materials into and out of the scaffolds.

Abstract: Devices that can transport biological materials are described. The devices incorporate capillary channeled fibers that can effectively transport living cells as well as other biological materials such as nutrients, growth factors, waste materials, etc. The devices can include a sorptive material at one end of the fibers that can improve transport of materials through the devices. The devices can differentially transport different cell types, particularly when the fibers are held in a vertical orientation. Diagnostic devices that incorporate the capillary channeled fibers are described that can be utilized to separate cell types from one another. Tissue engineering scaffolds that incorporate the capillary channeled fibers are described that can more efficiently transport materials into and out of the scaffolds.

Abstract: Devices that can transport biological materials are described. The devices incorporate capillary channeled fibers that can effectively transport living cells as well as other biological materials such as nutrients, growth factors, waste materials, etc. The devices can include a sorptive material at one end of the fibers that can improve transport of materials through the devices. The devices can differentially transport different cell types, particularly when the fibers are held in a vertical orientation. Diagnostic devices that incorporate the capillary channeled fibers are described that can be utilized to separate cell types from one another. Tissue engineering scaffolds that incorporate the capillary channeled fibers are described that can more efficiently transport materials into and out of the scaffolds.